4,388 results found
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    The Spike D614G mutation increases SARS-CoV-2 infection of multiple human cell types

    Zharko Daniloski, Tristan X Jordan ... Neville E Sanjana
    A pervasive mutation in the Spike protein of the coronavirus that causes COVID-19 results in virions that are up to eightfold more infectious.
    1. Neuroscience

    Spike frequency adaptation supports network computations on temporally dispersed information

    Darjan Salaj, Anand Subramoney ... Wolfgang Maass
    Spike frequency adaptation provides spiking neural networks with long short-term memory.
    1. Neuroscience

    Frequency- and spike-timing-dependent mitochondrial Ca2+ signaling regulates the metabolic rate and synaptic efficacy in cortical neurons

    Ohad Stoler, Alexandra Stavsky ... Ilya Fleidervish
    Optical recordings from L5 cortical pyramidal neurons expressing mitochondria-targeted Ca2+ indicator, mitoGCaMP6m, reveal compartment-specific mitochondrial responses to spike firing and synaptic activity.
    1. Microbiology and Infectious Disease

    Lys417 acts as a molecular switch that regulates the conformation of SARS-CoV-2 spike protein

    Qibin Geng, Yushun Wan ... Fang Li
    Lys417 regulates the opening and closing of SARS-CoV-2 spike protein, allowing SARS-CoV-2 to maintain a delicate balance between infectiousness and evading host immune response.
    1. Neuroscience

    SpikeForest, reproducible web-facing ground-truth validation of automated neural spike sorters

    Jeremy Magland, James J Jun ... Alex H Barnett
    Ten popular spike sorting codes are reproducibly benchmarked for accuracy on electrophysiology datasets from eleven laboratories with interactive web-based exploration of thousands of ground-truth units.
    1. Neuroscience

    A spike sorting toolbox for up to thousands of electrodes validated with ground truth recordings in vitro and in vivo

    Pierre Yger, Giulia LB Spampinato ... Olivier Marre
    A spike sorting toolbox to quickly and reliably access the activity of thousands of neurons recorded with dense extracellular probes.
    1. Neuroscience

    A prefrontal network model operating near steady and oscillatory states links spike desynchronization and synaptic deficits in schizophrenia

    David A Crowe, Andrew Willow ... Bagrat Amirikian
    Cortical network model suggests a mechanism explaining the link between NMDAR synaptic and spike synchrony deficits observed in a pharmacological monkey model of prefrontal network failure in schizophrenia.
    1. Neuroscience

    SpikeInterface, a unified framework for spike sorting

    Alessio P Buccino, Cole L Hurwitz ... Matthias H Hennig
    SpikeInterface is an open-source software framework designed to build full analysis pipelines for extracellular recordings in a seamless and reproducible way.
    1. Neuroscience

    Inference of nonlinear receptive field subunits with spike-triggered clustering

    Nishal P Shah, Nora Brackbill ... EJ Chichilnisky
    Nonlinear receptive field subunits in retinal ganglion cells are isolated and characterized by clustering spike-triggered stimuli, and validated on population responses to naturalistic and novel closed loop stimuli.
    1. Neuroscience

    Dendritic Na+ spikes enable cortical input to drive action potential output from hippocampal CA2 pyramidal neurons

    Qian Sun, Kalyan V Srinivas ... Steven A Siegelbaum
    In the hippocampus, dendritic Na + spikes are required for signals from the entorhinal cortex to drive action potentials in CA2-but not CA1 or CA3-pyramidal neurons.

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