Lys417 regulates the opening and closing of SARS-CoV-2 spike protein, allowing SARS-CoV-2 to maintain a delicate balance between infectiousness and evading host immune response.
Ten popular spike sorting codes are reproducibly benchmarked for accuracy on electrophysiology datasets from eleven laboratories with interactive web-based exploration of thousands of ground-truth units.
Cortical network model suggests a mechanism explaining the link between NMDAR synaptic and spike synchrony deficits observed in a pharmacological monkey model of prefrontal network failure in schizophrenia.
Alessio P Buccino, Cole L Hurwitz ... Matthias H Hennig
SpikeInterface is an open-source software framework designed to build full analysis pipelines for extracellular recordings in a seamless and reproducible way.
Nonlinear receptive field subunits in retinal ganglion cells are isolated and characterized by clustering spike-triggered stimuli, and validated on population responses to naturalistic and novel closed loop stimuli.
Qian Sun, Kalyan V Srinivas ... Steven A Siegelbaum
In the hippocampus, dendritic Na + spikes are required for signals from the entorhinal cortex to drive action potentials in CA2-but not CA1 or CA3-pyramidal neurons.