data_6OGE
#
_entry.id 6OGE
#
_audit_conform.dict_name mmcif_pdbx.dic
_audit_conform.dict_version 5.399
_audit_conform.dict_location http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic
#
loop_
_database_2.database_id
_database_2.database_code
_database_2.pdbx_database_accession
_database_2.pdbx_DOI
PDB 6OGE pdb_00006oge 10.2210/pdb6oge/pdb
WWPDB D_1000240595 ? ?
EMDB EMD-20055 ? ?
#
loop_
_pdbx_audit_revision_history.ordinal
_pdbx_audit_revision_history.data_content_type
_pdbx_audit_revision_history.major_revision
_pdbx_audit_revision_history.minor_revision
_pdbx_audit_revision_history.revision_date
1 'Structure model' 1 0 2019-05-15
2 'Structure model' 1 1 2019-12-18
3 'Structure model' 2 0 2020-07-29
4 'Structure model' 2 1 2024-11-20
#
loop_
_pdbx_audit_revision_details.ordinal
_pdbx_audit_revision_details.revision_ordinal
_pdbx_audit_revision_details.data_content_type
_pdbx_audit_revision_details.provider
_pdbx_audit_revision_details.type
_pdbx_audit_revision_details.description
_pdbx_audit_revision_details.details
1 1 'Structure model' repository 'Initial release' ? ?
2 3 'Structure model' repository Remediation 'Carbohydrate remediation' ?
#
loop_
_pdbx_audit_revision_group.ordinal
_pdbx_audit_revision_group.revision_ordinal
_pdbx_audit_revision_group.data_content_type
_pdbx_audit_revision_group.group
1 2 'Structure model' Other
2 3 'Structure model' 'Atomic model'
3 3 'Structure model' 'Data collection'
4 3 'Structure model' 'Derived calculations'
5 3 'Structure model' 'Structure summary'
6 4 'Structure model' 'Data collection'
7 4 'Structure model' 'Database references'
8 4 'Structure model' 'Derived calculations'
9 4 'Structure model' 'Structure summary'
#
loop_
_pdbx_audit_revision_category.ordinal
_pdbx_audit_revision_category.revision_ordinal
_pdbx_audit_revision_category.data_content_type
_pdbx_audit_revision_category.category
1 2 'Structure model' atom_sites
2 2 'Structure model' cell
3 3 'Structure model' atom_site
4 3 'Structure model' chem_comp
5 3 'Structure model' entity
6 3 'Structure model' pdbx_branch_scheme
7 3 'Structure model' pdbx_chem_comp_identifier
8 3 'Structure model' pdbx_entity_branch
9 3 'Structure model' pdbx_entity_branch_descriptor
10 3 'Structure model' pdbx_entity_branch_link
11 3 'Structure model' pdbx_entity_branch_list
12 3 'Structure model' pdbx_entity_nonpoly
13 3 'Structure model' pdbx_nonpoly_scheme
14 3 'Structure model' pdbx_struct_assembly_gen
15 3 'Structure model' struct_asym
16 3 'Structure model' struct_conn
17 3 'Structure model' struct_site
18 3 'Structure model' struct_site_gen
19 4 'Structure model' chem_comp
20 4 'Structure model' chem_comp_atom
21 4 'Structure model' chem_comp_bond
22 4 'Structure model' database_2
23 4 'Structure model' em_admin
24 4 'Structure model' pdbx_entry_details
25 4 'Structure model' pdbx_modification_feature
26 4 'Structure model' struct_conn
#
loop_
_pdbx_audit_revision_item.ordinal
_pdbx_audit_revision_item.revision_ordinal
_pdbx_audit_revision_item.data_content_type
_pdbx_audit_revision_item.item
1 2 'Structure model' '_atom_sites.fract_transf_matrix[1][1]'
2 2 'Structure model' '_atom_sites.fract_transf_matrix[2][2]'
3 2 'Structure model' '_atom_sites.fract_transf_matrix[3][3]'
4 2 'Structure model' '_cell.Z_PDB'
5 3 'Structure model' '_atom_site.B_iso_or_equiv'
6 3 'Structure model' '_atom_site.Cartn_x'
7 3 'Structure model' '_atom_site.Cartn_y'
8 3 'Structure model' '_atom_site.Cartn_z'
9 3 'Structure model' '_atom_site.auth_asym_id'
10 3 'Structure model' '_atom_site.auth_atom_id'
11 3 'Structure model' '_atom_site.auth_comp_id'
12 3 'Structure model' '_atom_site.auth_seq_id'
13 3 'Structure model' '_atom_site.label_asym_id'
14 3 'Structure model' '_atom_site.label_atom_id'
15 3 'Structure model' '_atom_site.label_comp_id'
16 3 'Structure model' '_atom_site.label_entity_id'
17 3 'Structure model' '_atom_site.type_symbol'
18 3 'Structure model' '_chem_comp.name'
19 3 'Structure model' '_chem_comp.type'
20 3 'Structure model' '_pdbx_struct_assembly_gen.asym_id_list'
21 3 'Structure model' '_struct_conn.pdbx_role'
22 3 'Structure model' '_struct_conn.ptnr1_auth_asym_id'
23 3 'Structure model' '_struct_conn.ptnr1_auth_seq_id'
24 3 'Structure model' '_struct_conn.ptnr1_label_asym_id'
25 3 'Structure model' '_struct_conn.ptnr2_auth_asym_id'
26 3 'Structure model' '_struct_conn.ptnr2_auth_seq_id'
27 3 'Structure model' '_struct_conn.ptnr2_label_asym_id'
28 4 'Structure model' '_chem_comp.pdbx_synonyms'
29 4 'Structure model' '_database_2.pdbx_DOI'
30 4 'Structure model' '_database_2.pdbx_database_accession'
31 4 'Structure model' '_em_admin.last_update'
32 4 'Structure model' '_struct_conn.pdbx_leaving_atom_flag'
#
_pdbx_database_status.status_code REL
_pdbx_database_status.status_code_sf ?
_pdbx_database_status.status_code_mr ?
_pdbx_database_status.entry_id 6OGE
_pdbx_database_status.recvd_initial_deposition_date 2019-04-02
_pdbx_database_status.SG_entry N
_pdbx_database_status.deposit_site RCSB
_pdbx_database_status.process_site RCSB
_pdbx_database_status.status_code_cs ?
_pdbx_database_status.methods_development_category ?
_pdbx_database_status.pdb_format_compatible Y
_pdbx_database_status.status_code_nmr_data ?
#
_pdbx_database_related.db_name EMDB
_pdbx_database_related.details 'Cryo-EM structure of Her2 extracellular domain-Trastuzumab Fab-Pertuzumab Fab complex'
_pdbx_database_related.db_id EMD-20055
_pdbx_database_related.content_type 'associated EM volume'
#
loop_
_audit_author.name
_audit_author.pdbx_ordinal
_audit_author.identifier_ORCID
'Hao, Y.' 1 ?
'Yu, X.' 2 ?
'Bai, Y.' 3 ?
'Huang, X.' 4 ?
#
_citation.abstract ?
_citation.abstract_id_CAS ?
_citation.book_id_ISBN ?
_citation.book_publisher ?
_citation.book_publisher_city ?
_citation.book_title ?
_citation.coordinate_linkage ?
_citation.country US
_citation.database_id_Medline ?
_citation.details ?
_citation.id primary
_citation.journal_abbrev 'Plos One'
_citation.journal_id_ASTM ?
_citation.journal_id_CSD ?
_citation.journal_id_ISSN 1932-6203
_citation.journal_full ?
_citation.journal_issue ?
_citation.journal_volume 14
_citation.language ?
_citation.page_first e0216095
_citation.page_last e0216095
_citation.title 'Cryo-EM Structure of HER2-trastuzumab-pertuzumab complex.'
_citation.year 2019
_citation.database_id_CSD ?
_citation.pdbx_database_id_DOI 10.1371/journal.pone.0216095
_citation.pdbx_database_id_PubMed 31042744
_citation.unpublished_flag ?
#
loop_
_citation_author.citation_id
_citation_author.name
_citation_author.ordinal
_citation_author.identifier_ORCID
primary 'Hao, Y.' 1 ?
primary 'Yu, X.' 2 ?
primary 'Bai, Y.' 3 ?
primary 'McBride, H.J.' 4 ?
primary 'Huang, X.' 5 0000-0001-9350-4176
#
loop_
_entity.id
_entity.type
_entity.src_method
_entity.pdbx_description
_entity.formula_weight
_entity.pdbx_number_of_molecules
_entity.pdbx_ec
_entity.pdbx_mutation
_entity.pdbx_fragment
_entity.details
1 polymer man 'Receptor tyrosine-protein kinase erbB-2' 68536.844 1 2.7.10.1 ? ? ?
2 polymer man 'Pertuzumab FAB LIGHT CHAIN' 23548.152 1 ? ? ? ?
3 polymer man 'Pertuzumab FAB HEAVY CHAIN' 23674.486 1 ? ? ? ?
4 polymer man 'Trastuzumab FAB LIGHT CHAIN' 23466.031 1 ? ? ? ?
5 polymer man 'Trastuzumab FAB HEAVY CHAIN' 23425.180 1 ? ? ? ?
6 branched man
;alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
;
748.682 1 ? ? ? ?
7 non-polymer man 2-acetamido-2-deoxy-beta-D-glucopyranose 221.208 5 ? ? ? ?
#
_entity_name_com.entity_id 1
_entity_name_com.name
;Metastatic lymph node gene 19 protein,MLN 19,Proto-oncogene Neu,Proto-oncogene c-ErbB-2,Tyrosine kinase-type cell surface receptor HER2,p185erbB2
;
#
loop_
_entity_poly.entity_id
_entity_poly.type
_entity_poly.nstd_linkage
_entity_poly.nstd_monomer
_entity_poly.pdbx_seq_one_letter_code
_entity_poly.pdbx_seq_one_letter_code_can
_entity_poly.pdbx_strand_id
_entity_poly.pdbx_target_identifier
1 'polypeptide(L)' no no
;TQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIV
RGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALT
LIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSG
ICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVC
YGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDL
SVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPED
ECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEAD
QCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPA
;
;TQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIV
RGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALT
LIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSG
ICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVC
YGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDL
SVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPED
ECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEAD
QCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPA
;
A ?
2 'polypeptide(L)' no no
;DIQMTQSPSSLSASVGDRVTITCKASQDVSIGVAWYQQKPGKAPKLLIYSASYRYTGVPSRFSGSGSGTDFTLTISSLQP
EDFATYYCQQYYIYPYTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQ
ESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
;
;DIQMTQSPSSLSASVGDRVTITCKASQDVSIGVAWYQQKPGKAPKLLIYSASYRYTGVPSRFSGSGSGTDFTLTISSLQP
EDFATYYCQQYYIYPYTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQ
ESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
;
B ?
3 'polypeptide(L)' no no
;EVQLVESGGGLVQPGGSLRLSCAASGFTFTDYTMDWVRQAPGKGLEWVADVNPNSGGSIYNQRFKGRFTLSVDRSKNTLY
LQMNSLRAEDTAVYYCARNLGPSFYFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSW
NSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC
;
;EVQLVESGGGLVQPGGSLRLSCAASGFTFTDYTMDWVRQAPGKGLEWVADVNPNSGGSIYNQRFKGRFTLSVDRSKNTLY
LQMNSLRAEDTAVYYCARNLGPSFYFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSW
NSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC
;
C ?
4 'polypeptide(L)' no no
;DIQMTQSPSSLSASVGDRVTITCRASQDVNTAVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSRSGTDFTLTISSLQP
EDFATYYCQQHYTTPPTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQ
ESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
;
;DIQMTQSPSSLSASVGDRVTITCRASQDVNTAVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSRSGTDFTLTISSLQP
EDFATYYCQQHYTTPPTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQ
ESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
;
D ?
5 'polypeptide(L)' no no
;EVQLVESGGGLVQPGGSLRLSCAASGFNIKDTYIHWVRQAPGKGLEWVARIYPTNGYTRYADSVKGRFTISADTSKNTAY
LQMNSLRAEDTAVYYCSRWGGDGFYAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS
WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEP
;
;EVQLVESGGGLVQPGGSLRLSCAASGFNIKDTYIHWVRQAPGKGLEWVARIYPTNGYTRYADSVKGRFTISADTSKNTAY
LQMNSLRAEDTAVYYCSRWGGDGFYAMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVS
WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEP
;
E ?
#
_pdbx_entity_nonpoly.entity_id 7
_pdbx_entity_nonpoly.name 2-acetamido-2-deoxy-beta-D-glucopyranose
_pdbx_entity_nonpoly.comp_id NAG
#
loop_
_entity_poly_seq.entity_id
_entity_poly_seq.num
_entity_poly_seq.mon_id
_entity_poly_seq.hetero
1 1 THR n
1 2 GLN n
1 3 VAL n
1 4 CYS n
1 5 THR n
1 6 GLY n
1 7 THR n
1 8 ASP n
1 9 MET n
1 10 LYS n
1 11 LEU n
1 12 ARG n
1 13 LEU n
1 14 PRO n
1 15 ALA n
1 16 SER n
1 17 PRO n
1 18 GLU n
1 19 THR n
1 20 HIS n
1 21 LEU n
1 22 ASP n
1 23 MET n
1 24 LEU n
1 25 ARG n
1 26 HIS n
1 27 LEU n
1 28 TYR n
1 29 GLN n
1 30 GLY n
1 31 CYS n
1 32 GLN n
1 33 VAL n
1 34 VAL n
1 35 GLN n
1 36 GLY n
1 37 ASN n
1 38 LEU n
1 39 GLU n
1 40 LEU n
1 41 THR n
1 42 TYR n
1 43 LEU n
1 44 PRO n
1 45 THR n
1 46 ASN n
1 47 ALA n
1 48 SER n
1 49 LEU n
1 50 SER n
1 51 PHE n
1 52 LEU n
1 53 GLN n
1 54 ASP n
1 55 ILE n
1 56 GLN n
1 57 GLU n
1 58 VAL n
1 59 GLN n
1 60 GLY n
1 61 TYR n
1 62 VAL n
1 63 LEU n
1 64 ILE n
1 65 ALA n
1 66 HIS n
1 67 ASN n
1 68 GLN n
1 69 VAL n
1 70 ARG n
1 71 GLN n
1 72 VAL n
1 73 PRO n
1 74 LEU n
1 75 GLN n
1 76 ARG n
1 77 LEU n
1 78 ARG n
1 79 ILE n
1 80 VAL n
1 81 ARG n
1 82 GLY n
1 83 THR n
1 84 GLN n
1 85 LEU n
1 86 PHE n
1 87 GLU n
1 88 ASP n
1 89 ASN n
1 90 TYR n
1 91 ALA n
1 92 LEU n
1 93 ALA n
1 94 VAL n
1 95 LEU n
1 96 ASP n
1 97 ASN n
1 98 GLY n
1 99 ASP n
1 100 PRO n
1 101 LEU n
1 102 ASN n
1 103 ASN n
1 104 THR n
1 105 THR n
1 106 PRO n
1 107 VAL n
1 108 THR n
1 109 GLY n
1 110 ALA n
1 111 SER n
1 112 PRO n
1 113 GLY n
1 114 GLY n
1 115 LEU n
1 116 ARG n
1 117 GLU n
1 118 LEU n
1 119 GLN n
1 120 LEU n
1 121 ARG n
1 122 SER n
1 123 LEU n
1 124 THR n
1 125 GLU n
1 126 ILE n
1 127 LEU n
1 128 LYS n
1 129 GLY n
1 130 GLY n
1 131 VAL n
1 132 LEU n
1 133 ILE n
1 134 GLN n
1 135 ARG n
1 136 ASN n
1 137 PRO n
1 138 GLN n
1 139 LEU n
1 140 CYS n
1 141 TYR n
1 142 GLN n
1 143 ASP n
1 144 THR n
1 145 ILE n
1 146 LEU n
1 147 TRP n
1 148 LYS n
1 149 ASP n
1 150 ILE n
1 151 PHE n
1 152 HIS n
1 153 LYS n
1 154 ASN n
1 155 ASN n
1 156 GLN n
1 157 LEU n
1 158 ALA n
1 159 LEU n
1 160 THR n
1 161 LEU n
1 162 ILE n
1 163 ASP n
1 164 THR n
1 165 ASN n
1 166 ARG n
1 167 SER n
1 168 ARG n
1 169 ALA n
1 170 CYS n
1 171 HIS n
1 172 PRO n
1 173 CYS n
1 174 SER n
1 175 PRO n
1 176 MET n
1 177 CYS n
1 178 LYS n
1 179 GLY n
1 180 SER n
1 181 ARG n
1 182 CYS n
1 183 TRP n
1 184 GLY n
1 185 GLU n
1 186 SER n
1 187 SER n
1 188 GLU n
1 189 ASP n
1 190 CYS n
1 191 GLN n
1 192 SER n
1 193 LEU n
1 194 THR n
1 195 ARG n
1 196 THR n
1 197 VAL n
1 198 CYS n
1 199 ALA n
1 200 GLY n
1 201 GLY n
1 202 CYS n
1 203 ALA n
1 204 ARG n
1 205 CYS n
1 206 LYS n
1 207 GLY n
1 208 PRO n
1 209 LEU n
1 210 PRO n
1 211 THR n
1 212 ASP n
1 213 CYS n
1 214 CYS n
1 215 HIS n
1 216 GLU n
1 217 GLN n
1 218 CYS n
1 219 ALA n
1 220 ALA n
1 221 GLY n
1 222 CYS n
1 223 THR n
1 224 GLY n
1 225 PRO n
1 226 LYS n
1 227 HIS n
1 228 SER n
1 229 ASP n
1 230 CYS n
1 231 LEU n
1 232 ALA n
1 233 CYS n
1 234 LEU n
1 235 HIS n
1 236 PHE n
1 237 ASN n
1 238 HIS n
1 239 SER n
1 240 GLY n
1 241 ILE n
1 242 CYS n
1 243 GLU n
1 244 LEU n
1 245 HIS n
1 246 CYS n
1 247 PRO n
1 248 ALA n
1 249 LEU n
1 250 VAL n
1 251 THR n
1 252 TYR n
1 253 ASN n
1 254 THR n
1 255 ASP n
1 256 THR n
1 257 PHE n
1 258 GLU n
1 259 SER n
1 260 MET n
1 261 PRO n
1 262 ASN n
1 263 PRO n
1 264 GLU n
1 265 GLY n
1 266 ARG n
1 267 TYR n
1 268 THR n
1 269 PHE n
1 270 GLY n
1 271 ALA n
1 272 SER n
1 273 CYS n
1 274 VAL n
1 275 THR n
1 276 ALA n
1 277 CYS n
1 278 PRO n
1 279 TYR n
1 280 ASN n
1 281 TYR n
1 282 LEU n
1 283 SER n
1 284 THR n
1 285 ASP n
1 286 VAL n
1 287 GLY n
1 288 SER n
1 289 CYS n
1 290 THR n
1 291 LEU n
1 292 VAL n
1 293 CYS n
1 294 PRO n
1 295 LEU n
1 296 HIS n
1 297 ASN n
1 298 GLN n
1 299 GLU n
1 300 VAL n
1 301 THR n
1 302 ALA n
1 303 GLU n
1 304 ASP n
1 305 GLY n
1 306 THR n
1 307 GLN n
1 308 ARG n
1 309 CYS n
1 310 GLU n
1 311 LYS n
1 312 CYS n
1 313 SER n
1 314 LYS n
1 315 PRO n
1 316 CYS n
1 317 ALA n
1 318 ARG n
1 319 VAL n
1 320 CYS n
1 321 TYR n
1 322 GLY n
1 323 LEU n
1 324 GLY n
1 325 MET n
1 326 GLU n
1 327 HIS n
1 328 LEU n
1 329 ARG n
1 330 GLU n
1 331 VAL n
1 332 ARG n
1 333 ALA n
1 334 VAL n
1 335 THR n
1 336 SER n
1 337 ALA n
1 338 ASN n
1 339 ILE n
1 340 GLN n
1 341 GLU n
1 342 PHE n
1 343 ALA n
1 344 GLY n
1 345 CYS n
1 346 LYS n
1 347 LYS n
1 348 ILE n
1 349 PHE n
1 350 GLY n
1 351 SER n
1 352 LEU n
1 353 ALA n
1 354 PHE n
1 355 LEU n
1 356 PRO n
1 357 GLU n
1 358 SER n
1 359 PHE n
1 360 ASP n
1 361 GLY n
1 362 ASP n
1 363 PRO n
1 364 ALA n
1 365 SER n
1 366 ASN n
1 367 THR n
1 368 ALA n
1 369 PRO n
1 370 LEU n
1 371 GLN n
1 372 PRO n
1 373 GLU n
1 374 GLN n
1 375 LEU n
1 376 GLN n
1 377 VAL n
1 378 PHE n
1 379 GLU n
1 380 THR n
1 381 LEU n
1 382 GLU n
1 383 GLU n
1 384 ILE n
1 385 THR n
1 386 GLY n
1 387 TYR n
1 388 LEU n
1 389 TYR n
1 390 ILE n
1 391 SER n
1 392 ALA n
1 393 TRP n
1 394 PRO n
1 395 ASP n
1 396 SER n
1 397 LEU n
1 398 PRO n
1 399 ASP n
1 400 LEU n
1 401 SER n
1 402 VAL n
1 403 PHE n
1 404 GLN n
1 405 ASN n
1 406 LEU n
1 407 GLN n
1 408 VAL n
1 409 ILE n
1 410 ARG n
1 411 GLY n
1 412 ARG n
1 413 ILE n
1 414 LEU n
1 415 HIS n
1 416 ASN n
1 417 GLY n
1 418 ALA n
1 419 TYR n
1 420 SER n
1 421 LEU n
1 422 THR n
1 423 LEU n
1 424 GLN n
1 425 GLY n
1 426 LEU n
1 427 GLY n
1 428 ILE n
1 429 SER n
1 430 TRP n
1 431 LEU n
1 432 GLY n
1 433 LEU n
1 434 ARG n
1 435 SER n
1 436 LEU n
1 437 ARG n
1 438 GLU n
1 439 LEU n
1 440 GLY n
1 441 SER n
1 442 GLY n
1 443 LEU n
1 444 ALA n
1 445 LEU n
1 446 ILE n
1 447 HIS n
1 448 HIS n
1 449 ASN n
1 450 THR n
1 451 HIS n
1 452 LEU n
1 453 CYS n
1 454 PHE n
1 455 VAL n
1 456 HIS n
1 457 THR n
1 458 VAL n
1 459 PRO n
1 460 TRP n
1 461 ASP n
1 462 GLN n
1 463 LEU n
1 464 PHE n
1 465 ARG n
1 466 ASN n
1 467 PRO n
1 468 HIS n
1 469 GLN n
1 470 ALA n
1 471 LEU n
1 472 LEU n
1 473 HIS n
1 474 THR n
1 475 ALA n
1 476 ASN n
1 477 ARG n
1 478 PRO n
1 479 GLU n
1 480 ASP n
1 481 GLU n
1 482 CYS n
1 483 VAL n
1 484 GLY n
1 485 GLU n
1 486 GLY n
1 487 LEU n
1 488 ALA n
1 489 CYS n
1 490 HIS n
1 491 GLN n
1 492 LEU n
1 493 CYS n
1 494 ALA n
1 495 ARG n
1 496 GLY n
1 497 HIS n
1 498 CYS n
1 499 TRP n
1 500 GLY n
1 501 PRO n
1 502 GLY n
1 503 PRO n
1 504 THR n
1 505 GLN n
1 506 CYS n
1 507 VAL n
1 508 ASN n
1 509 CYS n
1 510 SER n
1 511 GLN n
1 512 PHE n
1 513 LEU n
1 514 ARG n
1 515 GLY n
1 516 GLN n
1 517 GLU n
1 518 CYS n
1 519 VAL n
1 520 GLU n
1 521 GLU n
1 522 CYS n
1 523 ARG n
1 524 VAL n
1 525 LEU n
1 526 GLN n
1 527 GLY n
1 528 LEU n
1 529 PRO n
1 530 ARG n
1 531 GLU n
1 532 TYR n
1 533 VAL n
1 534 ASN n
1 535 ALA n
1 536 ARG n
1 537 HIS n
1 538 CYS n
1 539 LEU n
1 540 PRO n
1 541 CYS n
1 542 HIS n
1 543 PRO n
1 544 GLU n
1 545 CYS n
1 546 GLN n
1 547 PRO n
1 548 GLN n
1 549 ASN n
1 550 GLY n
1 551 SER n
1 552 VAL n
1 553 THR n
1 554 CYS n
1 555 PHE n
1 556 GLY n
1 557 PRO n
1 558 GLU n
1 559 ALA n
1 560 ASP n
1 561 GLN n
1 562 CYS n
1 563 VAL n
1 564 ALA n
1 565 CYS n
1 566 ALA n
1 567 HIS n
1 568 TYR n
1 569 LYS n
1 570 ASP n
1 571 PRO n
1 572 PRO n
1 573 PHE n
1 574 CYS n
1 575 VAL n
1 576 ALA n
1 577 ARG n
1 578 CYS n
1 579 PRO n
1 580 SER n
1 581 GLY n
1 582 VAL n
1 583 LYS n
1 584 PRO n
1 585 ASP n
1 586 LEU n
1 587 SER n
1 588 TYR n
1 589 MET n
1 590 PRO n
1 591 ILE n
1 592 TRP n
1 593 LYS n
1 594 PHE n
1 595 PRO n
1 596 ASP n
1 597 GLU n
1 598 GLU n
1 599 GLY n
1 600 ALA n
1 601 CYS n
1 602 GLN n
1 603 PRO n
1 604 CYS n
1 605 PRO n
1 606 ILE n
1 607 ASN n
1 608 CYS n
1 609 THR n
1 610 HIS n
1 611 SER n
1 612 CYS n
1 613 VAL n
1 614 ASP n
1 615 LEU n
1 616 ASP n
1 617 ASP n
1 618 LYS n
1 619 GLY n
1 620 CYS n
1 621 PRO n
1 622 ALA n
2 1 ASP n
2 2 ILE n
2 3 GLN n
2 4 MET n
2 5 THR n
2 6 GLN n
2 7 SER n
2 8 PRO n
2 9 SER n
2 10 SER n
2 11 LEU n
2 12 SER n
2 13 ALA n
2 14 SER n
2 15 VAL n
2 16 GLY n
2 17 ASP n
2 18 ARG n
2 19 VAL n
2 20 THR n
2 21 ILE n
2 22 THR n
2 23 CYS n
2 24 LYS n
2 25 ALA n
2 26 SER n
2 27 GLN n
2 28 ASP n
2 29 VAL n
2 30 SER n
2 31 ILE n
2 32 GLY n
2 33 VAL n
2 34 ALA n
2 35 TRP n
2 36 TYR n
2 37 GLN n
2 38 GLN n
2 39 LYS n
2 40 PRO n
2 41 GLY n
2 42 LYS n
2 43 ALA n
2 44 PRO n
2 45 LYS n
2 46 LEU n
2 47 LEU n
2 48 ILE n
2 49 TYR n
2 50 SER n
2 51 ALA n
2 52 SER n
2 53 TYR n
2 54 ARG n
2 55 TYR n
2 56 THR n
2 57 GLY n
2 58 VAL n
2 59 PRO n
2 60 SER n
2 61 ARG n
2 62 PHE n
2 63 SER n
2 64 GLY n
2 65 SER n
2 66 GLY n
2 67 SER n
2 68 GLY n
2 69 THR n
2 70 ASP n
2 71 PHE n
2 72 THR n
2 73 LEU n
2 74 THR n
2 75 ILE n
2 76 SER n
2 77 SER n
2 78 LEU n
2 79 GLN n
2 80 PRO n
2 81 GLU n
2 82 ASP n
2 83 PHE n
2 84 ALA n
2 85 THR n
2 86 TYR n
2 87 TYR n
2 88 CYS n
2 89 GLN n
2 90 GLN n
2 91 TYR n
2 92 TYR n
2 93 ILE n
2 94 TYR n
2 95 PRO n
2 96 TYR n
2 97 THR n
2 98 PHE n
2 99 GLY n
2 100 GLN n
2 101 GLY n
2 102 THR n
2 103 LYS n
2 104 VAL n
2 105 GLU n
2 106 ILE n
2 107 LYS n
2 108 ARG n
2 109 THR n
2 110 VAL n
2 111 ALA n
2 112 ALA n
2 113 PRO n
2 114 SER n
2 115 VAL n
2 116 PHE n
2 117 ILE n
2 118 PHE n
2 119 PRO n
2 120 PRO n
2 121 SER n
2 122 ASP n
2 123 GLU n
2 124 GLN n
2 125 LEU n
2 126 LYS n
2 127 SER n
2 128 GLY n
2 129 THR n
2 130 ALA n
2 131 SER n
2 132 VAL n
2 133 VAL n
2 134 CYS n
2 135 LEU n
2 136 LEU n
2 137 ASN n
2 138 ASN n
2 139 PHE n
2 140 TYR n
2 141 PRO n
2 142 ARG n
2 143 GLU n
2 144 ALA n
2 145 LYS n
2 146 VAL n
2 147 GLN n
2 148 TRP n
2 149 LYS n
2 150 VAL n
2 151 ASP n
2 152 ASN n
2 153 ALA n
2 154 LEU n
2 155 GLN n
2 156 SER n
2 157 GLY n
2 158 ASN n
2 159 SER n
2 160 GLN n
2 161 GLU n
2 162 SER n
2 163 VAL n
2 164 THR n
2 165 GLU n
2 166 GLN n
2 167 ASP n
2 168 SER n
2 169 LYS n
2 170 ASP n
2 171 SER n
2 172 THR n
2 173 TYR n
2 174 SER n
2 175 LEU n
2 176 SER n
2 177 SER n
2 178 THR n
2 179 LEU n
2 180 THR n
2 181 LEU n
2 182 SER n
2 183 LYS n
2 184 ALA n
2 185 ASP n
2 186 TYR n
2 187 GLU n
2 188 LYS n
2 189 HIS n
2 190 LYS n
2 191 VAL n
2 192 TYR n
2 193 ALA n
2 194 CYS n
2 195 GLU n
2 196 VAL n
2 197 THR n
2 198 HIS n
2 199 GLN n
2 200 GLY n
2 201 LEU n
2 202 SER n
2 203 SER n
2 204 PRO n
2 205 VAL n
2 206 THR n
2 207 LYS n
2 208 SER n
2 209 PHE n
2 210 ASN n
2 211 ARG n
2 212 GLY n
2 213 GLU n
2 214 CYS n
3 1 GLU n
3 2 VAL n
3 3 GLN n
3 4 LEU n
3 5 VAL n
3 6 GLU n
3 7 SER n
3 8 GLY n
3 9 GLY n
3 10 GLY n
3 11 LEU n
3 12 VAL n
3 13 GLN n
3 14 PRO n
3 15 GLY n
3 16 GLY n
3 17 SER n
3 18 LEU n
3 19 ARG n
3 20 LEU n
3 21 SER n
3 22 CYS n
3 23 ALA n
3 24 ALA n
3 25 SER n
3 26 GLY n
3 27 PHE n
3 28 THR n
3 29 PHE n
3 30 THR n
3 31 ASP n
3 32 TYR n
3 33 THR n
3 34 MET n
3 35 ASP n
3 36 TRP n
3 37 VAL n
3 38 ARG n
3 39 GLN n
3 40 ALA n
3 41 PRO n
3 42 GLY n
3 43 LYS n
3 44 GLY n
3 45 LEU n
3 46 GLU n
3 47 TRP n
3 48 VAL n
3 49 ALA n
3 50 ASP n
3 51 VAL n
3 52 ASN n
3 53 PRO n
3 54 ASN n
3 55 SER n
3 56 GLY n
3 57 GLY n
3 58 SER n
3 59 ILE n
3 60 TYR n
3 61 ASN n
3 62 GLN n
3 63 ARG n
3 64 PHE n
3 65 LYS n
3 66 GLY n
3 67 ARG n
3 68 PHE n
3 69 THR n
3 70 LEU n
3 71 SER n
3 72 VAL n
3 73 ASP n
3 74 ARG n
3 75 SER n
3 76 LYS n
3 77 ASN n
3 78 THR n
3 79 LEU n
3 80 TYR n
3 81 LEU n
3 82 GLN n
3 83 MET n
3 84 ASN n
3 85 SER n
3 86 LEU n
3 87 ARG n
3 88 ALA n
3 89 GLU n
3 90 ASP n
3 91 THR n
3 92 ALA n
3 93 VAL n
3 94 TYR n
3 95 TYR n
3 96 CYS n
3 97 ALA n
3 98 ARG n
3 99 ASN n
3 100 LEU n
3 101 GLY n
3 102 PRO n
3 103 SER n
3 104 PHE n
3 105 TYR n
3 106 PHE n
3 107 ASP n
3 108 TYR n
3 109 TRP n
3 110 GLY n
3 111 GLN n
3 112 GLY n
3 113 THR n
3 114 LEU n
3 115 VAL n
3 116 THR n
3 117 VAL n
3 118 SER n
3 119 SER n
3 120 ALA n
3 121 SER n
3 122 THR n
3 123 LYS n
3 124 GLY n
3 125 PRO n
3 126 SER n
3 127 VAL n
3 128 PHE n
3 129 PRO n
3 130 LEU n
3 131 ALA n
3 132 PRO n
3 133 SER n
3 134 SER n
3 135 LYS n
3 136 SER n
3 137 THR n
3 138 SER n
3 139 GLY n
3 140 GLY n
3 141 THR n
3 142 ALA n
3 143 ALA n
3 144 LEU n
3 145 GLY n
3 146 CYS n
3 147 LEU n
3 148 VAL n
3 149 LYS n
3 150 ASP n
3 151 TYR n
3 152 PHE n
3 153 PRO n
3 154 GLU n
3 155 PRO n
3 156 VAL n
3 157 THR n
3 158 VAL n
3 159 SER n
3 160 TRP n
3 161 ASN n
3 162 SER n
3 163 GLY n
3 164 ALA n
3 165 LEU n
3 166 THR n
3 167 SER n
3 168 GLY n
3 169 VAL n
3 170 HIS n
3 171 THR n
3 172 PHE n
3 173 PRO n
3 174 ALA n
3 175 VAL n
3 176 LEU n
3 177 GLN n
3 178 SER n
3 179 SER n
3 180 GLY n
3 181 LEU n
3 182 TYR n
3 183 SER n
3 184 LEU n
3 185 SER n
3 186 SER n
3 187 VAL n
3 188 VAL n
3 189 THR n
3 190 VAL n
3 191 PRO n
3 192 SER n
3 193 SER n
3 194 SER n
3 195 LEU n
3 196 GLY n
3 197 THR n
3 198 GLN n
3 199 THR n
3 200 TYR n
3 201 ILE n
3 202 CYS n
3 203 ASN n
3 204 VAL n
3 205 ASN n
3 206 HIS n
3 207 LYS n
3 208 PRO n
3 209 SER n
3 210 ASN n
3 211 THR n
3 212 LYS n
3 213 VAL n
3 214 ASP n
3 215 LYS n
3 216 LYS n
3 217 VAL n
3 218 GLU n
3 219 PRO n
3 220 LYS n
3 221 SER n
3 222 CYS n
4 1 ASP n
4 2 ILE n
4 3 GLN n
4 4 MET n
4 5 THR n
4 6 GLN n
4 7 SER n
4 8 PRO n
4 9 SER n
4 10 SER n
4 11 LEU n
4 12 SER n
4 13 ALA n
4 14 SER n
4 15 VAL n
4 16 GLY n
4 17 ASP n
4 18 ARG n
4 19 VAL n
4 20 THR n
4 21 ILE n
4 22 THR n
4 23 CYS n
4 24 ARG n
4 25 ALA n
4 26 SER n
4 27 GLN n
4 28 ASP n
4 29 VAL n
4 30 ASN n
4 31 THR n
4 32 ALA n
4 33 VAL n
4 34 ALA n
4 35 TRP n
4 36 TYR n
4 37 GLN n
4 38 GLN n
4 39 LYS n
4 40 PRO n
4 41 GLY n
4 42 LYS n
4 43 ALA n
4 44 PRO n
4 45 LYS n
4 46 LEU n
4 47 LEU n
4 48 ILE n
4 49 TYR n
4 50 SER n
4 51 ALA n
4 52 SER n
4 53 PHE n
4 54 LEU n
4 55 TYR n
4 56 SER n
4 57 GLY n
4 58 VAL n
4 59 PRO n
4 60 SER n
4 61 ARG n
4 62 PHE n
4 63 SER n
4 64 GLY n
4 65 SER n
4 66 ARG n
4 67 SER n
4 68 GLY n
4 69 THR n
4 70 ASP n
4 71 PHE n
4 72 THR n
4 73 LEU n
4 74 THR n
4 75 ILE n
4 76 SER n
4 77 SER n
4 78 LEU n
4 79 GLN n
4 80 PRO n
4 81 GLU n
4 82 ASP n
4 83 PHE n
4 84 ALA n
4 85 THR n
4 86 TYR n
4 87 TYR n
4 88 CYS n
4 89 GLN n
4 90 GLN n
4 91 HIS n
4 92 TYR n
4 93 THR n
4 94 THR n
4 95 PRO n
4 96 PRO n
4 97 THR n
4 98 PHE n
4 99 GLY n
4 100 GLN n
4 101 GLY n
4 102 THR n
4 103 LYS n
4 104 VAL n
4 105 GLU n
4 106 ILE n
4 107 LYS n
4 108 ARG n
4 109 THR n
4 110 VAL n
4 111 ALA n
4 112 ALA n
4 113 PRO n
4 114 SER n
4 115 VAL n
4 116 PHE n
4 117 ILE n
4 118 PHE n
4 119 PRO n
4 120 PRO n
4 121 SER n
4 122 ASP n
4 123 GLU n
4 124 GLN n
4 125 LEU n
4 126 LYS n
4 127 SER n
4 128 GLY n
4 129 THR n
4 130 ALA n
4 131 SER n
4 132 VAL n
4 133 VAL n
4 134 CYS n
4 135 LEU n
4 136 LEU n
4 137 ASN n
4 138 ASN n
4 139 PHE n
4 140 TYR n
4 141 PRO n
4 142 ARG n
4 143 GLU n
4 144 ALA n
4 145 LYS n
4 146 VAL n
4 147 GLN n
4 148 TRP n
4 149 LYS n
4 150 VAL n
4 151 ASP n
4 152 ASN n
4 153 ALA n
4 154 LEU n
4 155 GLN n
4 156 SER n
4 157 GLY n
4 158 ASN n
4 159 SER n
4 160 GLN n
4 161 GLU n
4 162 SER n
4 163 VAL n
4 164 THR n
4 165 GLU n
4 166 GLN n
4 167 ASP n
4 168 SER n
4 169 LYS n
4 170 ASP n
4 171 SER n
4 172 THR n
4 173 TYR n
4 174 SER n
4 175 LEU n
4 176 SER n
4 177 SER n
4 178 THR n
4 179 LEU n
4 180 THR n
4 181 LEU n
4 182 SER n
4 183 LYS n
4 184 ALA n
4 185 ASP n
4 186 TYR n
4 187 GLU n
4 188 LYS n
4 189 HIS n
4 190 LYS n
4 191 VAL n
4 192 TYR n
4 193 ALA n
4 194 CYS n
4 195 GLU n
4 196 VAL n
4 197 THR n
4 198 HIS n
4 199 GLN n
4 200 GLY n
4 201 LEU n
4 202 SER n
4 203 SER n
4 204 PRO n
4 205 VAL n
4 206 THR n
4 207 LYS n
4 208 SER n
4 209 PHE n
4 210 ASN n
4 211 ARG n
4 212 GLY n
4 213 GLU n
4 214 CYS n
5 1 GLU n
5 2 VAL n
5 3 GLN n
5 4 LEU n
5 5 VAL n
5 6 GLU n
5 7 SER n
5 8 GLY n
5 9 GLY n
5 10 GLY n
5 11 LEU n
5 12 VAL n
5 13 GLN n
5 14 PRO n
5 15 GLY n
5 16 GLY n
5 17 SER n
5 18 LEU n
5 19 ARG n
5 20 LEU n
5 21 SER n
5 22 CYS n
5 23 ALA n
5 24 ALA n
5 25 SER n
5 26 GLY n
5 27 PHE n
5 28 ASN n
5 29 ILE n
5 30 LYS n
5 31 ASP n
5 32 THR n
5 33 TYR n
5 34 ILE n
5 35 HIS n
5 36 TRP n
5 37 VAL n
5 38 ARG n
5 39 GLN n
5 40 ALA n
5 41 PRO n
5 42 GLY n
5 43 LYS n
5 44 GLY n
5 45 LEU n
5 46 GLU n
5 47 TRP n
5 48 VAL n
5 49 ALA n
5 50 ARG n
5 51 ILE n
5 52 TYR n
5 53 PRO n
5 54 THR n
5 55 ASN n
5 56 GLY n
5 57 TYR n
5 58 THR n
5 59 ARG n
5 60 TYR n
5 61 ALA n
5 62 ASP n
5 63 SER n
5 64 VAL n
5 65 LYS n
5 66 GLY n
5 67 ARG n
5 68 PHE n
5 69 THR n
5 70 ILE n
5 71 SER n
5 72 ALA n
5 73 ASP n
5 74 THR n
5 75 SER n
5 76 LYS n
5 77 ASN n
5 78 THR n
5 79 ALA n
5 80 TYR n
5 81 LEU n
5 82 GLN n
5 83 MET n
5 84 ASN n
5 85 SER n
5 86 LEU n
5 87 ARG n
5 88 ALA n
5 89 GLU n
5 90 ASP n
5 91 THR n
5 92 ALA n
5 93 VAL n
5 94 TYR n
5 95 TYR n
5 96 CYS n
5 97 SER n
5 98 ARG n
5 99 TRP n
5 100 GLY n
5 101 GLY n
5 102 ASP n
5 103 GLY n
5 104 PHE n
5 105 TYR n
5 106 ALA n
5 107 MET n
5 108 ASP n
5 109 TYR n
5 110 TRP n
5 111 GLY n
5 112 GLN n
5 113 GLY n
5 114 THR n
5 115 LEU n
5 116 VAL n
5 117 THR n
5 118 VAL n
5 119 SER n
5 120 SER n
5 121 ALA n
5 122 SER n
5 123 THR n
5 124 LYS n
5 125 GLY n
5 126 PRO n
5 127 SER n
5 128 VAL n
5 129 PHE n
5 130 PRO n
5 131 LEU n
5 132 ALA n
5 133 PRO n
5 134 SER n
5 135 SER n
5 136 LYS n
5 137 SER n
5 138 THR n
5 139 SER n
5 140 GLY n
5 141 GLY n
5 142 THR n
5 143 ALA n
5 144 ALA n
5 145 LEU n
5 146 GLY n
5 147 CYS n
5 148 LEU n
5 149 VAL n
5 150 LYS n
5 151 ASP n
5 152 TYR n
5 153 PHE n
5 154 PRO n
5 155 GLU n
5 156 PRO n
5 157 VAL n
5 158 THR n
5 159 VAL n
5 160 SER n
5 161 TRP n
5 162 ASN n
5 163 SER n
5 164 GLY n
5 165 ALA n
5 166 LEU n
5 167 THR n
5 168 SER n
5 169 GLY n
5 170 VAL n
5 171 HIS n
5 172 THR n
5 173 PHE n
5 174 PRO n
5 175 ALA n
5 176 VAL n
5 177 LEU n
5 178 GLN n
5 179 SER n
5 180 SER n
5 181 GLY n
5 182 LEU n
5 183 TYR n
5 184 SER n
5 185 LEU n
5 186 SER n
5 187 SER n
5 188 VAL n
5 189 VAL n
5 190 THR n
5 191 VAL n
5 192 PRO n
5 193 SER n
5 194 SER n
5 195 SER n
5 196 LEU n
5 197 GLY n
5 198 THR n
5 199 GLN n
5 200 THR n
5 201 TYR n
5 202 ILE n
5 203 CYS n
5 204 ASN n
5 205 VAL n
5 206 ASN n
5 207 HIS n
5 208 LYS n
5 209 PRO n
5 210 SER n
5 211 ASN n
5 212 THR n
5 213 LYS n
5 214 VAL n
5 215 ASP n
5 216 LYS n
5 217 LYS n
5 218 VAL n
5 219 GLU n
5 220 PRO n
#
loop_
_entity_src_gen.entity_id
_entity_src_gen.pdbx_src_id
_entity_src_gen.pdbx_alt_source_flag
_entity_src_gen.pdbx_seq_type
_entity_src_gen.pdbx_beg_seq_num
_entity_src_gen.pdbx_end_seq_num
_entity_src_gen.gene_src_common_name
_entity_src_gen.gene_src_genus
_entity_src_gen.pdbx_gene_src_gene
_entity_src_gen.gene_src_species
_entity_src_gen.gene_src_strain
_entity_src_gen.gene_src_tissue
_entity_src_gen.gene_src_tissue_fraction
_entity_src_gen.gene_src_details
_entity_src_gen.pdbx_gene_src_fragment
_entity_src_gen.pdbx_gene_src_scientific_name
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id
_entity_src_gen.pdbx_gene_src_variant
_entity_src_gen.pdbx_gene_src_cell_line
_entity_src_gen.pdbx_gene_src_atcc
_entity_src_gen.pdbx_gene_src_organ
_entity_src_gen.pdbx_gene_src_organelle
_entity_src_gen.pdbx_gene_src_cell
_entity_src_gen.pdbx_gene_src_cellular_location
_entity_src_gen.host_org_common_name
_entity_src_gen.pdbx_host_org_scientific_name
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id
_entity_src_gen.host_org_genus
_entity_src_gen.pdbx_host_org_gene
_entity_src_gen.pdbx_host_org_organ
_entity_src_gen.host_org_species
_entity_src_gen.pdbx_host_org_tissue
_entity_src_gen.pdbx_host_org_tissue_fraction
_entity_src_gen.pdbx_host_org_strain
_entity_src_gen.pdbx_host_org_variant
_entity_src_gen.pdbx_host_org_cell_line
_entity_src_gen.pdbx_host_org_atcc
_entity_src_gen.pdbx_host_org_culture_collection
_entity_src_gen.pdbx_host_org_cell
_entity_src_gen.pdbx_host_org_organelle
_entity_src_gen.pdbx_host_org_cellular_location
_entity_src_gen.pdbx_host_org_vector_type
_entity_src_gen.pdbx_host_org_vector
_entity_src_gen.host_org_details
_entity_src_gen.expression_system_id
_entity_src_gen.plasmid_name
_entity_src_gen.plasmid_details
_entity_src_gen.pdbx_description
1 1 sample 'Biological sequence' 1 622 Human ? 'ERBB2, HER2, MLN19, NEU, NGL' ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ?
Human 'Homo sapiens' 9606 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
2 1 sample 'Biological sequence' 1 107 Human ? ? ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ?
'Cricetulus griseus' 10029 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
2 2 sample 'Biological sequence' 108 214 Human ? IGKC ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ?
'Cricetulus griseus' 10029 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
3 1 sample 'Biological sequence' 1 108 Human ? ? ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ?
'Cricetulus griseus' 10029 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
3 2 sample 'Biological sequence' 109 222 Human ? ? ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ?
'Cricetulus griseus' 10029 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
4 1 sample 'Biological sequence' 1 107 Human ? ? ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ?
'Cricetulus griseus' 10029 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
4 2 sample 'Biological sequence' 108 214 Human ? IGKC ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ?
'Cricetulus griseus' 10029 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
5 1 sample 'Biological sequence' 1 108 Human ? ? ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ?
'Cricetulus griseus' 10029 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
5 2 sample 'Biological sequence' 109 220 Human ? IGH@ ? ? ? ? ? ? 'Homo sapiens' 9606 ? ? ? ? ? ? ? ?
'Cricetulus griseus' 10029 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?
#
_pdbx_entity_branch.entity_id 6
_pdbx_entity_branch.type oligosaccharide
#
loop_
_pdbx_entity_branch_descriptor.ordinal
_pdbx_entity_branch_descriptor.entity_id
_pdbx_entity_branch_descriptor.descriptor
_pdbx_entity_branch_descriptor.type
_pdbx_entity_branch_descriptor.program
_pdbx_entity_branch_descriptor.program_version
1 6 DManpa1-3DManpb1-4DGlcpNAcb1-4DGlcpNAcb1-
'Glycam Condensed Sequence' GMML 1.0
2 6 'WURCS=2.0/3,4,3/[a2122h-1b_1-5_2*NCC/3=O][a1122h-1b_1-5][a1122h-1a_1-5]/1-1-2-3/a4-b1_b4-c1_c3-d1' WURCS PDB2Glycan 1.1.0
3 6 '[]{[(4+1)][b-D-GlcpNAc]{[(4+1)][b-D-GlcpNAc]{[(4+1)][b-D-Manp]{[(3+1)][a-D-Manp]{}}}}}' LINUCS PDB-CARE ?
#
loop_
_pdbx_entity_branch_link.link_id
_pdbx_entity_branch_link.entity_id
_pdbx_entity_branch_link.entity_branch_list_num_1
_pdbx_entity_branch_link.comp_id_1
_pdbx_entity_branch_link.atom_id_1
_pdbx_entity_branch_link.leaving_atom_id_1
_pdbx_entity_branch_link.entity_branch_list_num_2
_pdbx_entity_branch_link.comp_id_2
_pdbx_entity_branch_link.atom_id_2
_pdbx_entity_branch_link.leaving_atom_id_2
_pdbx_entity_branch_link.value_order
_pdbx_entity_branch_link.details
1 6 2 NAG C1 O1 1 NAG O4 HO4 sing ?
2 6 3 BMA C1 O1 2 NAG O4 HO4 sing ?
3 6 4 MAN C1 O1 3 BMA O3 HO3 sing ?
#
loop_
_chem_comp.id
_chem_comp.type
_chem_comp.mon_nstd_flag
_chem_comp.name
_chem_comp.pdbx_synonyms
_chem_comp.formula
_chem_comp.formula_weight
ALA 'L-peptide linking' y ALANINE ? 'C3 H7 N O2' 89.093
ARG 'L-peptide linking' y ARGININE ? 'C6 H15 N4 O2 1' 175.209
ASN 'L-peptide linking' y ASPARAGINE ? 'C4 H8 N2 O3' 132.118
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4' 133.103
BMA 'D-saccharide, beta linking' . beta-D-mannopyranose 'beta-D-mannose; D-mannose; mannose' 'C6 H12 O6'
180.156
CYS 'L-peptide linking' y CYSTEINE ? 'C3 H7 N O2 S' 121.158
GLN 'L-peptide linking' y GLUTAMINE ? 'C5 H10 N2 O3' 146.144
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4' 147.129
GLY 'peptide linking' y GLYCINE ? 'C2 H5 N O2' 75.067
HIS 'L-peptide linking' y HISTIDINE ? 'C6 H10 N3 O2 1' 156.162
ILE 'L-peptide linking' y ISOLEUCINE ? 'C6 H13 N O2' 131.173
LEU 'L-peptide linking' y LEUCINE ? 'C6 H13 N O2' 131.173
LYS 'L-peptide linking' y LYSINE ? 'C6 H15 N2 O2 1' 147.195
MAN 'D-saccharide, alpha linking' . alpha-D-mannopyranose 'alpha-D-mannose; D-mannose; mannose' 'C6 H12 O6'
180.156
MET 'L-peptide linking' y METHIONINE ? 'C5 H11 N O2 S' 149.211
NAG 'D-saccharide, beta linking' . 2-acetamido-2-deoxy-beta-D-glucopyranose
;N-acetyl-beta-D-glucosamine; 2-acetamido-2-deoxy-beta-D-glucose; 2-acetamido-2-deoxy-D-glucose; 2-acetamido-2-deoxy-glucose; N-ACETYL-D-GLUCOSAMINE
;
'C8 H15 N O6' 221.208
PHE 'L-peptide linking' y PHENYLALANINE ? 'C9 H11 N O2' 165.189
PRO 'L-peptide linking' y PROLINE ? 'C5 H9 N O2' 115.130
SER 'L-peptide linking' y SERINE ? 'C3 H7 N O3' 105.093
THR 'L-peptide linking' y THREONINE ? 'C4 H9 N O3' 119.119
TRP 'L-peptide linking' y TRYPTOPHAN ? 'C11 H12 N2 O2' 204.225
TYR 'L-peptide linking' y TYROSINE ? 'C9 H11 N O3' 181.189
VAL 'L-peptide linking' y VALINE ? 'C5 H11 N O2' 117.146
#
loop_
_pdbx_chem_comp_identifier.comp_id
_pdbx_chem_comp_identifier.type
_pdbx_chem_comp_identifier.program
_pdbx_chem_comp_identifier.program_version
_pdbx_chem_comp_identifier.identifier
BMA 'CONDENSED IUPAC CARBOHYDRATE SYMBOL' GMML 1.0 DManpb
BMA 'COMMON NAME' GMML 1.0 b-D-mannopyranose
BMA 'IUPAC CARBOHYDRATE SYMBOL' PDB-CARE 1.0 b-D-Manp
BMA 'SNFG CARBOHYDRATE SYMBOL' GMML 1.0 Man
MAN 'CONDENSED IUPAC CARBOHYDRATE SYMBOL' GMML 1.0 DManpa
MAN 'COMMON NAME' GMML 1.0 a-D-mannopyranose
MAN 'IUPAC CARBOHYDRATE SYMBOL' PDB-CARE 1.0 a-D-Manp
MAN 'SNFG CARBOHYDRATE SYMBOL' GMML 1.0 Man
NAG 'CONDENSED IUPAC CARBOHYDRATE SYMBOL' GMML 1.0 DGlcpNAcb
NAG 'COMMON NAME' GMML 1.0 N-acetyl-b-D-glucopyranosamine
NAG 'IUPAC CARBOHYDRATE SYMBOL' PDB-CARE 1.0 b-D-GlcpNAc
NAG 'SNFG CARBOHYDRATE SYMBOL' GMML 1.0 GlcNAc
#
loop_
_pdbx_poly_seq_scheme.asym_id
_pdbx_poly_seq_scheme.entity_id
_pdbx_poly_seq_scheme.seq_id
_pdbx_poly_seq_scheme.mon_id
_pdbx_poly_seq_scheme.ndb_seq_num
_pdbx_poly_seq_scheme.pdb_seq_num
_pdbx_poly_seq_scheme.auth_seq_num
_pdbx_poly_seq_scheme.pdb_mon_id
_pdbx_poly_seq_scheme.auth_mon_id
_pdbx_poly_seq_scheme.pdb_strand_id
_pdbx_poly_seq_scheme.pdb_ins_code
_pdbx_poly_seq_scheme.hetero
A 1 1 THR 1 23 23 THR THR A . n
A 1 2 GLN 2 24 24 GLN GLN A . n
A 1 3 VAL 3 25 25 VAL VAL A . n
A 1 4 CYS 4 26 26 CYS CYS A . n
A 1 5 THR 5 27 27 THR THR A . n
A 1 6 GLY 6 28 28 GLY GLY A . n
A 1 7 THR 7 29 29 THR THR A . n
A 1 8 ASP 8 30 30 ASP ASP A . n
A 1 9 MET 9 31 31 MET MET A . n
A 1 10 LYS 10 32 32 LYS LYS A . n
A 1 11 LEU 11 33 33 LEU LEU A . n
A 1 12 ARG 12 34 34 ARG ARG A . n
A 1 13 LEU 13 35 35 LEU LEU A . n
A 1 14 PRO 14 36 36 PRO PRO A . n
A 1 15 ALA 15 37 37 ALA ALA A . n
A 1 16 SER 16 38 38 SER SER A . n
A 1 17 PRO 17 39 39 PRO PRO A . n
A 1 18 GLU 18 40 40 GLU GLU A . n
A 1 19 THR 19 41 41 THR THR A . n
A 1 20 HIS 20 42 42 HIS HIS A . n
A 1 21 LEU 21 43 43 LEU LEU A . n
A 1 22 ASP 22 44 44 ASP ASP A . n
A 1 23 MET 23 45 45 MET MET A . n
A 1 24 LEU 24 46 46 LEU LEU A . n
A 1 25 ARG 25 47 47 ARG ARG A . n
A 1 26 HIS 26 48 48 HIS HIS A . n
A 1 27 LEU 27 49 49 LEU LEU A . n
A 1 28 TYR 28 50 50 TYR TYR A . n
A 1 29 GLN 29 51 51 GLN GLN A . n
A 1 30 GLY 30 52 52 GLY GLY A . n
A 1 31 CYS 31 53 53 CYS CYS A . n
A 1 32 GLN 32 54 54 GLN GLN A . n
A 1 33 VAL 33 55 55 VAL VAL A . n
A 1 34 VAL 34 56 56 VAL VAL A . n
A 1 35 GLN 35 57 57 GLN GLN A . n
A 1 36 GLY 36 58 58 GLY GLY A . n
A 1 37 ASN 37 59 59 ASN ASN A . n
A 1 38 LEU 38 60 60 LEU LEU A . n
A 1 39 GLU 39 61 61 GLU GLU A . n
A 1 40 LEU 40 62 62 LEU LEU A . n
A 1 41 THR 41 63 63 THR THR A . n
A 1 42 TYR 42 64 64 TYR TYR A . n
A 1 43 LEU 43 65 65 LEU LEU A . n
A 1 44 PRO 44 66 66 PRO PRO A . n
A 1 45 THR 45 67 67 THR THR A . n
A 1 46 ASN 46 68 68 ASN ASN A . n
A 1 47 ALA 47 69 69 ALA ALA A . n
A 1 48 SER 48 70 70 SER SER A . n
A 1 49 LEU 49 71 71 LEU LEU A . n
A 1 50 SER 50 72 72 SER SER A . n
A 1 51 PHE 51 73 73 PHE PHE A . n
A 1 52 LEU 52 74 74 LEU LEU A . n
A 1 53 GLN 53 75 75 GLN GLN A . n
A 1 54 ASP 54 76 76 ASP ASP A . n
A 1 55 ILE 55 77 77 ILE ILE A . n
A 1 56 GLN 56 78 78 GLN GLN A . n
A 1 57 GLU 57 79 79 GLU GLU A . n
A 1 58 VAL 58 80 80 VAL VAL A . n
A 1 59 GLN 59 81 81 GLN GLN A . n
A 1 60 GLY 60 82 82 GLY GLY A . n
A 1 61 TYR 61 83 83 TYR TYR A . n
A 1 62 VAL 62 84 84 VAL VAL A . n
A 1 63 LEU 63 85 85 LEU LEU A . n
A 1 64 ILE 64 86 86 ILE ILE A . n
A 1 65 ALA 65 87 87 ALA ALA A . n
A 1 66 HIS 66 88 88 HIS HIS A . n
A 1 67 ASN 67 89 89 ASN ASN A . n
A 1 68 GLN 68 90 90 GLN GLN A . n
A 1 69 VAL 69 91 91 VAL VAL A . n
A 1 70 ARG 70 92 92 ARG ARG A . n
A 1 71 GLN 71 93 93 GLN GLN A . n
A 1 72 VAL 72 94 94 VAL VAL A . n
A 1 73 PRO 73 95 95 PRO PRO A . n
A 1 74 LEU 74 96 96 LEU LEU A . n
A 1 75 GLN 75 97 97 GLN GLN A . n
A 1 76 ARG 76 98 98 ARG ARG A . n
A 1 77 LEU 77 99 99 LEU LEU A . n
A 1 78 ARG 78 100 100 ARG ARG A . n
A 1 79 ILE 79 101 101 ILE ILE A . n
A 1 80 VAL 80 102 102 VAL VAL A . n
A 1 81 ARG 81 103 103 ARG ARG A . n
A 1 82 GLY 82 104 104 GLY GLY A . n
A 1 83 THR 83 105 105 THR THR A . n
A 1 84 GLN 84 106 106 GLN GLN A . n
A 1 85 LEU 85 107 107 LEU LEU A . n
A 1 86 PHE 86 108 108 PHE PHE A . n
A 1 87 GLU 87 109 109 GLU GLU A . n
A 1 88 ASP 88 110 110 ASP ASP A . n
A 1 89 ASN 89 111 111 ASN ASN A . n
A 1 90 TYR 90 112 112 TYR TYR A . n
A 1 91 ALA 91 113 113 ALA ALA A . n
A 1 92 LEU 92 114 114 LEU LEU A . n
A 1 93 ALA 93 115 115 ALA ALA A . n
A 1 94 VAL 94 116 116 VAL VAL A . n
A 1 95 LEU 95 117 117 LEU LEU A . n
A 1 96 ASP 96 118 118 ASP ASP A . n
A 1 97 ASN 97 119 119 ASN ASN A . n
A 1 98 GLY 98 120 120 GLY GLY A . n
A 1 99 ASP 99 121 121 ASP ASP A . n
A 1 100 PRO 100 122 122 PRO PRO A . n
A 1 101 LEU 101 123 123 LEU LEU A . n
A 1 102 ASN 102 124 124 ASN ASN A . n
A 1 103 ASN 103 125 125 ASN ASN A . n
A 1 104 THR 104 126 126 THR THR A . n
A 1 105 THR 105 127 ? ? ? A . n
A 1 106 PRO 106 128 ? ? ? A . n
A 1 107 VAL 107 129 ? ? ? A . n
A 1 108 THR 108 130 130 THR THR A . n
A 1 109 GLY 109 131 131 GLY GLY A . n
A 1 110 ALA 110 132 132 ALA ALA A . n
A 1 111 SER 111 133 133 SER SER A . n
A 1 112 PRO 112 134 134 PRO PRO A . n
A 1 113 GLY 113 135 135 GLY GLY A . n
A 1 114 GLY 114 136 136 GLY GLY A . n
A 1 115 LEU 115 137 137 LEU LEU A . n
A 1 116 ARG 116 138 138 ARG ARG A . n
A 1 117 GLU 117 139 139 GLU GLU A . n
A 1 118 LEU 118 140 140 LEU LEU A . n
A 1 119 GLN 119 141 141 GLN GLN A . n
A 1 120 LEU 120 142 142 LEU LEU A . n
A 1 121 ARG 121 143 143 ARG ARG A . n
A 1 122 SER 122 144 144 SER SER A . n
A 1 123 LEU 123 145 145 LEU LEU A . n
A 1 124 THR 124 146 146 THR THR A . n
A 1 125 GLU 125 147 147 GLU GLU A . n
A 1 126 ILE 126 148 148 ILE ILE A . n
A 1 127 LEU 127 149 149 LEU LEU A . n
A 1 128 LYS 128 150 150 LYS LYS A . n
A 1 129 GLY 129 151 151 GLY GLY A . n
A 1 130 GLY 130 152 152 GLY GLY A . n
A 1 131 VAL 131 153 153 VAL VAL A . n
A 1 132 LEU 132 154 154 LEU LEU A . n
A 1 133 ILE 133 155 155 ILE ILE A . n
A 1 134 GLN 134 156 156 GLN GLN A . n
A 1 135 ARG 135 157 157 ARG ARG A . n
A 1 136 ASN 136 158 158 ASN ASN A . n
A 1 137 PRO 137 159 159 PRO PRO A . n
A 1 138 GLN 138 160 160 GLN GLN A . n
A 1 139 LEU 139 161 161 LEU LEU A . n
A 1 140 CYS 140 162 162 CYS CYS A . n
A 1 141 TYR 141 163 163 TYR TYR A . n
A 1 142 GLN 142 164 164 GLN GLN A . n
A 1 143 ASP 143 165 165 ASP ASP A . n
A 1 144 THR 144 166 166 THR THR A . n
A 1 145 ILE 145 167 167 ILE ILE A . n
A 1 146 LEU 146 168 168 LEU LEU A . n
A 1 147 TRP 147 169 169 TRP TRP A . n
A 1 148 LYS 148 170 170 LYS LYS A . n
A 1 149 ASP 149 171 171 ASP ASP A . n
A 1 150 ILE 150 172 172 ILE ILE A . n
A 1 151 PHE 151 173 173 PHE PHE A . n
A 1 152 HIS 152 174 174 HIS HIS A . n
A 1 153 LYS 153 175 175 LYS LYS A . n
A 1 154 ASN 154 176 176 ASN ASN A . n
A 1 155 ASN 155 177 177 ASN ASN A . n
A 1 156 GLN 156 178 178 GLN GLN A . n
A 1 157 LEU 157 179 179 LEU LEU A . n
A 1 158 ALA 158 180 180 ALA ALA A . n
A 1 159 LEU 159 181 181 LEU LEU A . n
A 1 160 THR 160 182 182 THR THR A . n
A 1 161 LEU 161 183 183 LEU LEU A . n
A 1 162 ILE 162 184 184 ILE ILE A . n
A 1 163 ASP 163 185 185 ASP ASP A . n
A 1 164 THR 164 186 186 THR THR A . n
A 1 165 ASN 165 187 187 ASN ASN A . n
A 1 166 ARG 166 188 188 ARG ARG A . n
A 1 167 SER 167 189 189 SER SER A . n
A 1 168 ARG 168 190 190 ARG ARG A . n
A 1 169 ALA 169 191 191 ALA ALA A . n
A 1 170 CYS 170 192 192 CYS CYS A . n
A 1 171 HIS 171 193 193 HIS HIS A . n
A 1 172 PRO 172 194 194 PRO PRO A . n
A 1 173 CYS 173 195 195 CYS CYS A . n
A 1 174 SER 174 196 196 SER SER A . n
A 1 175 PRO 175 197 197 PRO PRO A . n
A 1 176 MET 176 198 198 MET MET A . n
A 1 177 CYS 177 199 199 CYS CYS A . n
A 1 178 LYS 178 200 200 LYS LYS A . n
A 1 179 GLY 179 201 201 GLY GLY A . n
A 1 180 SER 180 202 202 SER SER A . n
A 1 181 ARG 181 203 203 ARG ARG A . n
A 1 182 CYS 182 204 204 CYS CYS A . n
A 1 183 TRP 183 205 205 TRP TRP A . n
A 1 184 GLY 184 206 206 GLY GLY A . n
A 1 185 GLU 185 207 207 GLU GLU A . n
A 1 186 SER 186 208 208 SER SER A . n
A 1 187 SER 187 209 209 SER SER A . n
A 1 188 GLU 188 210 210 GLU GLU A . n
A 1 189 ASP 189 211 211 ASP ASP A . n
A 1 190 CYS 190 212 212 CYS CYS A . n
A 1 191 GLN 191 213 213 GLN GLN A . n
A 1 192 SER 192 214 214 SER SER A . n
A 1 193 LEU 193 215 215 LEU LEU A . n
A 1 194 THR 194 216 216 THR THR A . n
A 1 195 ARG 195 217 217 ARG ARG A . n
A 1 196 THR 196 218 218 THR THR A . n
A 1 197 VAL 197 219 219 VAL VAL A . n
A 1 198 CYS 198 220 220 CYS CYS A . n
A 1 199 ALA 199 221 221 ALA ALA A . n
A 1 200 GLY 200 222 222 GLY GLY A . n
A 1 201 GLY 201 223 223 GLY GLY A . n
A 1 202 CYS 202 224 224 CYS CYS A . n
A 1 203 ALA 203 225 225 ALA ALA A . n
A 1 204 ARG 204 226 226 ARG ARG A . n
A 1 205 CYS 205 227 227 CYS CYS A . n
A 1 206 LYS 206 228 228 LYS LYS A . n
A 1 207 GLY 207 229 229 GLY GLY A . n
A 1 208 PRO 208 230 230 PRO PRO A . n
A 1 209 LEU 209 231 231 LEU LEU A . n
A 1 210 PRO 210 232 232 PRO PRO A . n
A 1 211 THR 211 233 233 THR THR A . n
A 1 212 ASP 212 234 234 ASP ASP A . n
A 1 213 CYS 213 235 235 CYS CYS A . n
A 1 214 CYS 214 236 236 CYS CYS A . n
A 1 215 HIS 215 237 237 HIS HIS A . n
A 1 216 GLU 216 238 238 GLU GLU A . n
A 1 217 GLN 217 239 239 GLN GLN A . n
A 1 218 CYS 218 240 240 CYS CYS A . n
A 1 219 ALA 219 241 241 ALA ALA A . n
A 1 220 ALA 220 242 242 ALA ALA A . n
A 1 221 GLY 221 243 243 GLY GLY A . n
A 1 222 CYS 222 244 244 CYS CYS A . n
A 1 223 THR 223 245 245 THR THR A . n
A 1 224 GLY 224 246 246 GLY GLY A . n
A 1 225 PRO 225 247 247 PRO PRO A . n
A 1 226 LYS 226 248 248 LYS LYS A . n
A 1 227 HIS 227 249 249 HIS HIS A . n
A 1 228 SER 228 250 250 SER SER A . n
A 1 229 ASP 229 251 251 ASP ASP A . n
A 1 230 CYS 230 252 252 CYS CYS A . n
A 1 231 LEU 231 253 253 LEU LEU A . n
A 1 232 ALA 232 254 254 ALA ALA A . n
A 1 233 CYS 233 255 255 CYS CYS A . n
A 1 234 LEU 234 256 256 LEU LEU A . n
A 1 235 HIS 235 257 257 HIS HIS A . n
A 1 236 PHE 236 258 258 PHE PHE A . n
A 1 237 ASN 237 259 259 ASN ASN A . n
A 1 238 HIS 238 260 260 HIS HIS A . n
A 1 239 SER 239 261 261 SER SER A . n
A 1 240 GLY 240 262 262 GLY GLY A . n
A 1 241 ILE 241 263 263 ILE ILE A . n
A 1 242 CYS 242 264 264 CYS CYS A . n
A 1 243 GLU 243 265 265 GLU GLU A . n
A 1 244 LEU 244 266 266 LEU LEU A . n
A 1 245 HIS 245 267 267 HIS HIS A . n
A 1 246 CYS 246 268 268 CYS CYS A . n
A 1 247 PRO 247 269 269 PRO PRO A . n
A 1 248 ALA 248 270 270 ALA ALA A . n
A 1 249 LEU 249 271 271 LEU LEU A . n
A 1 250 VAL 250 272 272 VAL VAL A . n
A 1 251 THR 251 273 273 THR THR A . n
A 1 252 TYR 252 274 274 TYR TYR A . n
A 1 253 ASN 253 275 275 ASN ASN A . n
A 1 254 THR 254 276 276 THR THR A . n
A 1 255 ASP 255 277 277 ASP ASP A . n
A 1 256 THR 256 278 278 THR THR A . n
A 1 257 PHE 257 279 279 PHE PHE A . n
A 1 258 GLU 258 280 280 GLU GLU A . n
A 1 259 SER 259 281 281 SER SER A . n
A 1 260 MET 260 282 282 MET MET A . n
A 1 261 PRO 261 283 283 PRO PRO A . n
A 1 262 ASN 262 284 284 ASN ASN A . n
A 1 263 PRO 263 285 285 PRO PRO A . n
A 1 264 GLU 264 286 286 GLU GLU A . n
A 1 265 GLY 265 287 287 GLY GLY A . n
A 1 266 ARG 266 288 288 ARG ARG A . n
A 1 267 TYR 267 289 289 TYR TYR A . n
A 1 268 THR 268 290 290 THR THR A . n
A 1 269 PHE 269 291 291 PHE PHE A . n
A 1 270 GLY 270 292 292 GLY GLY A . n
A 1 271 ALA 271 293 293 ALA ALA A . n
A 1 272 SER 272 294 294 SER SER A . n
A 1 273 CYS 273 295 295 CYS CYS A . n
A 1 274 VAL 274 296 296 VAL VAL A . n
A 1 275 THR 275 297 297 THR THR A . n
A 1 276 ALA 276 298 298 ALA ALA A . n
A 1 277 CYS 277 299 299 CYS CYS A . n
A 1 278 PRO 278 300 300 PRO PRO A . n
A 1 279 TYR 279 301 301 TYR TYR A . n
A 1 280 ASN 280 302 302 ASN ASN A . n
A 1 281 TYR 281 303 303 TYR TYR A . n
A 1 282 LEU 282 304 304 LEU LEU A . n
A 1 283 SER 283 305 305 SER SER A . n
A 1 284 THR 284 306 306 THR THR A . n
A 1 285 ASP 285 307 307 ASP ASP A . n
A 1 286 VAL 286 308 308 VAL VAL A . n
A 1 287 GLY 287 309 309 GLY GLY A . n
A 1 288 SER 288 310 310 SER SER A . n
A 1 289 CYS 289 311 311 CYS CYS A . n
A 1 290 THR 290 312 312 THR THR A . n
A 1 291 LEU 291 313 313 LEU LEU A . n
A 1 292 VAL 292 314 314 VAL VAL A . n
A 1 293 CYS 293 315 315 CYS CYS A . n
A 1 294 PRO 294 316 316 PRO PRO A . n
A 1 295 LEU 295 317 317 LEU LEU A . n
A 1 296 HIS 296 318 318 HIS HIS A . n
A 1 297 ASN 297 319 319 ASN ASN A . n
A 1 298 GLN 298 320 320 GLN GLN A . n
A 1 299 GLU 299 321 321 GLU GLU A . n
A 1 300 VAL 300 322 322 VAL VAL A . n
A 1 301 THR 301 323 323 THR THR A . n
A 1 302 ALA 302 324 324 ALA ALA A . n
A 1 303 GLU 303 325 325 GLU GLU A . n
A 1 304 ASP 304 326 326 ASP ASP A . n
A 1 305 GLY 305 327 327 GLY GLY A . n
A 1 306 THR 306 328 328 THR THR A . n
A 1 307 GLN 307 329 329 GLN GLN A . n
A 1 308 ARG 308 330 330 ARG ARG A . n
A 1 309 CYS 309 331 331 CYS CYS A . n
A 1 310 GLU 310 332 332 GLU GLU A . n
A 1 311 LYS 311 333 333 LYS LYS A . n
A 1 312 CYS 312 334 334 CYS CYS A . n
A 1 313 SER 313 335 335 SER SER A . n
A 1 314 LYS 314 336 336 LYS LYS A . n
A 1 315 PRO 315 337 337 PRO PRO A . n
A 1 316 CYS 316 338 338 CYS CYS A . n
A 1 317 ALA 317 339 339 ALA ALA A . n
A 1 318 ARG 318 340 340 ARG ARG A . n
A 1 319 VAL 319 341 341 VAL VAL A . n
A 1 320 CYS 320 342 342 CYS CYS A . n
A 1 321 TYR 321 343 343 TYR TYR A . n
A 1 322 GLY 322 344 344 GLY GLY A . n
A 1 323 LEU 323 345 345 LEU LEU A . n
A 1 324 GLY 324 346 346 GLY GLY A . n
A 1 325 MET 325 347 347 MET MET A . n
A 1 326 GLU 326 348 348 GLU GLU A . n
A 1 327 HIS 327 349 349 HIS HIS A . n
A 1 328 LEU 328 350 350 LEU LEU A . n
A 1 329 ARG 329 351 351 ARG ARG A . n
A 1 330 GLU 330 352 352 GLU GLU A . n
A 1 331 VAL 331 353 353 VAL VAL A . n
A 1 332 ARG 332 354 354 ARG ARG A . n
A 1 333 ALA 333 355 355 ALA ALA A . n
A 1 334 VAL 334 356 356 VAL VAL A . n
A 1 335 THR 335 357 357 THR THR A . n
A 1 336 SER 336 358 358 SER SER A . n
A 1 337 ALA 337 359 359 ALA ALA A . n
A 1 338 ASN 338 360 360 ASN ASN A . n
A 1 339 ILE 339 361 361 ILE ILE A . n
A 1 340 GLN 340 362 362 GLN GLN A . n
A 1 341 GLU 341 363 363 GLU GLU A . n
A 1 342 PHE 342 364 364 PHE PHE A . n
A 1 343 ALA 343 365 365 ALA ALA A . n
A 1 344 GLY 344 366 366 GLY GLY A . n
A 1 345 CYS 345 367 367 CYS CYS A . n
A 1 346 LYS 346 368 368 LYS LYS A . n
A 1 347 LYS 347 369 369 LYS LYS A . n
A 1 348 ILE 348 370 370 ILE ILE A . n
A 1 349 PHE 349 371 371 PHE PHE A . n
A 1 350 GLY 350 372 372 GLY GLY A . n
A 1 351 SER 351 373 373 SER SER A . n
A 1 352 LEU 352 374 374 LEU LEU A . n
A 1 353 ALA 353 375 375 ALA ALA A . n
A 1 354 PHE 354 376 376 PHE PHE A . n
A 1 355 LEU 355 377 377 LEU LEU A . n
A 1 356 PRO 356 378 378 PRO PRO A . n
A 1 357 GLU 357 379 379 GLU GLU A . n
A 1 358 SER 358 380 380 SER SER A . n
A 1 359 PHE 359 381 381 PHE PHE A . n
A 1 360 ASP 360 382 382 ASP ASP A . n
A 1 361 GLY 361 383 383 GLY GLY A . n
A 1 362 ASP 362 384 384 ASP ASP A . n
A 1 363 PRO 363 385 385 PRO PRO A . n
A 1 364 ALA 364 386 386 ALA ALA A . n
A 1 365 SER 365 387 387 SER SER A . n
A 1 366 ASN 366 388 388 ASN ASN A . n
A 1 367 THR 367 389 389 THR THR A . n
A 1 368 ALA 368 390 390 ALA ALA A . n
A 1 369 PRO 369 391 391 PRO PRO A . n
A 1 370 LEU 370 392 392 LEU LEU A . n
A 1 371 GLN 371 393 393 GLN GLN A . n
A 1 372 PRO 372 394 394 PRO PRO A . n
A 1 373 GLU 373 395 395 GLU GLU A . n
A 1 374 GLN 374 396 396 GLN GLN A . n
A 1 375 LEU 375 397 397 LEU LEU A . n
A 1 376 GLN 376 398 398 GLN GLN A . n
A 1 377 VAL 377 399 399 VAL VAL A . n
A 1 378 PHE 378 400 400 PHE PHE A . n
A 1 379 GLU 379 401 401 GLU GLU A . n
A 1 380 THR 380 402 402 THR THR A . n
A 1 381 LEU 381 403 403 LEU LEU A . n
A 1 382 GLU 382 404 404 GLU GLU A . n
A 1 383 GLU 383 405 405 GLU GLU A . n
A 1 384 ILE 384 406 406 ILE ILE A . n
A 1 385 THR 385 407 407 THR THR A . n
A 1 386 GLY 386 408 408 GLY GLY A . n
A 1 387 TYR 387 409 409 TYR TYR A . n
A 1 388 LEU 388 410 410 LEU LEU A . n
A 1 389 TYR 389 411 411 TYR TYR A . n
A 1 390 ILE 390 412 412 ILE ILE A . n
A 1 391 SER 391 413 413 SER SER A . n
A 1 392 ALA 392 414 414 ALA ALA A . n
A 1 393 TRP 393 415 415 TRP TRP A . n
A 1 394 PRO 394 416 416 PRO PRO A . n
A 1 395 ASP 395 417 417 ASP ASP A . n
A 1 396 SER 396 418 418 SER SER A . n
A 1 397 LEU 397 419 419 LEU LEU A . n
A 1 398 PRO 398 420 420 PRO PRO A . n
A 1 399 ASP 399 421 421 ASP ASP A . n
A 1 400 LEU 400 422 422 LEU LEU A . n
A 1 401 SER 401 423 423 SER SER A . n
A 1 402 VAL 402 424 424 VAL VAL A . n
A 1 403 PHE 403 425 425 PHE PHE A . n
A 1 404 GLN 404 426 426 GLN GLN A . n
A 1 405 ASN 405 427 427 ASN ASN A . n
A 1 406 LEU 406 428 428 LEU LEU A . n
A 1 407 GLN 407 429 429 GLN GLN A . n
A 1 408 VAL 408 430 430 VAL VAL A . n
A 1 409 ILE 409 431 431 ILE ILE A . n
A 1 410 ARG 410 432 432 ARG ARG A . n
A 1 411 GLY 411 433 433 GLY GLY A . n
A 1 412 ARG 412 434 434 ARG ARG A . n
A 1 413 ILE 413 435 435 ILE ILE A . n
A 1 414 LEU 414 436 436 LEU LEU A . n
A 1 415 HIS 415 437 437 HIS HIS A . n
A 1 416 ASN 416 438 438 ASN ASN A . n
A 1 417 GLY 417 439 439 GLY GLY A . n
A 1 418 ALA 418 440 440 ALA ALA A . n
A 1 419 TYR 419 441 441 TYR TYR A . n
A 1 420 SER 420 442 442 SER SER A . n
A 1 421 LEU 421 443 443 LEU LEU A . n
A 1 422 THR 422 444 444 THR THR A . n
A 1 423 LEU 423 445 445 LEU LEU A . n
A 1 424 GLN 424 446 446 GLN GLN A . n
A 1 425 GLY 425 447 447 GLY GLY A . n
A 1 426 LEU 426 448 448 LEU LEU A . n
A 1 427 GLY 427 449 449 GLY GLY A . n
A 1 428 ILE 428 450 450 ILE ILE A . n
A 1 429 SER 429 451 451 SER SER A . n
A 1 430 TRP 430 452 452 TRP TRP A . n
A 1 431 LEU 431 453 453 LEU LEU A . n
A 1 432 GLY 432 454 454 GLY GLY A . n
A 1 433 LEU 433 455 455 LEU LEU A . n
A 1 434 ARG 434 456 456 ARG ARG A . n
A 1 435 SER 435 457 457 SER SER A . n
A 1 436 LEU 436 458 458 LEU LEU A . n
A 1 437 ARG 437 459 459 ARG ARG A . n
A 1 438 GLU 438 460 460 GLU GLU A . n
A 1 439 LEU 439 461 461 LEU LEU A . n
A 1 440 GLY 440 462 462 GLY GLY A . n
A 1 441 SER 441 463 463 SER SER A . n
A 1 442 GLY 442 464 464 GLY GLY A . n
A 1 443 LEU 443 465 465 LEU LEU A . n
A 1 444 ALA 444 466 466 ALA ALA A . n
A 1 445 LEU 445 467 467 LEU LEU A . n
A 1 446 ILE 446 468 468 ILE ILE A . n
A 1 447 HIS 447 469 469 HIS HIS A . n
A 1 448 HIS 448 470 470 HIS HIS A . n
A 1 449 ASN 449 471 471 ASN ASN A . n
A 1 450 THR 450 472 472 THR THR A . n
A 1 451 HIS 451 473 473 HIS HIS A . n
A 1 452 LEU 452 474 474 LEU LEU A . n
A 1 453 CYS 453 475 475 CYS CYS A . n
A 1 454 PHE 454 476 476 PHE PHE A . n
A 1 455 VAL 455 477 477 VAL VAL A . n
A 1 456 HIS 456 478 478 HIS HIS A . n
A 1 457 THR 457 479 479 THR THR A . n
A 1 458 VAL 458 480 480 VAL VAL A . n
A 1 459 PRO 459 481 481 PRO PRO A . n
A 1 460 TRP 460 482 482 TRP TRP A . n
A 1 461 ASP 461 483 483 ASP ASP A . n
A 1 462 GLN 462 484 484 GLN GLN A . n
A 1 463 LEU 463 485 485 LEU LEU A . n
A 1 464 PHE 464 486 486 PHE PHE A . n
A 1 465 ARG 465 487 487 ARG ARG A . n
A 1 466 ASN 466 488 488 ASN ASN A . n
A 1 467 PRO 467 489 489 PRO PRO A . n
A 1 468 HIS 468 490 490 HIS HIS A . n
A 1 469 GLN 469 491 491 GLN GLN A . n
A 1 470 ALA 470 492 492 ALA ALA A . n
A 1 471 LEU 471 493 493 LEU LEU A . n
A 1 472 LEU 472 494 494 LEU LEU A . n
A 1 473 HIS 473 495 495 HIS HIS A . n
A 1 474 THR 474 496 496 THR THR A . n
A 1 475 ALA 475 497 497 ALA ALA A . n
A 1 476 ASN 476 498 498 ASN ASN A . n
A 1 477 ARG 477 499 499 ARG ARG A . n
A 1 478 PRO 478 500 500 PRO PRO A . n
A 1 479 GLU 479 501 501 GLU GLU A . n
A 1 480 ASP 480 502 502 ASP ASP A . n
A 1 481 GLU 481 503 503 GLU GLU A . n
A 1 482 CYS 482 504 504 CYS CYS A . n
A 1 483 VAL 483 505 505 VAL VAL A . n
A 1 484 GLY 484 506 506 GLY GLY A . n
A 1 485 GLU 485 507 507 GLU GLU A . n
A 1 486 GLY 486 508 508 GLY GLY A . n
A 1 487 LEU 487 509 509 LEU LEU A . n
A 1 488 ALA 488 510 510 ALA ALA A . n
A 1 489 CYS 489 511 511 CYS CYS A . n
A 1 490 HIS 490 512 512 HIS HIS A . n
A 1 491 GLN 491 513 513 GLN GLN A . n
A 1 492 LEU 492 514 514 LEU LEU A . n
A 1 493 CYS 493 515 515 CYS CYS A . n
A 1 494 ALA 494 516 516 ALA ALA A . n
A 1 495 ARG 495 517 517 ARG ARG A . n
A 1 496 GLY 496 518 518 GLY GLY A . n
A 1 497 HIS 497 519 519 HIS HIS A . n
A 1 498 CYS 498 520 520 CYS CYS A . n
A 1 499 TRP 499 521 521 TRP TRP A . n
A 1 500 GLY 500 522 522 GLY GLY A . n
A 1 501 PRO 501 523 523 PRO PRO A . n
A 1 502 GLY 502 524 524 GLY GLY A . n
A 1 503 PRO 503 525 525 PRO PRO A . n
A 1 504 THR 504 526 526 THR THR A . n
A 1 505 GLN 505 527 527 GLN GLN A . n
A 1 506 CYS 506 528 528 CYS CYS A . n
A 1 507 VAL 507 529 529 VAL VAL A . n
A 1 508 ASN 508 530 530 ASN ASN A . n
A 1 509 CYS 509 531 531 CYS CYS A . n
A 1 510 SER 510 532 532 SER SER A . n
A 1 511 GLN 511 533 533 GLN GLN A . n
A 1 512 PHE 512 534 534 PHE PHE A . n
A 1 513 LEU 513 535 535 LEU LEU A . n
A 1 514 ARG 514 536 536 ARG ARG A . n
A 1 515 GLY 515 537 537 GLY GLY A . n
A 1 516 GLN 516 538 538 GLN GLN A . n
A 1 517 GLU 517 539 539 GLU GLU A . n
A 1 518 CYS 518 540 540 CYS CYS A . n
A 1 519 VAL 519 541 541 VAL VAL A . n
A 1 520 GLU 520 542 542 GLU GLU A . n
A 1 521 GLU 521 543 543 GLU GLU A . n
A 1 522 CYS 522 544 544 CYS CYS A . n
A 1 523 ARG 523 545 545 ARG ARG A . n
A 1 524 VAL 524 546 546 VAL VAL A . n
A 1 525 LEU 525 547 547 LEU LEU A . n
A 1 526 GLN 526 548 548 GLN GLN A . n
A 1 527 GLY 527 549 549 GLY GLY A . n
A 1 528 LEU 528 550 550 LEU LEU A . n
A 1 529 PRO 529 551 551 PRO PRO A . n
A 1 530 ARG 530 552 552 ARG ARG A . n
A 1 531 GLU 531 553 553 GLU GLU A . n
A 1 532 TYR 532 554 554 TYR TYR A . n
A 1 533 VAL 533 555 555 VAL VAL A . n
A 1 534 ASN 534 556 556 ASN ASN A . n
A 1 535 ALA 535 557 557 ALA ALA A . n
A 1 536 ARG 536 558 558 ARG ARG A . n
A 1 537 HIS 537 559 559 HIS HIS A . n
A 1 538 CYS 538 560 560 CYS CYS A . n
A 1 539 LEU 539 561 561 LEU LEU A . n
A 1 540 PRO 540 562 562 PRO PRO A . n
A 1 541 CYS 541 563 563 CYS CYS A . n
A 1 542 HIS 542 564 564 HIS HIS A . n
A 1 543 PRO 543 565 565 PRO PRO A . n
A 1 544 GLU 544 566 566 GLU GLU A . n
A 1 545 CYS 545 567 567 CYS CYS A . n
A 1 546 GLN 546 568 568 GLN GLN A . n
A 1 547 PRO 547 569 569 PRO PRO A . n
A 1 548 GLN 548 570 570 GLN GLN A . n
A 1 549 ASN 549 571 571 ASN ASN A . n
A 1 550 GLY 550 572 572 GLY GLY A . n
A 1 551 SER 551 573 573 SER SER A . n
A 1 552 VAL 552 574 574 VAL VAL A . n
A 1 553 THR 553 575 575 THR THR A . n
A 1 554 CYS 554 576 576 CYS CYS A . n
A 1 555 PHE 555 577 577 PHE PHE A . n
A 1 556 GLY 556 578 578 GLY GLY A . n
A 1 557 PRO 557 579 579 PRO PRO A . n
A 1 558 GLU 558 580 580 GLU GLU A . n
A 1 559 ALA 559 581 581 ALA ALA A . n
A 1 560 ASP 560 582 582 ASP ASP A . n
A 1 561 GLN 561 583 583 GLN GLN A . n
A 1 562 CYS 562 584 584 CYS CYS A . n
A 1 563 VAL 563 585 585 VAL VAL A . n
A 1 564 ALA 564 586 586 ALA ALA A . n
A 1 565 CYS 565 587 587 CYS CYS A . n
A 1 566 ALA 566 588 588 ALA ALA A . n
A 1 567 HIS 567 589 589 HIS HIS A . n
A 1 568 TYR 568 590 590 TYR TYR A . n
A 1 569 LYS 569 591 591 LYS LYS A . n
A 1 570 ASP 570 592 592 ASP ASP A . n
A 1 571 PRO 571 593 593 PRO PRO A . n
A 1 572 PRO 572 594 594 PRO PRO A . n
A 1 573 PHE 573 595 595 PHE PHE A . n
A 1 574 CYS 574 596 596 CYS CYS A . n
A 1 575 VAL 575 597 597 VAL VAL A . n
A 1 576 ALA 576 598 598 ALA ALA A . n
A 1 577 ARG 577 599 599 ARG ARG A . n
A 1 578 CYS 578 600 600 CYS CYS A . n
A 1 579 PRO 579 601 601 PRO PRO A . n
A 1 580 SER 580 602 602 SER SER A . n
A 1 581 GLY 581 603 603 GLY GLY A . n
A 1 582 VAL 582 604 604 VAL VAL A . n
A 1 583 LYS 583 605 605 LYS LYS A . n
A 1 584 PRO 584 606 606 PRO PRO A . n
A 1 585 ASP 585 607 607 ASP ASP A . n
A 1 586 LEU 586 608 608 LEU LEU A . n
A 1 587 SER 587 609 609 SER SER A . n
A 1 588 TYR 588 610 610 TYR TYR A . n
A 1 589 MET 589 611 611 MET MET A . n
A 1 590 PRO 590 612 612 PRO PRO A . n
A 1 591 ILE 591 613 613 ILE ILE A . n
A 1 592 TRP 592 614 614 TRP TRP A . n
A 1 593 LYS 593 615 615 LYS LYS A . n
A 1 594 PHE 594 616 616 PHE PHE A . n
A 1 595 PRO 595 617 617 PRO PRO A . n
A 1 596 ASP 596 618 618 ASP ASP A . n
A 1 597 GLU 597 619 619 GLU GLU A . n
A 1 598 GLU 598 620 620 GLU GLU A . n
A 1 599 GLY 599 621 621 GLY GLY A . n
A 1 600 ALA 600 622 622 ALA ALA A . n
A 1 601 CYS 601 623 623 CYS CYS A . n
A 1 602 GLN 602 624 624 GLN GLN A . n
A 1 603 PRO 603 625 625 PRO PRO A . n
A 1 604 CYS 604 626 626 CYS CYS A . n
A 1 605 PRO 605 627 627 PRO PRO A . n
A 1 606 ILE 606 628 628 ILE ILE A . n
A 1 607 ASN 607 629 629 ASN ASN A . n
A 1 608 CYS 608 630 630 CYS CYS A . n
A 1 609 THR 609 631 631 THR THR A . n
A 1 610 HIS 610 632 632 HIS HIS A . n
A 1 611 SER 611 633 633 SER SER A . n
A 1 612 CYS 612 634 634 CYS CYS A . n
A 1 613 VAL 613 635 635 VAL VAL A . n
A 1 614 ASP 614 636 636 ASP ASP A . n
A 1 615 LEU 615 637 637 LEU LEU A . n
A 1 616 ASP 616 638 638 ASP ASP A . n
A 1 617 ASP 617 639 639 ASP ASP A . n
A 1 618 LYS 618 640 640 LYS LYS A . n
A 1 619 GLY 619 641 641 GLY GLY A . n
A 1 620 CYS 620 642 642 CYS CYS A . n
A 1 621 PRO 621 643 643 PRO PRO A . n
A 1 622 ALA 622 644 644 ALA ALA A . n
B 2 1 ASP 1 1 1 ASP ASP B . n
B 2 2 ILE 2 2 2 ILE ILE B . n
B 2 3 GLN 3 3 3 GLN GLN B . n
B 2 4 MET 4 4 4 MET MET B . n
B 2 5 THR 5 5 5 THR THR B . n
B 2 6 GLN 6 6 6 GLN GLN B . n
B 2 7 SER 7 7 7 SER SER B . n
B 2 8 PRO 8 8 8 PRO PRO B . n
B 2 9 SER 9 9 9 SER SER B . n
B 2 10 SER 10 10 10 SER SER B . n
B 2 11 LEU 11 11 11 LEU LEU B . n
B 2 12 SER 12 12 12 SER SER B . n
B 2 13 ALA 13 13 13 ALA ALA B . n
B 2 14 SER 14 14 14 SER SER B . n
B 2 15 VAL 15 15 15 VAL VAL B . n
B 2 16 GLY 16 16 16 GLY GLY B . n
B 2 17 ASP 17 17 17 ASP ASP B . n
B 2 18 ARG 18 18 18 ARG ARG B . n
B 2 19 VAL 19 19 19 VAL VAL B . n
B 2 20 THR 20 20 20 THR THR B . n
B 2 21 ILE 21 21 21 ILE ILE B . n
B 2 22 THR 22 22 22 THR THR B . n
B 2 23 CYS 23 23 23 CYS CYS B . n
B 2 24 LYS 24 24 24 LYS LYS B . n
B 2 25 ALA 25 25 25 ALA ALA B . n
B 2 26 SER 26 26 26 SER SER B . n
B 2 27 GLN 27 27 27 GLN GLN B . n
B 2 28 ASP 28 28 28 ASP ASP B . n
B 2 29 VAL 29 29 29 VAL VAL B . n
B 2 30 SER 30 30 30 SER SER B . n
B 2 31 ILE 31 31 31 ILE ILE B . n
B 2 32 GLY 32 32 32 GLY GLY B . n
B 2 33 VAL 33 33 33 VAL VAL B . n
B 2 34 ALA 34 34 34 ALA ALA B . n
B 2 35 TRP 35 35 35 TRP TRP B . n
B 2 36 TYR 36 36 36 TYR TYR B . n
B 2 37 GLN 37 37 37 GLN GLN B . n
B 2 38 GLN 38 38 38 GLN GLN B . n
B 2 39 LYS 39 39 39 LYS LYS B . n
B 2 40 PRO 40 40 40 PRO PRO B . n
B 2 41 GLY 41 41 41 GLY GLY B . n
B 2 42 LYS 42 42 42 LYS LYS B . n
B 2 43 ALA 43 43 43 ALA ALA B . n
B 2 44 PRO 44 44 44 PRO PRO B . n
B 2 45 LYS 45 45 45 LYS LYS B . n
B 2 46 LEU 46 46 46 LEU LEU B . n
B 2 47 LEU 47 47 47 LEU LEU B . n
B 2 48 ILE 48 48 48 ILE ILE B . n
B 2 49 TYR 49 49 49 TYR TYR B . n
B 2 50 SER 50 50 50 SER SER B . n
B 2 51 ALA 51 51 51 ALA ALA B . n
B 2 52 SER 52 52 52 SER SER B . n
B 2 53 TYR 53 53 53 TYR TYR B . n
B 2 54 ARG 54 54 54 ARG ARG B . n
B 2 55 TYR 55 55 55 TYR TYR B . n
B 2 56 THR 56 56 56 THR THR B . n
B 2 57 GLY 57 57 57 GLY GLY B . n
B 2 58 VAL 58 58 58 VAL VAL B . n
B 2 59 PRO 59 59 59 PRO PRO B . n
B 2 60 SER 60 60 60 SER SER B . n
B 2 61 ARG 61 61 61 ARG ARG B . n
B 2 62 PHE 62 62 62 PHE PHE B . n
B 2 63 SER 63 63 63 SER SER B . n
B 2 64 GLY 64 64 64 GLY GLY B . n
B 2 65 SER 65 65 65 SER SER B . n
B 2 66 GLY 66 66 66 GLY GLY B . n
B 2 67 SER 67 67 67 SER SER B . n
B 2 68 GLY 68 68 68 GLY GLY B . n
B 2 69 THR 69 69 69 THR THR B . n
B 2 70 ASP 70 70 70 ASP ASP B . n
B 2 71 PHE 71 71 71 PHE PHE B . n
B 2 72 THR 72 72 72 THR THR B . n
B 2 73 LEU 73 73 73 LEU LEU B . n
B 2 74 THR 74 74 74 THR THR B . n
B 2 75 ILE 75 75 75 ILE ILE B . n
B 2 76 SER 76 76 76 SER SER B . n
B 2 77 SER 77 77 77 SER SER B . n
B 2 78 LEU 78 78 78 LEU LEU B . n
B 2 79 GLN 79 79 79 GLN GLN B . n
B 2 80 PRO 80 80 80 PRO PRO B . n
B 2 81 GLU 81 81 81 GLU GLU B . n
B 2 82 ASP 82 82 82 ASP ASP B . n
B 2 83 PHE 83 83 83 PHE PHE B . n
B 2 84 ALA 84 84 84 ALA ALA B . n
B 2 85 THR 85 85 85 THR THR B . n
B 2 86 TYR 86 86 86 TYR TYR B . n
B 2 87 TYR 87 87 87 TYR TYR B . n
B 2 88 CYS 88 88 88 CYS CYS B . n
B 2 89 GLN 89 89 89 GLN GLN B . n
B 2 90 GLN 90 90 90 GLN GLN B . n
B 2 91 TYR 91 91 91 TYR TYR B . n
B 2 92 TYR 92 92 92 TYR TYR B . n
B 2 93 ILE 93 93 93 ILE ILE B . n
B 2 94 TYR 94 94 94 TYR TYR B . n
B 2 95 PRO 95 95 95 PRO PRO B . n
B 2 96 TYR 96 96 96 TYR TYR B . n
B 2 97 THR 97 97 97 THR THR B . n
B 2 98 PHE 98 98 98 PHE PHE B . n
B 2 99 GLY 99 99 99 GLY GLY B . n
B 2 100 GLN 100 100 100 GLN GLN B . n
B 2 101 GLY 101 101 101 GLY GLY B . n
B 2 102 THR 102 102 102 THR THR B . n
B 2 103 LYS 103 103 103 LYS LYS B . n
B 2 104 VAL 104 104 104 VAL VAL B . n
B 2 105 GLU 105 105 105 GLU GLU B . n
B 2 106 ILE 106 106 106 ILE ILE B . n
B 2 107 LYS 107 107 107 LYS LYS B . n
B 2 108 ARG 108 108 108 ARG ARG B . n
B 2 109 THR 109 109 109 THR THR B . n
B 2 110 VAL 110 110 110 VAL VAL B . n
B 2 111 ALA 111 111 111 ALA ALA B . n
B 2 112 ALA 112 112 112 ALA ALA B . n
B 2 113 PRO 113 113 113 PRO PRO B . n
B 2 114 SER 114 114 114 SER SER B . n
B 2 115 VAL 115 115 115 VAL VAL B . n
B 2 116 PHE 116 116 116 PHE PHE B . n
B 2 117 ILE 117 117 117 ILE ILE B . n
B 2 118 PHE 118 118 118 PHE PHE B . n
B 2 119 PRO 119 119 119 PRO PRO B . n
B 2 120 PRO 120 120 120 PRO PRO B . n
B 2 121 SER 121 121 121 SER SER B . n
B 2 122 ASP 122 122 122 ASP ASP B . n
B 2 123 GLU 123 123 123 GLU GLU B . n
B 2 124 GLN 124 124 124 GLN GLN B . n
B 2 125 LEU 125 125 125 LEU LEU B . n
B 2 126 LYS 126 126 126 LYS LYS B . n
B 2 127 SER 127 127 127 SER SER B . n
B 2 128 GLY 128 128 128 GLY GLY B . n
B 2 129 THR 129 129 129 THR THR B . n
B 2 130 ALA 130 130 130 ALA ALA B . n
B 2 131 SER 131 131 131 SER SER B . n
B 2 132 VAL 132 132 132 VAL VAL B . n
B 2 133 VAL 133 133 133 VAL VAL B . n
B 2 134 CYS 134 134 134 CYS CYS B . n
B 2 135 LEU 135 135 135 LEU LEU B . n
B 2 136 LEU 136 136 136 LEU LEU B . n
B 2 137 ASN 137 137 137 ASN ASN B . n
B 2 138 ASN 138 138 138 ASN ASN B . n
B 2 139 PHE 139 139 139 PHE PHE B . n
B 2 140 TYR 140 140 140 TYR TYR B . n
B 2 141 PRO 141 141 141 PRO PRO B . n
B 2 142 ARG 142 142 142 ARG ARG B . n
B 2 143 GLU 143 143 143 GLU GLU B . n
B 2 144 ALA 144 144 144 ALA ALA B . n
B 2 145 LYS 145 145 145 LYS LYS B . n
B 2 146 VAL 146 146 146 VAL VAL B . n
B 2 147 GLN 147 147 147 GLN GLN B . n
B 2 148 TRP 148 148 148 TRP TRP B . n
B 2 149 LYS 149 149 149 LYS LYS B . n
B 2 150 VAL 150 150 150 VAL VAL B . n
B 2 151 ASP 151 151 151 ASP ASP B . n
B 2 152 ASN 152 152 152 ASN ASN B . n
B 2 153 ALA 153 153 153 ALA ALA B . n
B 2 154 LEU 154 154 154 LEU LEU B . n
B 2 155 GLN 155 155 155 GLN GLN B . n
B 2 156 SER 156 156 156 SER SER B . n
B 2 157 GLY 157 157 157 GLY GLY B . n
B 2 158 ASN 158 158 158 ASN ASN B . n
B 2 159 SER 159 159 159 SER SER B . n
B 2 160 GLN 160 160 160 GLN GLN B . n
B 2 161 GLU 161 161 161 GLU GLU B . n
B 2 162 SER 162 162 162 SER SER B . n
B 2 163 VAL 163 163 163 VAL VAL B . n
B 2 164 THR 164 164 164 THR THR B . n
B 2 165 GLU 165 165 165 GLU GLU B . n
B 2 166 GLN 166 166 166 GLN GLN B . n
B 2 167 ASP 167 167 167 ASP ASP B . n
B 2 168 SER 168 168 168 SER SER B . n
B 2 169 LYS 169 169 169 LYS LYS B . n
B 2 170 ASP 170 170 170 ASP ASP B . n
B 2 171 SER 171 171 171 SER SER B . n
B 2 172 THR 172 172 172 THR THR B . n
B 2 173 TYR 173 173 173 TYR TYR B . n
B 2 174 SER 174 174 174 SER SER B . n
B 2 175 LEU 175 175 175 LEU LEU B . n
B 2 176 SER 176 176 176 SER SER B . n
B 2 177 SER 177 177 177 SER SER B . n
B 2 178 THR 178 178 178 THR THR B . n
B 2 179 LEU 179 179 179 LEU LEU B . n
B 2 180 THR 180 180 180 THR THR B . n
B 2 181 LEU 181 181 181 LEU LEU B . n
B 2 182 SER 182 182 182 SER SER B . n
B 2 183 LYS 183 183 183 LYS LYS B . n
B 2 184 ALA 184 184 184 ALA ALA B . n
B 2 185 ASP 185 185 185 ASP ASP B . n
B 2 186 TYR 186 186 186 TYR TYR B . n
B 2 187 GLU 187 187 187 GLU GLU B . n
B 2 188 LYS 188 188 188 LYS LYS B . n
B 2 189 HIS 189 189 189 HIS HIS B . n
B 2 190 LYS 190 190 190 LYS LYS B . n
B 2 191 VAL 191 191 191 VAL VAL B . n
B 2 192 TYR 192 192 192 TYR TYR B . n
B 2 193 ALA 193 193 193 ALA ALA B . n
B 2 194 CYS 194 194 194 CYS CYS B . n
B 2 195 GLU 195 195 195 GLU GLU B . n
B 2 196 VAL 196 196 196 VAL VAL B . n
B 2 197 THR 197 197 197 THR THR B . n
B 2 198 HIS 198 198 198 HIS HIS B . n
B 2 199 GLN 199 199 199 GLN GLN B . n
B 2 200 GLY 200 200 200 GLY GLY B . n
B 2 201 LEU 201 201 201 LEU LEU B . n
B 2 202 SER 202 202 202 SER SER B . n
B 2 203 SER 203 203 203 SER SER B . n
B 2 204 PRO 204 204 204 PRO PRO B . n
B 2 205 VAL 205 205 205 VAL VAL B . n
B 2 206 THR 206 206 206 THR THR B . n
B 2 207 LYS 207 207 207 LYS LYS B . n
B 2 208 SER 208 208 208 SER SER B . n
B 2 209 PHE 209 209 209 PHE PHE B . n
B 2 210 ASN 210 210 210 ASN ASN B . n
B 2 211 ARG 211 211 211 ARG ARG B . n
B 2 212 GLY 212 212 212 GLY GLY B . n
B 2 213 GLU 213 213 213 GLU GLU B . n
B 2 214 CYS 214 214 214 CYS CYS B . n
C 3 1 GLU 1 1 1 GLU GLU C . n
C 3 2 VAL 2 2 2 VAL VAL C . n
C 3 3 GLN 3 3 3 GLN GLN C . n
C 3 4 LEU 4 4 4 LEU LEU C . n
C 3 5 VAL 5 5 5 VAL VAL C . n
C 3 6 GLU 6 6 6 GLU GLU C . n
C 3 7 SER 7 7 7 SER SER C . n
C 3 8 GLY 8 8 8 GLY GLY C . n
C 3 9 GLY 9 9 9 GLY GLY C . n
C 3 10 GLY 10 10 10 GLY GLY C . n
C 3 11 LEU 11 11 11 LEU LEU C . n
C 3 12 VAL 12 12 12 VAL VAL C . n
C 3 13 GLN 13 13 13 GLN GLN C . n
C 3 14 PRO 14 14 14 PRO PRO C . n
C 3 15 GLY 15 15 15 GLY GLY C . n
C 3 16 GLY 16 16 16 GLY GLY C . n
C 3 17 SER 17 17 17 SER SER C . n
C 3 18 LEU 18 18 18 LEU LEU C . n
C 3 19 ARG 19 19 19 ARG ARG C . n
C 3 20 LEU 20 20 20 LEU LEU C . n
C 3 21 SER 21 21 21 SER SER C . n
C 3 22 CYS 22 22 22 CYS CYS C . n
C 3 23 ALA 23 23 23 ALA ALA C . n
C 3 24 ALA 24 24 24 ALA ALA C . n
C 3 25 SER 25 25 25 SER SER C . n
C 3 26 GLY 26 26 26 GLY GLY C . n
C 3 27 PHE 27 27 27 PHE PHE C . n
C 3 28 THR 28 28 28 THR THR C . n
C 3 29 PHE 29 29 29 PHE PHE C . n
C 3 30 THR 30 30 30 THR THR C . n
C 3 31 ASP 31 31 31 ASP ASP C . n
C 3 32 TYR 32 32 32 TYR TYR C . n
C 3 33 THR 33 33 33 THR THR C . n
C 3 34 MET 34 34 34 MET MET C . n
C 3 35 ASP 35 35 35 ASP ASP C . n
C 3 36 TRP 36 36 36 TRP TRP C . n
C 3 37 VAL 37 37 37 VAL VAL C . n
C 3 38 ARG 38 38 38 ARG ARG C . n
C 3 39 GLN 39 39 39 GLN GLN C . n
C 3 40 ALA 40 40 40 ALA ALA C . n
C 3 41 PRO 41 41 41 PRO PRO C . n
C 3 42 GLY 42 42 42 GLY GLY C . n
C 3 43 LYS 43 43 43 LYS LYS C . n
C 3 44 GLY 44 44 44 GLY GLY C . n
C 3 45 LEU 45 45 45 LEU LEU C . n
C 3 46 GLU 46 46 46 GLU GLU C . n
C 3 47 TRP 47 47 47 TRP TRP C . n
C 3 48 VAL 48 48 48 VAL VAL C . n
C 3 49 ALA 49 49 49 ALA ALA C . n
C 3 50 ASP 50 50 50 ASP ASP C . n
C 3 51 VAL 51 51 51 VAL VAL C . n
C 3 52 ASN 52 52 52 ASN ASN C . n
C 3 53 PRO 53 52 52 PRO PRO C A n
C 3 54 ASN 54 53 53 ASN ASN C . n
C 3 55 SER 55 54 54 SER SER C . n
C 3 56 GLY 56 55 55 GLY GLY C . n
C 3 57 GLY 57 56 56 GLY GLY C . n
C 3 58 SER 58 57 57 SER SER C . n
C 3 59 ILE 59 58 58 ILE ILE C . n
C 3 60 TYR 60 59 59 TYR TYR C . n
C 3 61 ASN 61 60 60 ASN ASN C . n
C 3 62 GLN 62 61 61 GLN GLN C . n
C 3 63 ARG 63 62 62 ARG ARG C . n
C 3 64 PHE 64 63 63 PHE PHE C . n
C 3 65 LYS 65 64 64 LYS LYS C . n
C 3 66 GLY 66 65 65 GLY GLY C . n
C 3 67 ARG 67 66 66 ARG ARG C . n
C 3 68 PHE 68 67 67 PHE PHE C . n
C 3 69 THR 69 68 68 THR THR C . n
C 3 70 LEU 70 69 69 LEU LEU C . n
C 3 71 SER 71 70 70 SER SER C . n
C 3 72 VAL 72 71 71 VAL VAL C . n
C 3 73 ASP 73 72 72 ASP ASP C . n
C 3 74 ARG 74 73 73 ARG ARG C . n
C 3 75 SER 75 74 74 SER SER C . n
C 3 76 LYS 76 75 75 LYS LYS C . n
C 3 77 ASN 77 76 76 ASN ASN C . n
C 3 78 THR 78 77 77 THR THR C . n
C 3 79 LEU 79 78 78 LEU LEU C . n
C 3 80 TYR 80 79 79 TYR TYR C . n
C 3 81 LEU 81 80 80 LEU LEU C . n
C 3 82 GLN 82 81 81 GLN GLN C . n
C 3 83 MET 83 82 82 MET MET C . n
C 3 84 ASN 84 82 82 ASN ASN C A n
C 3 85 SER 85 82 82 SER SER C B n
C 3 86 LEU 86 82 82 LEU LEU C C n
C 3 87 ARG 87 83 83 ARG ARG C . n
C 3 88 ALA 88 84 84 ALA ALA C . n
C 3 89 GLU 89 85 85 GLU GLU C . n
C 3 90 ASP 90 86 86 ASP ASP C . n
C 3 91 THR 91 87 87 THR THR C . n
C 3 92 ALA 92 88 88 ALA ALA C . n
C 3 93 VAL 93 89 89 VAL VAL C . n
C 3 94 TYR 94 90 90 TYR TYR C . n
C 3 95 TYR 95 91 91 TYR TYR C . n
C 3 96 CYS 96 92 92 CYS CYS C . n
C 3 97 ALA 97 93 93 ALA ALA C . n
C 3 98 ARG 98 94 94 ARG ARG C . n
C 3 99 ASN 99 95 95 ASN ASN C . n
C 3 100 LEU 100 96 96 LEU LEU C . n
C 3 101 GLY 101 97 97 GLY GLY C . n
C 3 102 PRO 102 98 98 PRO PRO C . n
C 3 103 SER 103 99 99 SER SER C . n
C 3 104 PHE 104 99 99 PHE PHE C A n
C 3 105 TYR 105 99 99 TYR TYR C B n
C 3 106 PHE 106 100 100 PHE PHE C . n
C 3 107 ASP 107 101 101 ASP ASP C . n
C 3 108 TYR 108 102 102 TYR TYR C . n
C 3 109 TRP 109 103 103 TRP TRP C . n
C 3 110 GLY 110 104 104 GLY GLY C . n
C 3 111 GLN 111 105 105 GLN GLN C . n
C 3 112 GLY 112 106 106 GLY GLY C . n
C 3 113 THR 113 107 107 THR THR C . n
C 3 114 LEU 114 108 108 LEU LEU C . n
C 3 115 VAL 115 109 109 VAL VAL C . n
C 3 116 THR 116 110 110 THR THR C . n
C 3 117 VAL 117 111 111 VAL VAL C . n
C 3 118 SER 118 112 112 SER SER C . n
C 3 119 SER 119 113 113 SER SER C . n
C 3 120 ALA 120 114 114 ALA ALA C . n
C 3 121 SER 121 115 115 SER SER C . n
C 3 122 THR 122 116 116 THR THR C . n
C 3 123 LYS 123 117 117 LYS LYS C . n
C 3 124 GLY 124 118 118 GLY GLY C . n
C 3 125 PRO 125 119 119 PRO PRO C . n
C 3 126 SER 126 120 120 SER SER C . n
C 3 127 VAL 127 121 121 VAL VAL C . n
C 3 128 PHE 128 122 122 PHE PHE C . n
C 3 129 PRO 129 123 123 PRO PRO C . n
C 3 130 LEU 130 124 124 LEU LEU C . n
C 3 131 ALA 131 125 125 ALA ALA C . n
C 3 132 PRO 132 126 126 PRO PRO C . n
C 3 133 SER 133 127 127 SER SER C . n
C 3 134 SER 134 128 128 SER SER C . n
C 3 135 LYS 135 129 129 LYS LYS C . n
C 3 136 SER 136 130 130 SER SER C . n
C 3 137 THR 137 131 131 THR THR C . n
C 3 138 SER 138 132 132 SER SER C . n
C 3 139 GLY 139 133 133 GLY GLY C . n
C 3 140 GLY 140 134 134 GLY GLY C . n
C 3 141 THR 141 135 135 THR THR C . n
C 3 142 ALA 142 136 136 ALA ALA C . n
C 3 143 ALA 143 137 137 ALA ALA C . n
C 3 144 LEU 144 138 138 LEU LEU C . n
C 3 145 GLY 145 139 139 GLY GLY C . n
C 3 146 CYS 146 140 140 CYS CYS C . n
C 3 147 LEU 147 141 141 LEU LEU C . n
C 3 148 VAL 148 142 142 VAL VAL C . n
C 3 149 LYS 149 143 143 LYS LYS C . n
C 3 150 ASP 150 144 144 ASP ASP C . n
C 3 151 TYR 151 145 145 TYR TYR C . n
C 3 152 PHE 152 146 146 PHE PHE C . n
C 3 153 PRO 153 147 147 PRO PRO C . n
C 3 154 GLU 154 148 148 GLU GLU C . n
C 3 155 PRO 155 149 149 PRO PRO C . n
C 3 156 VAL 156 150 150 VAL VAL C . n
C 3 157 THR 157 151 151 THR THR C . n
C 3 158 VAL 158 152 152 VAL VAL C . n
C 3 159 SER 159 153 153 SER SER C . n
C 3 160 TRP 160 154 154 TRP TRP C . n
C 3 161 ASN 161 155 155 ASN ASN C . n
C 3 162 SER 162 156 156 SER SER C . n
C 3 163 GLY 163 157 157 GLY GLY C . n
C 3 164 ALA 164 158 158 ALA ALA C . n
C 3 165 LEU 165 159 159 LEU LEU C . n
C 3 166 THR 166 160 160 THR THR C . n
C 3 167 SER 167 161 161 SER SER C . n
C 3 168 GLY 168 162 162 GLY GLY C . n
C 3 169 VAL 169 163 163 VAL VAL C . n
C 3 170 HIS 170 164 164 HIS HIS C . n
C 3 171 THR 171 165 165 THR THR C . n
C 3 172 PHE 172 166 166 PHE PHE C . n
C 3 173 PRO 173 167 167 PRO PRO C . n
C 3 174 ALA 174 168 168 ALA ALA C . n
C 3 175 VAL 175 169 169 VAL VAL C . n
C 3 176 LEU 176 170 170 LEU LEU C . n
C 3 177 GLN 177 171 171 GLN GLN C . n
C 3 178 SER 178 172 172 SER SER C . n
C 3 179 SER 179 173 173 SER SER C . n
C 3 180 GLY 180 174 174 GLY GLY C . n
C 3 181 LEU 181 175 175 LEU LEU C . n
C 3 182 TYR 182 176 176 TYR TYR C . n
C 3 183 SER 183 177 177 SER SER C . n
C 3 184 LEU 184 178 178 LEU LEU C . n
C 3 185 SER 185 179 179 SER SER C . n
C 3 186 SER 186 180 180 SER SER C . n
C 3 187 VAL 187 181 181 VAL VAL C . n
C 3 188 VAL 188 182 182 VAL VAL C . n
C 3 189 THR 189 183 183 THR THR C . n
C 3 190 VAL 190 184 184 VAL VAL C . n
C 3 191 PRO 191 185 185 PRO PRO C . n
C 3 192 SER 192 186 186 SER SER C . n
C 3 193 SER 193 187 187 SER SER C . n
C 3 194 SER 194 188 188 SER SER C . n
C 3 195 LEU 195 189 189 LEU LEU C . n
C 3 196 GLY 196 190 190 GLY GLY C . n
C 3 197 THR 197 191 191 THR THR C . n
C 3 198 GLN 198 192 192 GLN GLN C . n
C 3 199 THR 199 193 193 THR THR C . n
C 3 200 TYR 200 194 194 TYR TYR C . n
C 3 201 ILE 201 195 195 ILE ILE C . n
C 3 202 CYS 202 196 196 CYS CYS C . n
C 3 203 ASN 203 197 197 ASN ASN C . n
C 3 204 VAL 204 198 198 VAL VAL C . n
C 3 205 ASN 205 199 199 ASN ASN C . n
C 3 206 HIS 206 200 200 HIS HIS C . n
C 3 207 LYS 207 201 201 LYS LYS C . n
C 3 208 PRO 208 202 202 PRO PRO C . n
C 3 209 SER 209 203 203 SER SER C . n
C 3 210 ASN 210 204 204 ASN ASN C . n
C 3 211 THR 211 205 205 THR THR C . n
C 3 212 LYS 212 206 206 LYS LYS C . n
C 3 213 VAL 213 207 207 VAL VAL C . n
C 3 214 ASP 214 208 208 ASP ASP C . n
C 3 215 LYS 215 209 209 LYS LYS C . n
C 3 216 LYS 216 210 210 LYS LYS C . n
C 3 217 VAL 217 211 211 VAL VAL C . n
C 3 218 GLU 218 212 212 GLU GLU C . n
C 3 219 PRO 219 213 213 PRO PRO C . n
C 3 220 LYS 220 214 214 LYS LYS C . n
C 3 221 SER 221 215 215 SER SER C . n
C 3 222 CYS 222 216 216 CYS CYS C . n
D 4 1 ASP 1 1 1 ASP ASP D . n
D 4 2 ILE 2 2 2 ILE ILE D . n
D 4 3 GLN 3 3 3 GLN GLN D . n
D 4 4 MET 4 4 4 MET MET D . n
D 4 5 THR 5 5 5 THR THR D . n
D 4 6 GLN 6 6 6 GLN GLN D . n
D 4 7 SER 7 7 7 SER SER D . n
D 4 8 PRO 8 8 8 PRO PRO D . n
D 4 9 SER 9 9 9 SER SER D . n
D 4 10 SER 10 10 10 SER SER D . n
D 4 11 LEU 11 11 11 LEU LEU D . n
D 4 12 SER 12 12 12 SER SER D . n
D 4 13 ALA 13 13 13 ALA ALA D . n
D 4 14 SER 14 14 14 SER SER D . n
D 4 15 VAL 15 15 15 VAL VAL D . n
D 4 16 GLY 16 16 16 GLY GLY D . n
D 4 17 ASP 17 17 17 ASP ASP D . n
D 4 18 ARG 18 18 18 ARG ARG D . n
D 4 19 VAL 19 19 19 VAL VAL D . n
D 4 20 THR 20 20 20 THR THR D . n
D 4 21 ILE 21 21 21 ILE ILE D . n
D 4 22 THR 22 22 22 THR THR D . n
D 4 23 CYS 23 23 23 CYS CYS D . n
D 4 24 ARG 24 24 24 ARG ARG D . n
D 4 25 ALA 25 25 25 ALA ALA D . n
D 4 26 SER 26 26 26 SER SER D . n
D 4 27 GLN 27 27 27 GLN GLN D . n
D 4 28 ASP 28 28 28 ASP ASP D . n
D 4 29 VAL 29 29 29 VAL VAL D . n
D 4 30 ASN 30 30 30 ASN ASN D . n
D 4 31 THR 31 31 31 THR THR D . n
D 4 32 ALA 32 32 32 ALA ALA D . n
D 4 33 VAL 33 33 33 VAL VAL D . n
D 4 34 ALA 34 34 34 ALA ALA D . n
D 4 35 TRP 35 35 35 TRP TRP D . n
D 4 36 TYR 36 36 36 TYR TYR D . n
D 4 37 GLN 37 37 37 GLN GLN D . n
D 4 38 GLN 38 38 38 GLN GLN D . n
D 4 39 LYS 39 39 39 LYS LYS D . n
D 4 40 PRO 40 40 40 PRO PRO D . n
D 4 41 GLY 41 41 41 GLY GLY D . n
D 4 42 LYS 42 42 42 LYS LYS D . n
D 4 43 ALA 43 43 43 ALA ALA D . n
D 4 44 PRO 44 44 44 PRO PRO D . n
D 4 45 LYS 45 45 45 LYS LYS D . n
D 4 46 LEU 46 46 46 LEU LEU D . n
D 4 47 LEU 47 47 47 LEU LEU D . n
D 4 48 ILE 48 48 48 ILE ILE D . n
D 4 49 TYR 49 49 49 TYR TYR D . n
D 4 50 SER 50 50 50 SER SER D . n
D 4 51 ALA 51 51 51 ALA ALA D . n
D 4 52 SER 52 52 52 SER SER D . n
D 4 53 PHE 53 53 53 PHE PHE D . n
D 4 54 LEU 54 54 54 LEU LEU D . n
D 4 55 TYR 55 55 55 TYR TYR D . n
D 4 56 SER 56 56 56 SER SER D . n
D 4 57 GLY 57 57 57 GLY GLY D . n
D 4 58 VAL 58 58 58 VAL VAL D . n
D 4 59 PRO 59 59 59 PRO PRO D . n
D 4 60 SER 60 60 60 SER SER D . n
D 4 61 ARG 61 61 61 ARG ARG D . n
D 4 62 PHE 62 62 62 PHE PHE D . n
D 4 63 SER 63 63 63 SER SER D . n
D 4 64 GLY 64 64 64 GLY GLY D . n
D 4 65 SER 65 65 65 SER SER D . n
D 4 66 ARG 66 66 66 ARG ARG D . n
D 4 67 SER 67 67 67 SER SER D . n
D 4 68 GLY 68 68 68 GLY GLY D . n
D 4 69 THR 69 69 69 THR THR D . n
D 4 70 ASP 70 70 70 ASP ASP D . n
D 4 71 PHE 71 71 71 PHE PHE D . n
D 4 72 THR 72 72 72 THR THR D . n
D 4 73 LEU 73 73 73 LEU LEU D . n
D 4 74 THR 74 74 74 THR THR D . n
D 4 75 ILE 75 75 75 ILE ILE D . n
D 4 76 SER 76 76 76 SER SER D . n
D 4 77 SER 77 77 77 SER SER D . n
D 4 78 LEU 78 78 78 LEU LEU D . n
D 4 79 GLN 79 79 79 GLN GLN D . n
D 4 80 PRO 80 80 80 PRO PRO D . n
D 4 81 GLU 81 81 81 GLU GLU D . n
D 4 82 ASP 82 82 82 ASP ASP D . n
D 4 83 PHE 83 83 83 PHE PHE D . n
D 4 84 ALA 84 84 84 ALA ALA D . n
D 4 85 THR 85 85 85 THR THR D . n
D 4 86 TYR 86 86 86 TYR TYR D . n
D 4 87 TYR 87 87 87 TYR TYR D . n
D 4 88 CYS 88 88 88 CYS CYS D . n
D 4 89 GLN 89 89 89 GLN GLN D . n
D 4 90 GLN 90 90 90 GLN GLN D . n
D 4 91 HIS 91 91 91 HIS HIS D . n
D 4 92 TYR 92 92 92 TYR TYR D . n
D 4 93 THR 93 93 93 THR THR D . n
D 4 94 THR 94 94 94 THR THR D . n
D 4 95 PRO 95 95 95 PRO PRO D . n
D 4 96 PRO 96 96 96 PRO PRO D . n
D 4 97 THR 97 97 97 THR THR D . n
D 4 98 PHE 98 98 98 PHE PHE D . n
D 4 99 GLY 99 99 99 GLY GLY D . n
D 4 100 GLN 100 100 100 GLN GLN D . n
D 4 101 GLY 101 101 101 GLY GLY D . n
D 4 102 THR 102 102 102 THR THR D . n
D 4 103 LYS 103 103 103 LYS LYS D . n
D 4 104 VAL 104 104 104 VAL VAL D . n
D 4 105 GLU 105 105 105 GLU GLU D . n
D 4 106 ILE 106 106 106 ILE ILE D . n
D 4 107 LYS 107 107 107 LYS LYS D . n
D 4 108 ARG 108 108 108 ARG ARG D . n
D 4 109 THR 109 109 109 THR THR D . n
D 4 110 VAL 110 110 110 VAL VAL D . n
D 4 111 ALA 111 111 111 ALA ALA D . n
D 4 112 ALA 112 112 112 ALA ALA D . n
D 4 113 PRO 113 113 113 PRO PRO D . n
D 4 114 SER 114 114 114 SER SER D . n
D 4 115 VAL 115 115 115 VAL VAL D . n
D 4 116 PHE 116 116 116 PHE PHE D . n
D 4 117 ILE 117 117 117 ILE ILE D . n
D 4 118 PHE 118 118 118 PHE PHE D . n
D 4 119 PRO 119 119 119 PRO PRO D . n
D 4 120 PRO 120 120 120 PRO PRO D . n
D 4 121 SER 121 121 121 SER SER D . n
D 4 122 ASP 122 122 122 ASP ASP D . n
D 4 123 GLU 123 123 123 GLU GLU D . n
D 4 124 GLN 124 124 124 GLN GLN D . n
D 4 125 LEU 125 125 125 LEU LEU D . n
D 4 126 LYS 126 126 126 LYS LYS D . n
D 4 127 SER 127 127 127 SER SER D . n
D 4 128 GLY 128 128 128 GLY GLY D . n
D 4 129 THR 129 129 129 THR THR D . n
D 4 130 ALA 130 130 130 ALA ALA D . n
D 4 131 SER 131 131 131 SER SER D . n
D 4 132 VAL 132 132 132 VAL VAL D . n
D 4 133 VAL 133 133 133 VAL VAL D . n
D 4 134 CYS 134 134 134 CYS CYS D . n
D 4 135 LEU 135 135 135 LEU LEU D . n
D 4 136 LEU 136 136 136 LEU LEU D . n
D 4 137 ASN 137 137 137 ASN ASN D . n
D 4 138 ASN 138 138 138 ASN ASN D . n
D 4 139 PHE 139 139 139 PHE PHE D . n
D 4 140 TYR 140 140 140 TYR TYR D . n
D 4 141 PRO 141 141 141 PRO PRO D . n
D 4 142 ARG 142 142 142 ARG ARG D . n
D 4 143 GLU 143 143 143 GLU GLU D . n
D 4 144 ALA 144 144 144 ALA ALA D . n
D 4 145 LYS 145 145 145 LYS LYS D . n
D 4 146 VAL 146 146 146 VAL VAL D . n
D 4 147 GLN 147 147 147 GLN GLN D . n
D 4 148 TRP 148 148 148 TRP TRP D . n
D 4 149 LYS 149 149 149 LYS LYS D . n
D 4 150 VAL 150 150 150 VAL VAL D . n
D 4 151 ASP 151 151 151 ASP ASP D . n
D 4 152 ASN 152 152 152 ASN ASN D . n
D 4 153 ALA 153 153 153 ALA ALA D . n
D 4 154 LEU 154 154 154 LEU LEU D . n
D 4 155 GLN 155 155 155 GLN GLN D . n
D 4 156 SER 156 156 156 SER SER D . n
D 4 157 GLY 157 157 157 GLY GLY D . n
D 4 158 ASN 158 158 158 ASN ASN D . n
D 4 159 SER 159 159 159 SER SER D . n
D 4 160 GLN 160 160 160 GLN GLN D . n
D 4 161 GLU 161 161 161 GLU GLU D . n
D 4 162 SER 162 162 162 SER SER D . n
D 4 163 VAL 163 163 163 VAL VAL D . n
D 4 164 THR 164 164 164 THR THR D . n
D 4 165 GLU 165 165 165 GLU GLU D . n
D 4 166 GLN 166 166 166 GLN GLN D . n
D 4 167 ASP 167 167 167 ASP ASP D . n
D 4 168 SER 168 168 168 SER SER D . n
D 4 169 LYS 169 169 169 LYS LYS D . n
D 4 170 ASP 170 170 170 ASP ASP D . n
D 4 171 SER 171 171 171 SER SER D . n
D 4 172 THR 172 172 172 THR THR D . n
D 4 173 TYR 173 173 173 TYR TYR D . n
D 4 174 SER 174 174 174 SER SER D . n
D 4 175 LEU 175 175 175 LEU LEU D . n
D 4 176 SER 176 176 176 SER SER D . n
D 4 177 SER 177 177 177 SER SER D . n
D 4 178 THR 178 178 178 THR THR D . n
D 4 179 LEU 179 179 179 LEU LEU D . n
D 4 180 THR 180 180 180 THR THR D . n
D 4 181 LEU 181 181 181 LEU LEU D . n
D 4 182 SER 182 182 182 SER SER D . n
D 4 183 LYS 183 183 183 LYS LYS D . n
D 4 184 ALA 184 184 184 ALA ALA D . n
D 4 185 ASP 185 185 185 ASP ASP D . n
D 4 186 TYR 186 186 186 TYR TYR D . n
D 4 187 GLU 187 187 187 GLU GLU D . n
D 4 188 LYS 188 188 188 LYS LYS D . n
D 4 189 HIS 189 189 189 HIS HIS D . n
D 4 190 LYS 190 190 190 LYS LYS D . n
D 4 191 VAL 191 191 191 VAL VAL D . n
D 4 192 TYR 192 192 192 TYR TYR D . n
D 4 193 ALA 193 193 193 ALA ALA D . n
D 4 194 CYS 194 194 194 CYS CYS D . n
D 4 195 GLU 195 195 195 GLU GLU D . n
D 4 196 VAL 196 196 196 VAL VAL D . n
D 4 197 THR 197 197 197 THR THR D . n
D 4 198 HIS 198 198 198 HIS HIS D . n
D 4 199 GLN 199 199 199 GLN GLN D . n
D 4 200 GLY 200 200 200 GLY GLY D . n
D 4 201 LEU 201 201 201 LEU LEU D . n
D 4 202 SER 202 202 202 SER SER D . n
D 4 203 SER 203 203 203 SER SER D . n
D 4 204 PRO 204 204 204 PRO PRO D . n
D 4 205 VAL 205 205 205 VAL VAL D . n
D 4 206 THR 206 206 206 THR THR D . n
D 4 207 LYS 207 207 207 LYS LYS D . n
D 4 208 SER 208 208 208 SER SER D . n
D 4 209 PHE 209 209 209 PHE PHE D . n
D 4 210 ASN 210 210 210 ASN ASN D . n
D 4 211 ARG 211 211 211 ARG ARG D . n
D 4 212 GLY 212 212 212 GLY GLY D . n
D 4 213 GLU 213 213 213 GLU GLU D . n
D 4 214 CYS 214 214 214 CYS CYS D . n
E 5 1 GLU 1 1 1 GLU GLU E . n
E 5 2 VAL 2 2 2 VAL VAL E . n
E 5 3 GLN 3 3 3 GLN GLN E . n
E 5 4 LEU 4 4 4 LEU LEU E . n
E 5 5 VAL 5 5 5 VAL VAL E . n
E 5 6 GLU 6 6 6 GLU GLU E . n
E 5 7 SER 7 7 7 SER SER E . n
E 5 8 GLY 8 8 8 GLY GLY E . n
E 5 9 GLY 9 9 9 GLY GLY E . n
E 5 10 GLY 10 10 10 GLY GLY E . n
E 5 11 LEU 11 11 11 LEU LEU E . n
E 5 12 VAL 12 12 12 VAL VAL E . n
E 5 13 GLN 13 13 13 GLN GLN E . n
E 5 14 PRO 14 14 14 PRO PRO E . n
E 5 15 GLY 15 15 15 GLY GLY E . n
E 5 16 GLY 16 16 16 GLY GLY E . n
E 5 17 SER 17 17 17 SER SER E . n
E 5 18 LEU 18 18 18 LEU LEU E . n
E 5 19 ARG 19 19 19 ARG ARG E . n
E 5 20 LEU 20 20 20 LEU LEU E . n
E 5 21 SER 21 21 21 SER SER E . n
E 5 22 CYS 22 22 22 CYS CYS E . n
E 5 23 ALA 23 23 23 ALA ALA E . n
E 5 24 ALA 24 24 24 ALA ALA E . n
E 5 25 SER 25 25 25 SER SER E . n
E 5 26 GLY 26 26 26 GLY GLY E . n
E 5 27 PHE 27 27 27 PHE PHE E . n
E 5 28 ASN 28 28 28 ASN ASN E . n
E 5 29 ILE 29 29 29 ILE ILE E . n
E 5 30 LYS 30 30 30 LYS LYS E . n
E 5 31 ASP 31 31 31 ASP ASP E . n
E 5 32 THR 32 32 32 THR THR E . n
E 5 33 TYR 33 33 33 TYR TYR E . n
E 5 34 ILE 34 34 34 ILE ILE E . n
E 5 35 HIS 35 35 35 HIS HIS E . n
E 5 36 TRP 36 36 36 TRP TRP E . n
E 5 37 VAL 37 37 37 VAL VAL E . n
E 5 38 ARG 38 38 38 ARG ARG E . n
E 5 39 GLN 39 39 39 GLN GLN E . n
E 5 40 ALA 40 40 40 ALA ALA E . n
E 5 41 PRO 41 41 41 PRO PRO E . n
E 5 42 GLY 42 42 42 GLY GLY E . n
E 5 43 LYS 43 43 43 LYS LYS E . n
E 5 44 GLY 44 44 44 GLY GLY E . n
E 5 45 LEU 45 45 45 LEU LEU E . n
E 5 46 GLU 46 46 46 GLU GLU E . n
E 5 47 TRP 47 47 47 TRP TRP E . n
E 5 48 VAL 48 48 48 VAL VAL E . n
E 5 49 ALA 49 49 49 ALA ALA E . n
E 5 50 ARG 50 50 50 ARG ARG E . n
E 5 51 ILE 51 51 51 ILE ILE E . n
E 5 52 TYR 52 52 52 TYR TYR E . n
E 5 53 PRO 53 53 53 PRO PRO E . n
E 5 54 THR 54 54 54 THR THR E . n
E 5 55 ASN 55 55 55 ASN ASN E . n
E 5 56 GLY 56 56 56 GLY GLY E . n
E 5 57 TYR 57 57 57 TYR TYR E . n
E 5 58 THR 58 58 58 THR THR E . n
E 5 59 ARG 59 59 59 ARG ARG E . n
E 5 60 TYR 60 60 60 TYR TYR E . n
E 5 61 ALA 61 61 61 ALA ALA E . n
E 5 62 ASP 62 62 62 ASP ASP E . n
E 5 63 SER 63 63 63 SER SER E . n
E 5 64 VAL 64 64 64 VAL VAL E . n
E 5 65 LYS 65 65 65 LYS LYS E . n
E 5 66 GLY 66 66 66 GLY GLY E . n
E 5 67 ARG 67 67 67 ARG ARG E . n
E 5 68 PHE 68 68 68 PHE PHE E . n
E 5 69 THR 69 69 69 THR THR E . n
E 5 70 ILE 70 70 70 ILE ILE E . n
E 5 71 SER 71 71 71 SER SER E . n
E 5 72 ALA 72 72 72 ALA ALA E . n
E 5 73 ASP 73 73 73 ASP ASP E . n
E 5 74 THR 74 74 74 THR THR E . n
E 5 75 SER 75 75 75 SER SER E . n
E 5 76 LYS 76 76 76 LYS LYS E . n
E 5 77 ASN 77 77 77 ASN ASN E . n
E 5 78 THR 78 78 78 THR THR E . n
E 5 79 ALA 79 79 79 ALA ALA E . n
E 5 80 TYR 80 80 80 TYR TYR E . n
E 5 81 LEU 81 81 81 LEU LEU E . n
E 5 82 GLN 82 82 82 GLN GLN E . n
E 5 83 MET 83 83 83 MET MET E . n
E 5 84 ASN 84 84 84 ASN ASN E . n
E 5 85 SER 85 85 85 SER SER E . n
E 5 86 LEU 86 86 86 LEU LEU E . n
E 5 87 ARG 87 87 87 ARG ARG E . n
E 5 88 ALA 88 88 88 ALA ALA E . n
E 5 89 GLU 89 89 89 GLU GLU E . n
E 5 90 ASP 90 90 90 ASP ASP E . n
E 5 91 THR 91 91 91 THR THR E . n
E 5 92 ALA 92 92 92 ALA ALA E . n
E 5 93 VAL 93 93 93 VAL VAL E . n
E 5 94 TYR 94 94 94 TYR TYR E . n
E 5 95 TYR 95 95 95 TYR TYR E . n
E 5 96 CYS 96 96 96 CYS CYS E . n
E 5 97 SER 97 97 97 SER SER E . n
E 5 98 ARG 98 98 98 ARG ARG E . n
E 5 99 TRP 99 99 99 TRP TRP E . n
E 5 100 GLY 100 100 100 GLY GLY E . n
E 5 101 GLY 101 101 101 GLY GLY E . n
E 5 102 ASP 102 102 102 ASP ASP E . n
E 5 103 GLY 103 103 103 GLY GLY E . n
E 5 104 PHE 104 104 104 PHE PHE E . n
E 5 105 TYR 105 105 105 TYR TYR E . n
E 5 106 ALA 106 106 106 ALA ALA E . n
E 5 107 MET 107 107 107 MET MET E . n
E 5 108 ASP 108 108 108 ASP ASP E . n
E 5 109 TYR 109 109 109 TYR TYR E . n
E 5 110 TRP 110 110 110 TRP TRP E . n
E 5 111 GLY 111 111 111 GLY GLY E . n
E 5 112 GLN 112 112 112 GLN GLN E . n
E 5 113 GLY 113 113 113 GLY GLY E . n
E 5 114 THR 114 114 114 THR THR E . n
E 5 115 LEU 115 115 115 LEU LEU E . n
E 5 116 VAL 116 116 116 VAL VAL E . n
E 5 117 THR 117 117 117 THR THR E . n
E 5 118 VAL 118 118 118 VAL VAL E . n
E 5 119 SER 119 119 119 SER SER E . n
E 5 120 SER 120 120 120 SER SER E . n
E 5 121 ALA 121 121 121 ALA ALA E . n
E 5 122 SER 122 122 122 SER SER E . n
E 5 123 THR 123 123 123 THR THR E . n
E 5 124 LYS 124 124 124 LYS LYS E . n
E 5 125 GLY 125 125 125 GLY GLY E . n
E 5 126 PRO 126 126 126 PRO PRO E . n
E 5 127 SER 127 127 127 SER SER E . n
E 5 128 VAL 128 128 128 VAL VAL E . n
E 5 129 PHE 129 129 129 PHE PHE E . n
E 5 130 PRO 130 130 130 PRO PRO E . n
E 5 131 LEU 131 131 131 LEU LEU E . n
E 5 132 ALA 132 132 132 ALA ALA E . n
E 5 133 PRO 133 133 133 PRO PRO E . n
E 5 134 SER 134 134 134 SER SER E . n
E 5 135 SER 135 135 135 SER SER E . n
E 5 136 LYS 136 136 136 LYS LYS E . n
E 5 137 SER 137 137 137 SER SER E . n
E 5 138 THR 138 138 138 THR THR E . n
E 5 139 SER 139 139 139 SER SER E . n
E 5 140 GLY 140 140 140 GLY GLY E . n
E 5 141 GLY 141 141 141 GLY GLY E . n
E 5 142 THR 142 142 142 THR THR E . n
E 5 143 ALA 143 143 143 ALA ALA E . n
E 5 144 ALA 144 144 144 ALA ALA E . n
E 5 145 LEU 145 145 145 LEU LEU E . n
E 5 146 GLY 146 146 146 GLY GLY E . n
E 5 147 CYS 147 147 147 CYS CYS E . n
E 5 148 LEU 148 148 148 LEU LEU E . n
E 5 149 VAL 149 149 149 VAL VAL E . n
E 5 150 LYS 150 150 150 LYS LYS E . n
E 5 151 ASP 151 151 151 ASP ASP E . n
E 5 152 TYR 152 152 152 TYR TYR E . n
E 5 153 PHE 153 153 153 PHE PHE E . n
E 5 154 PRO 154 154 154 PRO PRO E . n
E 5 155 GLU 155 155 155 GLU GLU E . n
E 5 156 PRO 156 156 156 PRO PRO E . n
E 5 157 VAL 157 157 157 VAL VAL E . n
E 5 158 THR 158 158 158 THR THR E . n
E 5 159 VAL 159 159 159 VAL VAL E . n
E 5 160 SER 160 160 160 SER SER E . n
E 5 161 TRP 161 161 161 TRP TRP E . n
E 5 162 ASN 162 162 162 ASN ASN E . n
E 5 163 SER 163 163 163 SER SER E . n
E 5 164 GLY 164 164 164 GLY GLY E . n
E 5 165 ALA 165 165 165 ALA ALA E . n
E 5 166 LEU 166 166 166 LEU LEU E . n
E 5 167 THR 167 167 167 THR THR E . n
E 5 168 SER 168 168 168 SER SER E . n
E 5 169 GLY 169 169 169 GLY GLY E . n
E 5 170 VAL 170 170 170 VAL VAL E . n
E 5 171 HIS 171 171 171 HIS HIS E . n
E 5 172 THR 172 172 172 THR THR E . n
E 5 173 PHE 173 173 173 PHE PHE E . n
E 5 174 PRO 174 174 174 PRO PRO E . n
E 5 175 ALA 175 175 175 ALA ALA E . n
E 5 176 VAL 176 176 176 VAL VAL E . n
E 5 177 LEU 177 177 177 LEU LEU E . n
E 5 178 GLN 178 178 178 GLN GLN E . n
E 5 179 SER 179 179 179 SER SER E . n
E 5 180 SER 180 180 180 SER SER E . n
E 5 181 GLY 181 181 181 GLY GLY E . n
E 5 182 LEU 182 182 182 LEU LEU E . n
E 5 183 TYR 183 183 183 TYR TYR E . n
E 5 184 SER 184 184 184 SER SER E . n
E 5 185 LEU 185 185 185 LEU LEU E . n
E 5 186 SER 186 186 186 SER SER E . n
E 5 187 SER 187 187 187 SER SER E . n
E 5 188 VAL 188 188 188 VAL VAL E . n
E 5 189 VAL 189 189 189 VAL VAL E . n
E 5 190 THR 190 190 190 THR THR E . n
E 5 191 VAL 191 191 191 VAL VAL E . n
E 5 192 PRO 192 192 192 PRO PRO E . n
E 5 193 SER 193 193 193 SER SER E . n
E 5 194 SER 194 194 194 SER SER E . n
E 5 195 SER 195 195 195 SER SER E . n
E 5 196 LEU 196 196 196 LEU LEU E . n
E 5 197 GLY 197 197 197 GLY GLY E . n
E 5 198 THR 198 198 198 THR THR E . n
E 5 199 GLN 199 199 199 GLN GLN E . n
E 5 200 THR 200 200 200 THR THR E . n
E 5 201 TYR 201 201 201 TYR TYR E . n
E 5 202 ILE 202 202 202 ILE ILE E . n
E 5 203 CYS 203 203 203 CYS CYS E . n
E 5 204 ASN 204 204 204 ASN ASN E . n
E 5 205 VAL 205 205 205 VAL VAL E . n
E 5 206 ASN 206 206 206 ASN ASN E . n
E 5 207 HIS 207 207 207 HIS HIS E . n
E 5 208 LYS 208 208 208 LYS LYS E . n
E 5 209 PRO 209 209 209 PRO PRO E . n
E 5 210 SER 210 210 210 SER SER E . n
E 5 211 ASN 211 211 211 ASN ASN E . n
E 5 212 THR 212 212 212 THR THR E . n
E 5 213 LYS 213 213 213 LYS LYS E . n
E 5 214 VAL 214 214 214 VAL VAL E . n
E 5 215 ASP 215 215 215 ASP ASP E . n
E 5 216 LYS 216 216 216 LYS LYS E . n
E 5 217 LYS 217 217 217 LYS LYS E . n
E 5 218 VAL 218 218 218 VAL VAL E . n
E 5 219 GLU 219 219 219 GLU GLU E . n
E 5 220 PRO 220 220 220 PRO PRO E . n
#
loop_
_pdbx_branch_scheme.asym_id
_pdbx_branch_scheme.entity_id
_pdbx_branch_scheme.mon_id
_pdbx_branch_scheme.num
_pdbx_branch_scheme.pdb_asym_id
_pdbx_branch_scheme.pdb_mon_id
_pdbx_branch_scheme.pdb_seq_num
_pdbx_branch_scheme.auth_asym_id
_pdbx_branch_scheme.auth_mon_id
_pdbx_branch_scheme.auth_seq_num
_pdbx_branch_scheme.hetero
F 6 NAG 1 F NAG 1 A NAG 653 n
F 6 NAG 2 F NAG 2 A NAG 654 n
F 6 BMA 3 F BMA 3 A BMA 655 n
F 6 MAN 4 F MAN 4 A MAN 656 n
#
loop_
_pdbx_nonpoly_scheme.asym_id
_pdbx_nonpoly_scheme.entity_id
_pdbx_nonpoly_scheme.mon_id
_pdbx_nonpoly_scheme.ndb_seq_num
_pdbx_nonpoly_scheme.pdb_seq_num
_pdbx_nonpoly_scheme.auth_seq_num
_pdbx_nonpoly_scheme.pdb_mon_id
_pdbx_nonpoly_scheme.auth_mon_id
_pdbx_nonpoly_scheme.pdb_strand_id
_pdbx_nonpoly_scheme.pdb_ins_code
G 7 NAG 1 701 651 NAG NAG A .
H 7 NAG 1 702 652 NAG NAG A .
I 7 NAG 1 707 657 NAG NAG A .
J 7 NAG 1 708 658 NAG NAG A .
K 7 NAG 1 709 659 NAG NAG A .
#
_software.citation_id ?
_software.classification refinement
_software.compiler_name ?
_software.compiler_version ?
_software.contact_author ?
_software.contact_author_email ?
_software.date ?
_software.description ?
_software.dependencies ?
_software.hardware ?
_software.language ?
_software.location ?
_software.mods ?
_software.name PHENIX
_software.os ?
_software.os_version ?
_software.type ?
_software.version 1.13rc2_2986:
_software.pdbx_ordinal 1
#
_cell.angle_alpha 90.00
_cell.angle_alpha_esd ?
_cell.angle_beta 90.00
_cell.angle_beta_esd ?
_cell.angle_gamma 90.00
_cell.angle_gamma_esd ?
_cell.entry_id 6OGE
_cell.details ?
_cell.formula_units_Z ?
_cell.length_a 1
_cell.length_a_esd ?
_cell.length_b 1
_cell.length_b_esd ?
_cell.length_c 1
_cell.length_c_esd ?
_cell.volume ?
_cell.volume_esd ?
_cell.Z_PDB 1
_cell.reciprocal_angle_alpha ?
_cell.reciprocal_angle_beta ?
_cell.reciprocal_angle_gamma ?
_cell.reciprocal_angle_alpha_esd ?
_cell.reciprocal_angle_beta_esd ?
_cell.reciprocal_angle_gamma_esd ?
_cell.reciprocal_length_a ?
_cell.reciprocal_length_b ?
_cell.reciprocal_length_c ?
_cell.reciprocal_length_a_esd ?
_cell.reciprocal_length_b_esd ?
_cell.reciprocal_length_c_esd ?
_cell.pdbx_unique_axis ?
#
_symmetry.entry_id 6OGE
_symmetry.cell_setting ?
_symmetry.Int_Tables_number 1
_symmetry.space_group_name_Hall ?
_symmetry.space_group_name_H-M 'P 1'
_symmetry.pdbx_full_space_group_name_H-M ?
#
_exptl.absorpt_coefficient_mu ?
_exptl.absorpt_correction_T_max ?
_exptl.absorpt_correction_T_min ?
_exptl.absorpt_correction_type ?
_exptl.absorpt_process_details ?
_exptl.entry_id 6OGE
_exptl.crystals_number ?
_exptl.details ?
_exptl.method 'ELECTRON MICROSCOPY'
_exptl.method_details ?
#
_refine.pdbx_refine_id 'ELECTRON MICROSCOPY'
_refine.entry_id 6OGE
_refine.pdbx_diffrn_id ?
_refine.pdbx_TLS_residual_ADP_flag ?
_refine.ls_number_reflns_obs ?
_refine.ls_number_reflns_all ?
_refine.pdbx_ls_sigma_I ?
_refine.pdbx_ls_sigma_F ?
_refine.pdbx_data_cutoff_high_absF ?
_refine.pdbx_data_cutoff_low_absF ?
_refine.pdbx_data_cutoff_high_rms_absF ?
_refine.ls_d_res_low ?
_refine.ls_d_res_high .
_refine.ls_percent_reflns_obs ?
_refine.ls_R_factor_obs ?
_refine.ls_R_factor_all ?
_refine.ls_R_factor_R_work ?
_refine.ls_R_factor_R_free ?
_refine.ls_R_factor_R_free_error ?
_refine.ls_R_factor_R_free_error_details ?
_refine.ls_percent_reflns_R_free ?
_refine.ls_number_reflns_R_free ?
_refine.ls_number_parameters ?
_refine.ls_number_restraints ?
_refine.occupancy_min ?
_refine.occupancy_max ?
_refine.correlation_coeff_Fo_to_Fc ?
_refine.correlation_coeff_Fo_to_Fc_free ?
_refine.B_iso_mean ?
_refine.aniso_B[1][1] ?
_refine.aniso_B[2][2] ?
_refine.aniso_B[3][3] ?
_refine.aniso_B[1][2] ?
_refine.aniso_B[1][3] ?
_refine.aniso_B[2][3] ?
_refine.solvent_model_details ?
_refine.solvent_model_param_ksol ?
_refine.solvent_model_param_bsol ?
_refine.pdbx_solvent_vdw_probe_radii ?
_refine.pdbx_solvent_ion_probe_radii ?
_refine.pdbx_solvent_shrinkage_radii ?
_refine.pdbx_ls_cross_valid_method ?
_refine.details ?
_refine.pdbx_starting_model ?
_refine.pdbx_method_to_determine_struct ?
_refine.pdbx_isotropic_thermal_model ?
_refine.pdbx_stereochemistry_target_values ?
_refine.pdbx_stereochem_target_val_spec_case ?
_refine.pdbx_R_Free_selection_details ?
_refine.pdbx_overall_ESU_R ?
_refine.pdbx_overall_ESU_R_Free ?
_refine.overall_SU_ML ?
_refine.pdbx_overall_phase_error ?
_refine.overall_SU_B ?
_refine.overall_SU_R_Cruickshank_DPI ?
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI ?
_refine.pdbx_overall_SU_R_Blow_DPI ?
_refine.pdbx_overall_SU_R_free_Blow_DPI ?
#
loop_
_refine_ls_restr.pdbx_refine_id
_refine_ls_restr.criterion
_refine_ls_restr.dev_ideal
_refine_ls_restr.dev_ideal_target
_refine_ls_restr.number
_refine_ls_restr.rejects
_refine_ls_restr.type
_refine_ls_restr.weight
_refine_ls_restr.pdbx_restraint_function
'ELECTRON MICROSCOPY' ? 0.008 ? 11809 ? f_bond_d ? ?
'ELECTRON MICROSCOPY' ? 1.174 ? 16110 ? f_angle_d ? ?
'ELECTRON MICROSCOPY' ? 7.081 ? 7014 ? f_dihedral_angle_d ? ?
'ELECTRON MICROSCOPY' ? 0.057 ? 1810 ? f_chiral_restr ? ?
'ELECTRON MICROSCOPY' ? 0.009 ? 2080 ? f_plane_restr ? ?
#
_struct.entry_id 6OGE
_struct.title 'Cryo-EM structure of Her2 extracellular domain-Trastuzumab Fab-Pertuzumab Fab complex'
_struct.pdbx_model_details ?
_struct.pdbx_formula_weight ?
_struct.pdbx_formula_weight_method ?
_struct.pdbx_model_type_details ?
_struct.pdbx_CASP_flag N
#
_struct_keywords.entry_id 6OGE
_struct_keywords.text 'Her2 extracellular domain, Trastuzumab, Pertuzumab, transferase-immune system complex'
_struct_keywords.pdbx_keywords 'transferase/immune system'
#
loop_
_struct_asym.id
_struct_asym.pdbx_blank_PDB_chainid_flag
_struct_asym.pdbx_modified
_struct_asym.entity_id
_struct_asym.details
A N N 1 ?
B N N 2 ?
C N N 3 ?
D N N 4 ?
E N N 5 ?
F N N 6 ?
G N N 7 ?
H N N 7 ?
I N N 7 ?
J N N 7 ?
K N N 7 ?
#
loop_
_struct_ref.id
_struct_ref.db_name
_struct_ref.db_code
_struct_ref.pdbx_db_accession
_struct_ref.pdbx_db_isoform
_struct_ref.entity_id
_struct_ref.pdbx_seq_one_letter_code
_struct_ref.pdbx_align_begin
1 UNP ERBB2_HUMAN P04626 ? 1
;TQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIV
RGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALT
LIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSG
ICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVC
YGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDL
SVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPED
ECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEAD
QCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPA
;
23
2 PDB 6OGE 6OGE ? 2 ? 1
3 UNP IGKC_HUMAN P01834 ? 2
;RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYE
KHKVYACEVTHQGLSSPVTKSFNRGEC
;
1
4 PDB 6OGE 6OGE ? 3 ? 1
5 UNP IGG1_HUMAN P0DOX5 ? 3
;WGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVV
TVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC
;
109
6 PDB 6OGE 6OGE ? 4 ? 1
7 UNP IGKC_HUMAN P01834 ? 4
;RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYE
KHKVYACEVTHQGLSSPVTKSFNRGEC
;
1
8 PDB 6OGE 6OGE ? 5 ? 1
9 UNP Q6GMX6_HUMAN Q6GMX6 ? 5
;YWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSV
VTVPSSSLGTQTYICNVNHKPSNTKVDKKVEP
;
124
#
loop_
_struct_ref_seq.align_id
_struct_ref_seq.ref_id
_struct_ref_seq.pdbx_PDB_id_code
_struct_ref_seq.pdbx_strand_id
_struct_ref_seq.seq_align_beg
_struct_ref_seq.pdbx_seq_align_beg_ins_code
_struct_ref_seq.seq_align_end
_struct_ref_seq.pdbx_seq_align_end_ins_code
_struct_ref_seq.pdbx_db_accession
_struct_ref_seq.db_align_beg
_struct_ref_seq.pdbx_db_align_beg_ins_code
_struct_ref_seq.db_align_end
_struct_ref_seq.pdbx_db_align_end_ins_code
_struct_ref_seq.pdbx_auth_seq_align_beg
_struct_ref_seq.pdbx_auth_seq_align_end
1 1 6OGE A 1 ? 622 ? P04626 23 ? 644 ? 23 644
2 2 6OGE B 1 ? 107 ? 6OGE 1 ? 107 ? 1 107
3 3 6OGE B 108 ? 214 ? P01834 1 ? 107 ? 108 214
4 4 6OGE C 1 ? 108 ? 6OGE 1 ? 102 ? 1 102
5 5 6OGE C 109 ? 222 ? P0DOX5 109 ? 222 ? 103 216
6 6 6OGE D 1 ? 107 ? 6OGE 1 ? 107 ? 1 107
7 7 6OGE D 108 ? 214 ? P01834 1 ? 107 ? 108 214
8 8 6OGE E 1 ? 108 ? 6OGE 1 ? 108 ? 1 108
9 9 6OGE E 109 ? 220 ? Q6GMX6 124 ? 235 ? 109 220
#
_pdbx_struct_assembly.id 1
_pdbx_struct_assembly.details author_defined_assembly
_pdbx_struct_assembly.method_details ?
_pdbx_struct_assembly.oligomeric_details pentameric
_pdbx_struct_assembly.oligomeric_count 5
#
_pdbx_struct_assembly_gen.assembly_id 1
_pdbx_struct_assembly_gen.oper_expression 1
_pdbx_struct_assembly_gen.asym_id_list A,B,C,D,E,F,G,H,I,J,K
#
_pdbx_struct_assembly_auth_evidence.id 1
_pdbx_struct_assembly_auth_evidence.assembly_id 1
_pdbx_struct_assembly_auth_evidence.experimental_support 'gel filtration'
_pdbx_struct_assembly_auth_evidence.details ?
#
_pdbx_struct_oper_list.id 1
_pdbx_struct_oper_list.type 'identity operation'
_pdbx_struct_oper_list.name 1_555
_pdbx_struct_oper_list.symmetry_operation x,y,z
_pdbx_struct_oper_list.matrix[1][1] 1.0000000000
_pdbx_struct_oper_list.matrix[1][2] 0.0000000000
_pdbx_struct_oper_list.matrix[1][3] 0.0000000000
_pdbx_struct_oper_list.vector[1] 0.0000000000
_pdbx_struct_oper_list.matrix[2][1] 0.0000000000
_pdbx_struct_oper_list.matrix[2][2] 1.0000000000
_pdbx_struct_oper_list.matrix[2][3] 0.0000000000
_pdbx_struct_oper_list.vector[2] 0.0000000000
_pdbx_struct_oper_list.matrix[3][1] 0.0000000000
_pdbx_struct_oper_list.matrix[3][2] 0.0000000000
_pdbx_struct_oper_list.matrix[3][3] 1.0000000000
_pdbx_struct_oper_list.vector[3] 0.0000000000
#
loop_
_struct_conf.conf_type_id
_struct_conf.id
_struct_conf.pdbx_PDB_helix_id
_struct_conf.beg_label_comp_id
_struct_conf.beg_label_asym_id
_struct_conf.beg_label_seq_id
_struct_conf.pdbx_beg_PDB_ins_code
_struct_conf.end_label_comp_id
_struct_conf.end_label_asym_id
_struct_conf.end_label_seq_id
_struct_conf.pdbx_end_PDB_ins_code
_struct_conf.beg_auth_comp_id
_struct_conf.beg_auth_asym_id
_struct_conf.beg_auth_seq_id
_struct_conf.end_auth_comp_id
_struct_conf.end_auth_asym_id
_struct_conf.end_auth_seq_id
_struct_conf.pdbx_PDB_helix_class
_struct_conf.details
_struct_conf.pdbx_PDB_helix_length
HELX_P HELX_P1 AA1 THR A 19 ? TYR A 28 ? THR A 41 TYR A 50 1 ? 10
HELX_P HELX_P2 AA2 LEU A 49 ? ILE A 55 ? LEU A 71 ILE A 77 5 ? 7
HELX_P HELX_P3 AA3 LEU A 146 ? PHE A 151 ? LEU A 168 PHE A 173 1 ? 6
HELX_P HELX_P4 AA4 LEU A 209 ? CYS A 213 ? LEU A 231 CYS A 235 5 ? 5
HELX_P HELX_P5 AA5 LYS A 226 ? CYS A 230 ? LYS A 248 CYS A 252 5 ? 5
HELX_P HELX_P6 AA6 ALA A 337 ? ALA A 343 ? ALA A 359 ALA A 365 5 ? 7
HELX_P HELX_P7 AA7 GLN A 371 ? GLU A 379 ? GLN A 393 GLU A 401 5 ? 9
HELX_P HELX_P8 AA8 LEU A 400 ? GLN A 404 ? LEU A 422 GLN A 426 5 ? 5
HELX_P HELX_P9 AA9 LEU A 414 ? GLY A 417 ? LEU A 436 GLY A 439 5 ? 4
HELX_P HELX_P10 AB1 PRO A 459 ? PHE A 464 ? PRO A 481 PHE A 486 5 ? 6
HELX_P HELX_P11 AB2 ASP A 480 ? GLU A 485 ? ASP A 502 GLU A 507 1 ? 6
HELX_P HELX_P12 AB3 GLN B 79 ? PHE B 83 ? GLN B 79 PHE B 83 5 ? 5
HELX_P HELX_P13 AB4 GLU B 123 ? GLY B 128 ? GLU B 123 GLY B 128 1 ? 6
HELX_P HELX_P14 AB5 SER B 182 ? GLU B 187 ? SER B 182 GLU B 187 1 ? 6
HELX_P HELX_P15 AB6 THR C 28 ? TYR C 32 ? THR C 28 TYR C 32 5 ? 5
HELX_P HELX_P16 AB7 SER C 193 ? THR C 197 ? SER C 187 THR C 191 5 ? 5
HELX_P HELX_P17 AB8 SER D 121 ? LEU D 125 ? SER D 121 LEU D 125 5 ? 5
HELX_P HELX_P18 AB9 ASN E 28 ? THR E 32 ? ASN E 28 THR E 32 5 ? 5
HELX_P HELX_P19 AC1 ASP E 62 ? LYS E 65 ? ASP E 62 LYS E 65 5 ? 4
#
_struct_conf_type.id HELX_P
_struct_conf_type.criteria ?
_struct_conf_type.reference ?
#
loop_
_struct_conn.id
_struct_conn.conn_type_id
_struct_conn.pdbx_leaving_atom_flag
_struct_conn.pdbx_PDB_id
_struct_conn.ptnr1_label_asym_id
_struct_conn.ptnr1_label_comp_id
_struct_conn.ptnr1_label_seq_id
_struct_conn.ptnr1_label_atom_id
_struct_conn.pdbx_ptnr1_label_alt_id
_struct_conn.pdbx_ptnr1_PDB_ins_code
_struct_conn.pdbx_ptnr1_standard_comp_id
_struct_conn.ptnr1_symmetry
_struct_conn.ptnr2_label_asym_id
_struct_conn.ptnr2_label_comp_id
_struct_conn.ptnr2_label_seq_id
_struct_conn.ptnr2_label_atom_id
_struct_conn.pdbx_ptnr2_label_alt_id
_struct_conn.pdbx_ptnr2_PDB_ins_code
_struct_conn.ptnr1_auth_asym_id
_struct_conn.ptnr1_auth_comp_id
_struct_conn.ptnr1_auth_seq_id
_struct_conn.ptnr2_auth_asym_id
_struct_conn.ptnr2_auth_comp_id
_struct_conn.ptnr2_auth_seq_id
_struct_conn.ptnr2_symmetry
_struct_conn.pdbx_ptnr3_label_atom_id
_struct_conn.pdbx_ptnr3_label_seq_id
_struct_conn.pdbx_ptnr3_label_comp_id
_struct_conn.pdbx_ptnr3_label_asym_id
_struct_conn.pdbx_ptnr3_label_alt_id
_struct_conn.pdbx_ptnr3_PDB_ins_code
_struct_conn.details
_struct_conn.pdbx_dist_value
_struct_conn.pdbx_value_order
_struct_conn.pdbx_role
disulf1 disulf ? ? A CYS 4 SG ? ? ? 1_555 A CYS 31 SG ? ? A CYS 26 A CYS 53 1_555 ? ? ? ? ? ? ? 2.026 ? ?
disulf2 disulf ? ? A CYS 140 SG ? ? ? 1_555 A CYS 170 SG ? ? A CYS 162 A CYS 192 1_555 ? ? ? ? ? ? ? 2.030 ? ?
disulf3 disulf ? ? A CYS 173 SG ? ? ? 1_555 A CYS 182 SG ? ? A CYS 195 A CYS 204 1_555 ? ? ? ? ? ? ? 2.039 ? ?
disulf4 disulf ? ? A CYS 177 SG ? ? ? 1_555 A CYS 190 SG ? ? A CYS 199 A CYS 212 1_555 ? ? ? ? ? ? ? 2.032 ? ?
disulf5 disulf ? ? A CYS 198 SG ? ? ? 1_555 A CYS 205 SG ? ? A CYS 220 A CYS 227 1_555 ? ? ? ? ? ? ? 2.018 ? ?
disulf6 disulf ? ? A CYS 202 SG ? ? ? 1_555 A CYS 213 SG ? ? A CYS 224 A CYS 235 1_555 ? ? ? ? ? ? ? 2.028 ? ?
disulf7 disulf ? ? A CYS 214 SG ? ? ? 1_555 A CYS 222 SG ? ? A CYS 236 A CYS 244 1_555 ? ? ? ? ? ? ? 2.031 ? ?
disulf8 disulf ? ? A CYS 218 SG ? ? ? 1_555 A CYS 230 SG ? ? A CYS 240 A CYS 252 1_555 ? ? ? ? ? ? ? 2.024 ? ?
disulf9 disulf ? ? A CYS 233 SG ? ? ? 1_555 A CYS 242 SG ? ? A CYS 255 A CYS 264 1_555 ? ? ? ? ? ? ? 2.021 ? ?
disulf10 disulf ? ? A CYS 246 SG ? ? ? 1_555 A CYS 273 SG ? ? A CYS 268 A CYS 295 1_555 ? ? ? ? ? ? ? 2.027 ? ?
disulf11 disulf ? ? A CYS 277 SG ? ? ? 1_555 A CYS 289 SG ? ? A CYS 299 A CYS 311 1_555 ? ? ? ? ? ? ? 2.034 ? ?
disulf12 disulf ? ? A CYS 293 SG ? ? ? 1_555 A CYS 309 SG ? ? A CYS 315 A CYS 331 1_555 ? ? ? ? ? ? ? 2.031 ? ?
disulf13 disulf ? ? A CYS 312 SG ? ? ? 1_555 A CYS 316 SG ? ? A CYS 334 A CYS 338 1_555 ? ? ? ? ? ? ? 2.032 ? ?
disulf14 disulf ? ? A CYS 320 SG ? ? ? 1_555 A CYS 345 SG ? ? A CYS 342 A CYS 367 1_555 ? ? ? ? ? ? ? 2.029 ? ?
disulf15 disulf ? ? A CYS 453 SG ? ? ? 1_555 A CYS 482 SG ? ? A CYS 475 A CYS 504 1_555 ? ? ? ? ? ? ? 2.034 ? ?
disulf16 disulf ? ? A CYS 489 SG ? ? ? 1_555 A CYS 498 SG ? ? A CYS 511 A CYS 520 1_555 ? ? ? ? ? ? ? 2.036 ? ?
disulf17 disulf ? ? A CYS 493 SG ? ? ? 1_555 A CYS 506 SG ? ? A CYS 515 A CYS 528 1_555 ? ? ? ? ? ? ? 2.032 ? ?
disulf18 disulf ? ? A CYS 509 SG ? ? ? 1_555 A CYS 518 SG ? ? A CYS 531 A CYS 540 1_555 ? ? ? ? ? ? ? 2.030 ? ?
disulf19 disulf ? ? A CYS 522 SG ? ? ? 1_555 A CYS 538 SG ? ? A CYS 544 A CYS 560 1_555 ? ? ? ? ? ? ? 2.028 ? ?
disulf20 disulf ? ? A CYS 541 SG ? ? ? 1_555 A CYS 554 SG ? ? A CYS 563 A CYS 576 1_555 ? ? ? ? ? ? ? 2.050 ? ?
disulf21 disulf ? ? A CYS 545 SG ? ? ? 1_555 A CYS 562 SG ? ? A CYS 567 A CYS 584 1_555 ? ? ? ? ? ? ? 2.135 ? ?
disulf22 disulf ? ? A CYS 565 SG ? ? ? 1_555 A CYS 574 SG ? ? A CYS 587 A CYS 596 1_555 ? ? ? ? ? ? ? 2.027 ? ?
disulf23 disulf ? ? A CYS 578 SG ? ? ? 1_555 A CYS 601 SG ? ? A CYS 600 A CYS 623 1_555 ? ? ? ? ? ? ? 2.035 ? ?
disulf24 disulf ? ? A CYS 604 SG ? ? ? 1_555 A CYS 612 SG ? ? A CYS 626 A CYS 634 1_555 ? ? ? ? ? ? ? 2.030 ? ?
disulf25 disulf ? ? A CYS 608 SG ? ? ? 1_555 A CYS 620 SG ? ? A CYS 630 A CYS 642 1_555 ? ? ? ? ? ? ? 2.041 ? ?
disulf26 disulf ? ? B CYS 23 SG ? ? ? 1_555 B CYS 88 SG ? ? B CYS 23 B CYS 88 1_555 ? ? ? ? ? ? ? 2.038 ? ?
disulf27 disulf ? ? B CYS 134 SG ? ? ? 1_555 B CYS 194 SG ? ? B CYS 134 B CYS 194 1_555 ? ? ? ? ? ? ? 2.037 ? ?
disulf28 disulf ? ? B CYS 214 SG ? ? ? 1_555 C CYS 222 SG ? ? B CYS 214 C CYS 216 1_555 ? ? ? ? ? ? ? 2.033 ? ?
disulf29 disulf ? ? C CYS 22 SG ? ? ? 1_555 C CYS 96 SG ? ? C CYS 22 C CYS 92 1_555 ? ? ? ? ? ? ? 2.033 ? ?
disulf30 disulf ? ? C CYS 146 SG ? ? ? 1_555 C CYS 202 SG ? ? C CYS 140 C CYS 196 1_555 ? ? ? ? ? ? ? 2.040 ? ?
disulf31 disulf ? ? D CYS 23 SG ? ? ? 1_555 D CYS 88 SG ? ? D CYS 23 D CYS 88 1_555 ? ? ? ? ? ? ? 2.032 ? ?
disulf32 disulf ? ? D CYS 134 SG ? ? ? 1_555 D CYS 194 SG ? ? D CYS 134 D CYS 194 1_555 ? ? ? ? ? ? ? 2.036 ? ?
disulf33 disulf ? ? E CYS 22 SG ? ? ? 1_555 E CYS 96 SG ? ? E CYS 22 E CYS 96 1_555 ? ? ? ? ? ? ? 2.037 ? ?
disulf34 disulf ? ? E CYS 147 SG ? ? ? 1_555 E CYS 203 SG ? ? E CYS 147 E CYS 203 1_555 ? ? ? ? ? ? ? 2.030 ? ?
covale1 covale one ? A ASN 46 ND2 ? ? ? 1_555 G NAG . C1 ? ? A ASN 68 A NAG 701 1_555 ? ? ? ? ? ? ? 1.440 ? N-Glycosylation
covale2 covale one ? A ASN 165 ND2 ? ? ? 1_555 H NAG . C1 ? ? A ASN 187 A NAG 702 1_555 ? ? ? ? ? ? ? 1.440 ? N-Glycosylation
covale3 covale one ? A ASN 237 ND2 ? ? ? 1_555 F NAG . C1 ? ? A ASN 259 F NAG 1 1_555 ? ? ? ? ? ? ? 1.424 ? N-Glycosylation
covale4 covale one ? A ASN 508 ND2 ? ? ? 1_555 J NAG . C1 ? ? A ASN 530 A NAG 708 1_555 ? ? ? ? ? ? ? 1.436 ? N-Glycosylation
covale5 covale one ? A ASN 549 ND2 ? ? ? 1_555 I NAG . C1 ? ? A ASN 571 A NAG 707 1_555 ? ? ? ? ? ? ? 1.443 ? N-Glycosylation
covale6 covale one ? A ASN 607 ND2 ? ? ? 1_555 K NAG . C1 ? ? A ASN 629 A NAG 709 1_555 ? ? ? ? ? ? ? 1.445 ? N-Glycosylation
covale7 covale both ? F NAG . O4 ? ? ? 1_555 F NAG . C1 ? ? F NAG 1 F NAG 2 1_555 ? ? ? ? ? ? ? 1.443 ? ?
covale8 covale both ? F NAG . O4 ? ? ? 1_555 F BMA . C1 ? ? F NAG 2 F BMA 3 1_555 ? ? ? ? ? ? ? 1.438 ? ?
covale9 covale both ? F BMA . O3 ? ? ? 1_555 F MAN . C1 ? ? F BMA 3 F MAN 4 1_555 ? ? ? ? ? ? ? 1.436 ? ?
#
loop_
_struct_conn_type.id
_struct_conn_type.criteria
_struct_conn_type.reference
disulf ? ?
covale ? ?
#
loop_
_pdbx_modification_feature.ordinal
_pdbx_modification_feature.label_comp_id
_pdbx_modification_feature.label_asym_id
_pdbx_modification_feature.label_seq_id
_pdbx_modification_feature.label_alt_id
_pdbx_modification_feature.modified_residue_label_comp_id
_pdbx_modification_feature.modified_residue_label_asym_id
_pdbx_modification_feature.modified_residue_label_seq_id
_pdbx_modification_feature.modified_residue_label_alt_id
_pdbx_modification_feature.auth_comp_id
_pdbx_modification_feature.auth_asym_id
_pdbx_modification_feature.auth_seq_id
_pdbx_modification_feature.PDB_ins_code
_pdbx_modification_feature.symmetry
_pdbx_modification_feature.modified_residue_auth_comp_id
_pdbx_modification_feature.modified_residue_auth_asym_id
_pdbx_modification_feature.modified_residue_auth_seq_id
_pdbx_modification_feature.modified_residue_PDB_ins_code
_pdbx_modification_feature.modified_residue_symmetry
_pdbx_modification_feature.comp_id_linking_atom
_pdbx_modification_feature.modified_residue_id_linking_atom
_pdbx_modification_feature.modified_residue_id
_pdbx_modification_feature.ref_pcm_id
_pdbx_modification_feature.ref_comp_id
_pdbx_modification_feature.type
_pdbx_modification_feature.category
1 NAG F . ? ASN A 237 ? NAG F 1 ? 1_555 ASN A 259 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate
2 NAG G . ? ASN A 46 ? NAG A 701 ? 1_555 ASN A 68 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate
3 NAG H . ? ASN A 165 ? NAG A 702 ? 1_555 ASN A 187 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate
4 NAG I . ? ASN A 549 ? NAG A 707 ? 1_555 ASN A 571 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate
5 NAG J . ? ASN A 508 ? NAG A 708 ? 1_555 ASN A 530 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate
6 NAG K . ? ASN A 607 ? NAG A 709 ? 1_555 ASN A 629 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate
7 CYS A 4 ? CYS A 31 ? CYS A 26 ? 1_555 CYS A 53 ? 1_555 SG SG . . . None 'Disulfide bridge'
8 CYS A 140 ? CYS A 170 ? CYS A 162 ? 1_555 CYS A 192 ? 1_555 SG SG . . . None 'Disulfide bridge'
9 CYS A 173 ? CYS A 182 ? CYS A 195 ? 1_555 CYS A 204 ? 1_555 SG SG . . . None 'Disulfide bridge'
10 CYS A 177 ? CYS A 190 ? CYS A 199 ? 1_555 CYS A 212 ? 1_555 SG SG . . . None 'Disulfide bridge'
11 CYS A 198 ? CYS A 205 ? CYS A 220 ? 1_555 CYS A 227 ? 1_555 SG SG . . . None 'Disulfide bridge'
12 CYS A 202 ? CYS A 213 ? CYS A 224 ? 1_555 CYS A 235 ? 1_555 SG SG . . . None 'Disulfide bridge'
13 CYS A 214 ? CYS A 222 ? CYS A 236 ? 1_555 CYS A 244 ? 1_555 SG SG . . . None 'Disulfide bridge'
14 CYS A 218 ? CYS A 230 ? CYS A 240 ? 1_555 CYS A 252 ? 1_555 SG SG . . . None 'Disulfide bridge'
15 CYS A 233 ? CYS A 242 ? CYS A 255 ? 1_555 CYS A 264 ? 1_555 SG SG . . . None 'Disulfide bridge'
16 CYS A 246 ? CYS A 273 ? CYS A 268 ? 1_555 CYS A 295 ? 1_555 SG SG . . . None 'Disulfide bridge'
17 CYS A 277 ? CYS A 289 ? CYS A 299 ? 1_555 CYS A 311 ? 1_555 SG SG . . . None 'Disulfide bridge'
18 CYS A 293 ? CYS A 309 ? CYS A 315 ? 1_555 CYS A 331 ? 1_555 SG SG . . . None 'Disulfide bridge'
19 CYS A 312 ? CYS A 316 ? CYS A 334 ? 1_555 CYS A 338 ? 1_555 SG SG . . . None 'Disulfide bridge'
20 CYS A 320 ? CYS A 345 ? CYS A 342 ? 1_555 CYS A 367 ? 1_555 SG SG . . . None 'Disulfide bridge'
21 CYS A 453 ? CYS A 482 ? CYS A 475 ? 1_555 CYS A 504 ? 1_555 SG SG . . . None 'Disulfide bridge'
22 CYS A 489 ? CYS A 498 ? CYS A 511 ? 1_555 CYS A 520 ? 1_555 SG SG . . . None 'Disulfide bridge'
23 CYS A 493 ? CYS A 506 ? CYS A 515 ? 1_555 CYS A 528 ? 1_555 SG SG . . . None 'Disulfide bridge'
24 CYS A 509 ? CYS A 518 ? CYS A 531 ? 1_555 CYS A 540 ? 1_555 SG SG . . . None 'Disulfide bridge'
25 CYS A 522 ? CYS A 538 ? CYS A 544 ? 1_555 CYS A 560 ? 1_555 SG SG . . . None 'Disulfide bridge'
26 CYS A 541 ? CYS A 554 ? CYS A 563 ? 1_555 CYS A 576 ? 1_555 SG SG . . . None 'Disulfide bridge'
27 CYS A 545 ? CYS A 562 ? CYS A 567 ? 1_555 CYS A 584 ? 1_555 SG SG . . . None 'Disulfide bridge'
28 CYS A 565 ? CYS A 574 ? CYS A 587 ? 1_555 CYS A 596 ? 1_555 SG SG . . . None 'Disulfide bridge'
29 CYS A 578 ? CYS A 601 ? CYS A 600 ? 1_555 CYS A 623 ? 1_555 SG SG . . . None 'Disulfide bridge'
30 CYS A 604 ? CYS A 612 ? CYS A 626 ? 1_555 CYS A 634 ? 1_555 SG SG . . . None 'Disulfide bridge'
31 CYS A 608 ? CYS A 620 ? CYS A 630 ? 1_555 CYS A 642 ? 1_555 SG SG . . . None 'Disulfide bridge'
32 CYS B 23 ? CYS B 88 ? CYS B 23 ? 1_555 CYS B 88 ? 1_555 SG SG . . . None 'Disulfide bridge'
33 CYS B 134 ? CYS B 194 ? CYS B 134 ? 1_555 CYS B 194 ? 1_555 SG SG . . . None 'Disulfide bridge'
34 CYS B 214 ? CYS C 222 ? CYS B 214 ? 1_555 CYS C 216 ? 1_555 SG SG . . . None 'Disulfide bridge'
35 CYS C 22 ? CYS C 96 ? CYS C 22 ? 1_555 CYS C 92 ? 1_555 SG SG . . . None 'Disulfide bridge'
36 CYS C 146 ? CYS C 202 ? CYS C 140 ? 1_555 CYS C 196 ? 1_555 SG SG . . . None 'Disulfide bridge'
37 CYS D 23 ? CYS D 88 ? CYS D 23 ? 1_555 CYS D 88 ? 1_555 SG SG . . . None 'Disulfide bridge'
38 CYS D 134 ? CYS D 194 ? CYS D 134 ? 1_555 CYS D 194 ? 1_555 SG SG . . . None 'Disulfide bridge'
39 CYS E 22 ? CYS E 96 ? CYS E 22 ? 1_555 CYS E 96 ? 1_555 SG SG . . . None 'Disulfide bridge'
40 CYS E 147 ? CYS E 203 ? CYS E 147 ? 1_555 CYS E 203 ? 1_555 SG SG . . . None 'Disulfide bridge'
#
loop_
_struct_mon_prot_cis.pdbx_id
_struct_mon_prot_cis.label_comp_id
_struct_mon_prot_cis.label_seq_id
_struct_mon_prot_cis.label_asym_id
_struct_mon_prot_cis.label_alt_id
_struct_mon_prot_cis.pdbx_PDB_ins_code
_struct_mon_prot_cis.auth_comp_id
_struct_mon_prot_cis.auth_seq_id
_struct_mon_prot_cis.auth_asym_id
_struct_mon_prot_cis.pdbx_label_comp_id_2
_struct_mon_prot_cis.pdbx_label_seq_id_2
_struct_mon_prot_cis.pdbx_label_asym_id_2
_struct_mon_prot_cis.pdbx_PDB_ins_code_2
_struct_mon_prot_cis.pdbx_auth_comp_id_2
_struct_mon_prot_cis.pdbx_auth_seq_id_2
_struct_mon_prot_cis.pdbx_auth_asym_id_2
_struct_mon_prot_cis.pdbx_PDB_model_num
_struct_mon_prot_cis.pdbx_omega_angle
1 PRO 571 A . ? PRO 593 A PRO 572 A ? PRO 594 A 1 15.25
2 SER 7 B . ? SER 7 B PRO 8 B ? PRO 8 B 1 0.89
3 TYR 94 B . ? TYR 94 B PRO 95 B ? PRO 95 B 1 -14.07
4 TYR 140 B . ? TYR 140 B PRO 141 B ? PRO 141 B 1 1.74
5 PHE 152 C . ? PHE 146 C PRO 153 C ? PRO 147 C 1 -6.40
6 GLU 154 C . ? GLU 148 C PRO 155 C ? PRO 149 C 1 -14.30
7 SER 7 D . ? SER 7 D PRO 8 D ? PRO 8 D 1 -6.39
8 THR 94 D . ? THR 94 D PRO 95 D ? PRO 95 D 1 1.87
9 TYR 140 D . ? TYR 140 D PRO 141 D ? PRO 141 D 1 -12.47
10 PHE 153 E . ? PHE 153 E PRO 154 E ? PRO 154 E 1 -1.82
#
loop_
_struct_sheet.id
_struct_sheet.type
_struct_sheet.number_strands
_struct_sheet.details
AA1 ? 5 ?
AA2 ? 5 ?
AA3 ? 2 ?
AA4 ? 2 ?
AA5 ? 4 ?
AA6 ? 5 ?
AA7 ? 2 ?
AA8 ? 2 ?
AA9 ? 4 ?
AB1 ? 2 ?
AB2 ? 4 ?
AB3 ? 4 ?
AB4 ? 3 ?
AB5 ? 4 ?
AB6 ? 2 ?
AB7 ? 4 ?
AB8 ? 4 ?
AB9 ? 4 ?
AC1 ? 3 ?
AC2 ? 3 ?
AC3 ? 5 ?
AC4 ? 2 ?
AC5 ? 2 ?
AC6 ? 3 ?
AC7 ? 4 ?
AC8 ? 2 ?
AC9 ? 2 ?
#
loop_
_struct_sheet_order.sheet_id
_struct_sheet_order.range_id_1
_struct_sheet_order.range_id_2
_struct_sheet_order.offset
_struct_sheet_order.sense
AA1 1 2 ? parallel
AA1 2 3 ? parallel
AA1 3 4 ? parallel
AA1 4 5 ? parallel
AA2 1 2 ? parallel
AA2 2 3 ? parallel
AA2 3 4 ? parallel
AA2 4 5 ? parallel
AA3 1 2 ? anti-parallel
AA4 1 2 ? anti-parallel
AA5 1 2 ? parallel
AA5 2 3 ? parallel
AA5 3 4 ? parallel
AA6 1 2 ? parallel
AA6 2 3 ? parallel
AA6 3 4 ? parallel
AA6 4 5 ? parallel
AA7 1 2 ? anti-parallel
AA8 1 2 ? anti-parallel
AA9 1 2 ? anti-parallel
AA9 2 3 ? anti-parallel
AA9 3 4 ? anti-parallel
AB1 1 2 ? parallel
AB2 1 2 ? anti-parallel
AB2 2 3 ? anti-parallel
AB2 3 4 ? anti-parallel
AB3 1 2 ? anti-parallel
AB3 2 3 ? anti-parallel
AB3 3 4 ? anti-parallel
AB4 1 2 ? anti-parallel
AB4 2 3 ? anti-parallel
AB5 1 2 ? anti-parallel
AB5 2 3 ? anti-parallel
AB5 3 4 ? anti-parallel
AB6 1 2 ? parallel
AB7 1 2 ? anti-parallel
AB7 2 3 ? anti-parallel
AB7 3 4 ? anti-parallel
AB8 1 2 ? anti-parallel
AB8 2 3 ? anti-parallel
AB8 3 4 ? anti-parallel
AB9 1 2 ? anti-parallel
AB9 2 3 ? anti-parallel
AB9 3 4 ? anti-parallel
AC1 1 2 ? anti-parallel
AC1 2 3 ? anti-parallel
AC2 1 2 ? anti-parallel
AC2 2 3 ? anti-parallel
AC3 1 2 ? parallel
AC3 2 3 ? anti-parallel
AC3 3 4 ? anti-parallel
AC3 4 5 ? anti-parallel
AC4 1 2 ? anti-parallel
AC5 1 2 ? anti-parallel
AC6 1 2 ? anti-parallel
AC6 2 3 ? anti-parallel
AC7 1 2 ? anti-parallel
AC7 2 3 ? anti-parallel
AC7 3 4 ? anti-parallel
AC8 1 2 ? anti-parallel
AC9 1 2 ? anti-parallel
#
loop_
_struct_sheet_range.sheet_id
_struct_sheet_range.id
_struct_sheet_range.beg_label_comp_id
_struct_sheet_range.beg_label_asym_id
_struct_sheet_range.beg_label_seq_id
_struct_sheet_range.pdbx_beg_PDB_ins_code
_struct_sheet_range.end_label_comp_id
_struct_sheet_range.end_label_asym_id
_struct_sheet_range.end_label_seq_id
_struct_sheet_range.pdbx_end_PDB_ins_code
_struct_sheet_range.beg_auth_comp_id
_struct_sheet_range.beg_auth_asym_id
_struct_sheet_range.beg_auth_seq_id
_struct_sheet_range.end_auth_comp_id
_struct_sheet_range.end_auth_asym_id
_struct_sheet_range.end_auth_seq_id
AA1 1 VAL A 3 ? THR A 5 ? VAL A 25 THR A 27
AA1 2 VAL A 33 ? GLN A 35 ? VAL A 55 GLN A 57
AA1 3 GLU A 57 ? VAL A 58 ? GLU A 79 VAL A 80
AA1 4 ILE A 79 ? VAL A 80 ? ILE A 101 VAL A 102
AA1 5 GLU A 125 ? ILE A 126 ? GLU A 147 ILE A 148
AA2 1 LEU A 38 ? THR A 41 ? LEU A 60 THR A 63
AA2 2 VAL A 62 ? ALA A 65 ? VAL A 84 ALA A 87
AA2 3 LEU A 92 ? LEU A 95 ? LEU A 114 LEU A 117
AA2 4 VAL A 131 ? GLN A 134 ? VAL A 153 GLN A 156
AA2 5 THR A 160 ? ILE A 162 ? THR A 182 ILE A 184
AA3 1 TYR A 267 ? PHE A 269 ? TYR A 289 PHE A 291
AA3 2 SER A 272 ? VAL A 274 ? SER A 294 VAL A 296
AA4 1 ASN A 297 ? VAL A 300 ? ASN A 319 VAL A 322
AA4 2 ARG A 308 ? LYS A 311 ? ARG A 330 LYS A 333
AA5 1 LYS A 347 ? ILE A 348 ? LYS A 369 ILE A 370
AA5 2 GLU A 383 ? ILE A 384 ? GLU A 405 ILE A 406
AA5 3 VAL A 408 ? ILE A 409 ? VAL A 430 ILE A 431
AA5 4 GLU A 438 ? LEU A 439 ? GLU A 460 LEU A 461
AA6 1 LEU A 352 ? PHE A 354 ? LEU A 374 PHE A 376
AA6 2 LEU A 388 ? ILE A 390 ? LEU A 410 ILE A 412
AA6 3 TYR A 419 ? GLN A 424 ? TYR A 441 GLN A 446
AA6 4 LEU A 443 ? HIS A 447 ? LEU A 465 HIS A 469
AA6 5 LEU A 471 ? HIS A 473 ? LEU A 493 HIS A 495
AA7 1 GLU A 531 ? VAL A 533 ? GLU A 553 VAL A 555
AA7 2 CYS A 538 ? PRO A 540 ? CYS A 560 PRO A 562
AA8 1 TYR A 568 ? ASP A 570 ? TYR A 590 ASP A 592
AA8 2 PHE A 573 ? VAL A 575 ? PHE A 595 VAL A 597
AA9 1 MET B 4 ? SER B 7 ? MET B 4 SER B 7
AA9 2 VAL B 19 ? ALA B 25 ? VAL B 19 ALA B 25
AA9 3 THR B 72 ? ILE B 75 ? THR B 72 ILE B 75
AA9 4 GLY B 64 ? SER B 65 ? GLY B 64 SER B 65
AB1 1 SER B 10 ? ALA B 13 ? SER B 10 ALA B 13
AB1 2 LYS B 103 ? ILE B 106 ? LYS B 103 ILE B 106
AB2 1 TYR B 53 ? ARG B 54 ? TYR B 53 ARG B 54
AB2 2 PRO B 44 ? TYR B 49 ? PRO B 44 TYR B 49
AB2 3 VAL B 33 ? GLN B 38 ? VAL B 33 GLN B 38
AB2 4 THR B 85 ? GLN B 90 ? THR B 85 GLN B 90
AB3 1 PHE B 116 ? PHE B 118 ? PHE B 116 PHE B 118
AB3 2 ALA B 130 ? PHE B 139 ? ALA B 130 PHE B 139
AB3 3 TYR B 173 ? LEU B 181 ? TYR B 173 LEU B 181
AB3 4 SER B 159 ? GLN B 160 ? SER B 159 GLN B 160
AB4 1 ALA B 153 ? GLN B 155 ? ALA B 153 GLN B 155
AB4 2 TRP B 148 ? VAL B 150 ? TRP B 148 VAL B 150
AB4 3 TYR B 192 ? CYS B 194 ? TYR B 192 CYS B 194
AB5 1 GLN C 3 ? SER C 7 ? GLN C 3 SER C 7
AB5 2 SER C 21 ? SER C 25 ? SER C 21 SER C 25
AB5 3 THR C 78 ? LEU C 81 ? THR C 77 LEU C 80
AB5 4 LEU C 70 ? ASP C 73 ? LEU C 69 ASP C 72
AB6 1 LEU C 11 ? VAL C 12 ? LEU C 11 VAL C 12
AB6 2 THR C 116 ? VAL C 117 ? THR C 110 VAL C 111
AB7 1 LEU C 45 ? ASP C 50 ? LEU C 45 ASP C 50
AB7 2 THR C 33 ? GLN C 39 ? THR C 33 GLN C 39
AB7 3 VAL C 93 ? ASN C 99 ? VAL C 89 ASN C 95
AB7 4 THR C 113 ? LEU C 114 ? THR C 107 LEU C 108
AB8 1 SER C 126 ? LEU C 130 ? SER C 120 LEU C 124
AB8 2 LEU C 144 ? TYR C 151 ? LEU C 138 TYR C 145
AB8 3 TYR C 182 ? VAL C 188 ? TYR C 176 VAL C 182
AB8 4 VAL C 169 ? THR C 171 ? VAL C 163 THR C 165
AB9 1 SER C 126 ? LEU C 130 ? SER C 120 LEU C 124
AB9 2 LEU C 144 ? TYR C 151 ? LEU C 138 TYR C 145
AB9 3 TYR C 182 ? VAL C 188 ? TYR C 176 VAL C 182
AB9 4 VAL C 175 ? LEU C 176 ? VAL C 169 LEU C 170
AC1 1 THR C 157 ? TRP C 160 ? THR C 151 TRP C 154
AC1 2 ILE C 201 ? HIS C 206 ? ILE C 195 HIS C 200
AC1 3 THR C 211 ? LYS C 216 ? THR C 205 LYS C 210
AC2 1 THR D 5 ? SER D 7 ? THR D 5 SER D 7
AC2 2 THR D 22 ? ARG D 24 ? THR D 22 ARG D 24
AC2 3 ASP D 70 ? PHE D 71 ? ASP D 70 PHE D 71
AC3 1 LEU D 11 ? ALA D 13 ? LEU D 11 ALA D 13
AC3 2 THR D 102 ? ILE D 106 ? THR D 102 ILE D 106
AC3 3 THR D 85 ? GLN D 90 ? THR D 85 GLN D 90
AC3 4 VAL D 33 ? GLN D 38 ? VAL D 33 GLN D 38
AC3 5 LYS D 45 ? LEU D 46 ? LYS D 45 LEU D 46
AC4 1 ILE D 48 ? TYR D 49 ? ILE D 48 TYR D 49
AC4 2 PHE D 53 ? LEU D 54 ? PHE D 53 LEU D 54
AC5 1 PHE D 62 ? SER D 63 ? PHE D 62 SER D 63
AC5 2 THR D 74 ? ILE D 75 ? THR D 74 ILE D 75
AC6 1 SER E 17 ? ALA E 23 ? SER E 17 ALA E 23
AC6 2 THR E 78 ? ASN E 84 ? THR E 78 ASN E 84
AC6 3 THR E 69 ? ASP E 73 ? THR E 69 ASP E 73
AC7 1 ARG E 59 ? TYR E 60 ? ARG E 59 TYR E 60
AC7 2 LEU E 45 ? ILE E 51 ? LEU E 45 ILE E 51
AC7 3 ILE E 34 ? GLN E 39 ? ILE E 34 GLN E 39
AC7 4 CYS E 96 ? ARG E 98 ? CYS E 96 ARG E 98
AC8 1 ALA E 92 ? VAL E 93 ? ALA E 92 VAL E 93
AC8 2 LEU E 115 ? VAL E 116 ? LEU E 115 VAL E 116
AC9 1 VAL E 149 ? TYR E 152 ? VAL E 149 TYR E 152
AC9 2 TYR E 183 ? LEU E 185 ? TYR E 183 LEU E 185
#
loop_
_pdbx_struct_sheet_hbond.sheet_id
_pdbx_struct_sheet_hbond.range_id_1
_pdbx_struct_sheet_hbond.range_id_2
_pdbx_struct_sheet_hbond.range_1_label_atom_id
_pdbx_struct_sheet_hbond.range_1_label_comp_id
_pdbx_struct_sheet_hbond.range_1_label_asym_id
_pdbx_struct_sheet_hbond.range_1_label_seq_id
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code
_pdbx_struct_sheet_hbond.range_1_auth_atom_id
_pdbx_struct_sheet_hbond.range_1_auth_comp_id
_pdbx_struct_sheet_hbond.range_1_auth_asym_id
_pdbx_struct_sheet_hbond.range_1_auth_seq_id
_pdbx_struct_sheet_hbond.range_2_label_atom_id
_pdbx_struct_sheet_hbond.range_2_label_comp_id
_pdbx_struct_sheet_hbond.range_2_label_asym_id
_pdbx_struct_sheet_hbond.range_2_label_seq_id
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code
_pdbx_struct_sheet_hbond.range_2_auth_atom_id
_pdbx_struct_sheet_hbond.range_2_auth_comp_id
_pdbx_struct_sheet_hbond.range_2_auth_asym_id
_pdbx_struct_sheet_hbond.range_2_auth_seq_id
AA1 1 2 N CYS A 4 ? N CYS A 26 O GLN A 35 ? O GLN A 57
AA1 2 3 N VAL A 34 ? N VAL A 56 O GLU A 57 ? O GLU A 79
AA1 3 4 N VAL A 58 ? N VAL A 80 O ILE A 79 ? O ILE A 101
AA1 4 5 N VAL A 80 ? N VAL A 102 O GLU A 125 ? O GLU A 147
AA2 1 2 N LEU A 38 ? N LEU A 60 O LEU A 63 ? O LEU A 85
AA2 2 3 N ILE A 64 ? N ILE A 86 O ALA A 93 ? O ALA A 115
AA2 3 4 N LEU A 92 ? N LEU A 114 O LEU A 132 ? O LEU A 154
AA2 4 5 N ILE A 133 ? N ILE A 155 O LEU A 161 ? O LEU A 183
AA3 1 2 N TYR A 267 ? N TYR A 289 O VAL A 274 ? O VAL A 296
AA4 1 2 N GLN A 298 ? N GLN A 320 O GLU A 310 ? O GLU A 332
AA5 1 2 N ILE A 348 ? N ILE A 370 O GLU A 383 ? O GLU A 405
AA5 2 3 N ILE A 384 ? N ILE A 406 O VAL A 408 ? O VAL A 430
AA5 3 4 N ILE A 409 ? N ILE A 431 O GLU A 438 ? O GLU A 460
AA6 1 2 N LEU A 352 ? N LEU A 374 O TYR A 389 ? O TYR A 411
AA6 2 3 N LEU A 388 ? N LEU A 410 O THR A 422 ? O THR A 444
AA6 3 4 N LEU A 423 ? N LEU A 445 O LEU A 445 ? O LEU A 467
AA6 4 5 N ILE A 446 ? N ILE A 468 O LEU A 472 ? O LEU A 494
AA7 1 2 N TYR A 532 ? N TYR A 554 O LEU A 539 ? O LEU A 561
AA8 1 2 N ASP A 570 ? N ASP A 592 O PHE A 573 ? O PHE A 595
AA9 1 2 N THR B 5 ? N THR B 5 O LYS B 24 ? O LYS B 24
AA9 2 3 N VAL B 19 ? N VAL B 19 O ILE B 75 ? O ILE B 75
AA9 3 4 O THR B 72 ? O THR B 72 N SER B 65 ? N SER B 65
AB1 1 2 N LEU B 11 ? N LEU B 11 O GLU B 105 ? O GLU B 105
AB2 1 2 O TYR B 53 ? O TYR B 53 N TYR B 49 ? N TYR B 49
AB2 2 3 O LEU B 47 ? O LEU B 47 N TRP B 35 ? N TRP B 35
AB2 3 4 N ALA B 34 ? N ALA B 34 O GLN B 89 ? O GLN B 89
AB3 1 2 N PHE B 116 ? N PHE B 116 O LEU B 135 ? O LEU B 135
AB3 2 3 N CYS B 134 ? N CYS B 134 O SER B 177 ? O SER B 177
AB3 3 4 O THR B 178 ? O THR B 178 N GLN B 160 ? N GLN B 160
AB4 1 2 O ALA B 153 ? O ALA B 153 N VAL B 150 ? N VAL B 150
AB4 2 3 N LYS B 149 ? N LYS B 149 O ALA B 193 ? O ALA B 193
AB5 1 2 N VAL C 5 ? N VAL C 5 O ALA C 23 ? O ALA C 23
AB5 2 3 N CYS C 22 ? N CYS C 22 O LEU C 79 ? O LEU C 78
AB5 3 4 O TYR C 80 ? O TYR C 79 N SER C 71 ? N SER C 70
AB6 1 2 N VAL C 12 ? N VAL C 12 O THR C 116 ? O THR C 110
AB7 1 2 O GLU C 46 ? O GLU C 46 N ARG C 38 ? N ARG C 38
AB7 2 3 N ASP C 35 ? N ASP C 35 O ALA C 97 ? O ALA C 93
AB7 3 4 N TYR C 94 ? N TYR C 90 O THR C 113 ? O THR C 107
AB8 1 2 N SER C 126 ? N SER C 120 O LYS C 149 ? O LYS C 143
AB8 2 3 N VAL C 148 ? N VAL C 142 O LEU C 184 ? O LEU C 178
AB8 3 4 O VAL C 187 ? O VAL C 181 N HIS C 170 ? N HIS C 164
AB9 1 2 N SER C 126 ? N SER C 120 O LYS C 149 ? O LYS C 143
AB9 2 3 N VAL C 148 ? N VAL C 142 O LEU C 184 ? O LEU C 178
AB9 3 4 O SER C 183 ? O SER C 177 N VAL C 175 ? N VAL C 169
AC1 1 2 N SER C 159 ? N SER C 153 O ASN C 203 ? O ASN C 197
AC1 2 3 N CYS C 202 ? N CYS C 196 O LYS C 215 ? O LYS C 209
AC2 1 2 N THR D 5 ? N THR D 5 O ARG D 24 ? O ARG D 24
AC2 2 3 N CYS D 23 ? N CYS D 23 O PHE D 71 ? O PHE D 71
AC3 1 2 N LEU D 11 ? N LEU D 11 O GLU D 105 ? O GLU D 105
AC3 2 3 O THR D 102 ? O THR D 102 N TYR D 86 ? N TYR D 86
AC3 3 4 O GLN D 89 ? O GLN D 89 N ALA D 34 ? N ALA D 34
AC3 4 5 N GLN D 37 ? N GLN D 37 O LYS D 45 ? O LYS D 45
AC4 1 2 N TYR D 49 ? N TYR D 49 O PHE D 53 ? O PHE D 53
AC5 1 2 N SER D 63 ? N SER D 63 O THR D 74 ? O THR D 74
AC6 1 2 N LEU E 18 ? N LEU E 18 O MET E 83 ? O MET E 83
AC6 2 3 O TYR E 80 ? O TYR E 80 N SER E 71 ? N SER E 71
AC7 1 2 O ARG E 59 ? O ARG E 59 N ARG E 50 ? N ARG E 50
AC7 2 3 O VAL E 48 ? O VAL E 48 N TRP E 36 ? N TRP E 36
AC7 3 4 N HIS E 35 ? N HIS E 35 O SER E 97 ? O SER E 97
AC8 1 2 N ALA E 92 ? N ALA E 92 O VAL E 116 ? O VAL E 116
AC9 1 2 N TYR E 152 ? N TYR E 152 O TYR E 183 ? O TYR E 183
#
_pdbx_entry_details.entry_id 6OGE
_pdbx_entry_details.compound_details ?
_pdbx_entry_details.source_details ?
_pdbx_entry_details.nonpolymer_details ?
_pdbx_entry_details.sequence_details ?
_pdbx_entry_details.has_ligand_of_interest ?
_pdbx_entry_details.has_protein_modification Y
#
loop_
_pdbx_validate_rmsd_bond.id
_pdbx_validate_rmsd_bond.PDB_model_num
_pdbx_validate_rmsd_bond.auth_atom_id_1
_pdbx_validate_rmsd_bond.auth_asym_id_1
_pdbx_validate_rmsd_bond.auth_comp_id_1
_pdbx_validate_rmsd_bond.auth_seq_id_1
_pdbx_validate_rmsd_bond.PDB_ins_code_1
_pdbx_validate_rmsd_bond.label_alt_id_1
_pdbx_validate_rmsd_bond.auth_atom_id_2
_pdbx_validate_rmsd_bond.auth_asym_id_2
_pdbx_validate_rmsd_bond.auth_comp_id_2
_pdbx_validate_rmsd_bond.auth_seq_id_2
_pdbx_validate_rmsd_bond.PDB_ins_code_2
_pdbx_validate_rmsd_bond.label_alt_id_2
_pdbx_validate_rmsd_bond.bond_value
_pdbx_validate_rmsd_bond.bond_target_value
_pdbx_validate_rmsd_bond.bond_deviation
_pdbx_validate_rmsd_bond.bond_standard_deviation
_pdbx_validate_rmsd_bond.linker_flag
1 1 CB A CYS 567 ? ? SG A CYS 567 ? ? 1.927 1.818 0.109 0.017 N
2 1 CB A CYS 584 ? ? SG A CYS 584 ? ? 2.042 1.818 0.224 0.017 N
#
loop_
_pdbx_validate_rmsd_angle.id
_pdbx_validate_rmsd_angle.PDB_model_num
_pdbx_validate_rmsd_angle.auth_atom_id_1
_pdbx_validate_rmsd_angle.auth_asym_id_1
_pdbx_validate_rmsd_angle.auth_comp_id_1
_pdbx_validate_rmsd_angle.auth_seq_id_1
_pdbx_validate_rmsd_angle.PDB_ins_code_1
_pdbx_validate_rmsd_angle.label_alt_id_1
_pdbx_validate_rmsd_angle.auth_atom_id_2
_pdbx_validate_rmsd_angle.auth_asym_id_2
_pdbx_validate_rmsd_angle.auth_comp_id_2
_pdbx_validate_rmsd_angle.auth_seq_id_2
_pdbx_validate_rmsd_angle.PDB_ins_code_2
_pdbx_validate_rmsd_angle.label_alt_id_2
_pdbx_validate_rmsd_angle.auth_atom_id_3
_pdbx_validate_rmsd_angle.auth_asym_id_3
_pdbx_validate_rmsd_angle.auth_comp_id_3
_pdbx_validate_rmsd_angle.auth_seq_id_3
_pdbx_validate_rmsd_angle.PDB_ins_code_3
_pdbx_validate_rmsd_angle.label_alt_id_3
_pdbx_validate_rmsd_angle.angle_value
_pdbx_validate_rmsd_angle.angle_target_value
_pdbx_validate_rmsd_angle.angle_deviation
_pdbx_validate_rmsd_angle.angle_standard_deviation
_pdbx_validate_rmsd_angle.linker_flag
1 1 CA A CYS 584 ? ? CB A CYS 584 ? ? SG A CYS 584 ? ? 141.55 114.20 27.35 1.10 N
2 1 CA D LEU 54 ? ? CB D LEU 54 ? ? CG D LEU 54 ? ? 129.36 115.30 14.06 2.30 N
#
loop_
_pdbx_validate_torsion.id
_pdbx_validate_torsion.PDB_model_num
_pdbx_validate_torsion.auth_comp_id
_pdbx_validate_torsion.auth_asym_id
_pdbx_validate_torsion.auth_seq_id
_pdbx_validate_torsion.PDB_ins_code
_pdbx_validate_torsion.label_alt_id
_pdbx_validate_torsion.phi
_pdbx_validate_torsion.psi
1 1 MET A 31 ? ? -141.53 53.39
2 1 LYS A 32 ? ? -55.70 108.25
3 1 PRO A 95 ? ? -91.11 58.74
4 1 ASP A 110 ? ? 54.54 19.64
5 1 LEU A 142 ? ? -103.76 40.69
6 1 GLN A 160 ? ? -104.49 40.41
7 1 ALA A 180 ? ? -96.88 56.80
8 1 ARG A 217 ? ? -133.67 -38.39
9 1 THR A 276 ? ? 68.31 -8.39
10 1 PRO A 300 ? ? -69.24 -176.39
11 1 ASN A 302 ? ? -98.42 38.51
12 1 GLU A 348 ? ? 71.78 -12.24
13 1 HIS A 349 ? ? -140.67 -16.76
14 1 LEU A 455 ? ? -100.45 69.62
15 1 PHE A 476 ? ? 73.69 -5.47
16 1 PRO A 489 ? ? -84.30 45.62
17 1 HIS A 490 ? ? -131.79 -35.47
18 1 GLN A 548 ? ? -131.12 -33.53
19 1 PRO A 565 ? ? -64.57 70.04
20 1 GLN A 568 ? ? -58.00 105.43
21 1 ASP A 582 ? ? -148.11 30.15
22 1 VAL A 585 ? ? -132.81 -54.99
23 1 ALA A 586 ? ? -151.89 -157.96
24 1 ASP A 607 ? ? 66.65 -22.51
25 1 PRO A 612 ? ? -68.92 85.92
26 1 TRP A 614 ? ? 38.60 57.48
27 1 PRO A 625 ? ? -69.08 -174.68
28 1 THR A 631 ? ? 72.77 -11.46
29 1 CYS A 634 ? ? 60.18 69.83
30 1 ASP A 636 ? ? 72.75 -12.55
31 1 PRO B 8 ? ? -84.20 -159.46
32 1 SER B 30 ? ? -56.17 -3.80
33 1 ALA B 51 ? ? 59.11 18.09
34 1 SER B 52 ? ? -141.04 -15.32
35 1 ASN B 138 ? ? 60.55 67.11
36 1 TYR B 140 ? ? -171.64 143.25
37 1 PRO B 141 ? ? -83.01 -155.33
38 1 ASP B 151 ? ? 69.55 -33.12
39 1 ASN B 152 ? ? -153.39 -20.04
40 1 GLU B 187 ? ? -91.70 49.83
41 1 LYS B 188 ? ? -132.21 -36.44
42 1 VAL C 48 ? ? -107.42 -65.65
43 1 PRO C 52 A ? -89.23 42.30
44 1 ASN C 53 ? ? -131.65 -38.11
45 1 ALA C 84 ? ? 56.06 15.42
46 1 PRO C 98 ? ? -84.56 42.13
47 1 SER C 99 ? ? -116.08 -79.97
48 1 PHE C 99 A ? -151.27 2.51
49 1 ASP C 144 ? ? 60.40 61.24
50 1 PRO C 147 ? ? -86.73 -158.04
51 1 GLN D 27 ? ? -146.31 -159.56
52 1 ASN D 30 ? ? -90.60 -64.37
53 1 THR D 31 ? ? -133.17 -35.96
54 1 LYS D 42 ? ? -124.48 -166.19
55 1 LEU D 47 ? ? -96.87 -61.88
56 1 ALA D 51 ? ? 62.32 -0.10
57 1 SER D 52 ? ? -142.50 -2.88
58 1 PRO D 113 ? ? -69.93 -173.60
59 1 GLN D 124 ? ? -103.29 43.03
60 1 LYS D 126 ? ? -130.49 -36.47
61 1 ASN D 138 ? ? 75.04 -9.56
62 1 PRO D 141 ? ? -88.08 -158.12
63 1 ASP D 151 ? ? 34.52 43.99
64 1 SER D 168 ? ? -106.24 41.54
65 1 ASP D 170 ? ? -141.66 46.02
66 1 LEU D 181 ? ? -148.08 -159.03
67 1 LYS D 188 ? ? -92.25 -65.73
68 1 PHE D 209 ? ? -79.79 -166.79
69 1 LYS E 43 ? ? -126.47 -168.10
70 1 GLU E 46 ? ? -161.22 115.69
71 1 THR E 117 ? ? -100.44 58.36
72 1 SER E 119 ? ? -162.58 -167.29
73 1 SER E 134 ? ? -160.75 -169.10
74 1 SER E 137 ? ? -104.38 41.43
75 1 PRO E 154 ? ? -77.35 -155.68
76 1 PHE E 173 ? ? -115.78 62.85
77 1 PRO E 174 ? ? -37.14 131.04
78 1 SER E 180 ? ? -94.77 33.87
#
loop_
_pdbx_validate_peptide_omega.id
_pdbx_validate_peptide_omega.PDB_model_num
_pdbx_validate_peptide_omega.auth_comp_id_1
_pdbx_validate_peptide_omega.auth_asym_id_1
_pdbx_validate_peptide_omega.auth_seq_id_1
_pdbx_validate_peptide_omega.PDB_ins_code_1
_pdbx_validate_peptide_omega.label_alt_id_1
_pdbx_validate_peptide_omega.auth_comp_id_2
_pdbx_validate_peptide_omega.auth_asym_id_2
_pdbx_validate_peptide_omega.auth_seq_id_2
_pdbx_validate_peptide_omega.PDB_ins_code_2
_pdbx_validate_peptide_omega.label_alt_id_2
_pdbx_validate_peptide_omega.omega
1 1 HIS A 564 ? ? PRO A 565 ? ? -138.33
2 1 GLU E 155 ? ? PRO E 156 ? ? 148.78
#
_em_3d_fitting.entry_id 6OGE
_em_3d_fitting.id 1
_em_3d_fitting.details ?
_em_3d_fitting.overall_b_value ?
_em_3d_fitting.ref_protocol 'FLEXIBLE FIT'
_em_3d_fitting.ref_space REAL
_em_3d_fitting.target_criteria ?
_em_3d_fitting.method ?
#
_em_3d_reconstruction.entry_id 6OGE
_em_3d_reconstruction.id 1
_em_3d_reconstruction.algorithm ?
_em_3d_reconstruction.details ?
_em_3d_reconstruction.refinement_type ?
_em_3d_reconstruction.image_processing_id 1
_em_3d_reconstruction.num_class_averages ?
_em_3d_reconstruction.num_particles 398409
_em_3d_reconstruction.resolution 4.36
_em_3d_reconstruction.resolution_method 'FSC 0.143 CUT-OFF'
_em_3d_reconstruction.symmetry_type POINT
_em_3d_reconstruction.method ?
_em_3d_reconstruction.nominal_pixel_size ?
_em_3d_reconstruction.actual_pixel_size ?
_em_3d_reconstruction.magnification_calibration ?
_em_3d_reconstruction.citation_id ?
_em_3d_reconstruction.euler_angles_details ?
#
_em_buffer.id 1
_em_buffer.details ?
_em_buffer.pH 7.5
_em_buffer.specimen_id 1
_em_buffer.name ?
#
loop_
_em_entity_assembly.id
_em_entity_assembly.parent_id
_em_entity_assembly.details
_em_entity_assembly.name
_em_entity_assembly.source
_em_entity_assembly.type
_em_entity_assembly.entity_id_list
_em_entity_assembly.synonym
_em_entity_assembly.oligomeric_details
1 0 ? 'Her2 extracellular domain-Trastuzumab Fab-Pertuzumab Fab complex' 'MULTIPLE SOURCES' COMPLEX '1, 2, 3, 4, 5' ? ?
2 1 ? 'Human HER2 extracellular domain' RECOMBINANT COMPLEX 1 ? ?
3 1 ? 'Pertuzumab Fab' RECOMBINANT COMPLEX '2, 3' ? ?
4 1 ? 'Trastuzumab Fab' RECOMBINANT COMPLEX '4, 5' ? ?
#
_em_image_scans.entry_id 6OGE
_em_image_scans.id 1
_em_image_scans.dimension_height ?
_em_image_scans.dimension_width ?
_em_image_scans.frames_per_image 30
_em_image_scans.image_recording_id 1
_em_image_scans.sampling_size ?
_em_image_scans.scanner_model ?
_em_image_scans.used_frames_per_image ?
_em_image_scans.citation_id ?
_em_image_scans.number_digital_images ?
_em_image_scans.od_range ?
_em_image_scans.quant_bit_size ?
_em_image_scans.details ?
#
_em_imaging.id 1
_em_imaging.entry_id 6OGE
_em_imaging.accelerating_voltage 300
_em_imaging.alignment_procedure ?
_em_imaging.c2_aperture_diameter ?
_em_imaging.calibrated_defocus_max ?
_em_imaging.calibrated_defocus_min ?
_em_imaging.calibrated_magnification ?
_em_imaging.cryogen ?
_em_imaging.details ?
_em_imaging.electron_source 'FIELD EMISSION GUN'
_em_imaging.illumination_mode 'FLOOD BEAM'
_em_imaging.microscope_model 'FEI TITAN KRIOS'
_em_imaging.mode 'BRIGHT FIELD'
_em_imaging.nominal_cs 2.7
_em_imaging.nominal_defocus_max -1500
_em_imaging.nominal_defocus_min -3500
_em_imaging.nominal_magnification 130000
_em_imaging.recording_temperature_maximum ?
_em_imaging.recording_temperature_minimum ?
_em_imaging.residual_tilt ?
_em_imaging.specimen_holder_model ?
_em_imaging.specimen_id 1
_em_imaging.citation_id ?
_em_imaging.date ?
_em_imaging.temperature ?
_em_imaging.tilt_angle_min ?
_em_imaging.tilt_angle_max ?
_em_imaging.astigmatism ?
_em_imaging.detector_distance ?
_em_imaging.electron_beam_tilt_params ?
_em_imaging.specimen_holder_type ?
#
_em_sample_support.id 1
_em_sample_support.specimen_id 1
_em_sample_support.details ?
_em_sample_support.grid_material ?
_em_sample_support.grid_mesh_size 300
_em_sample_support.grid_type 'Quantifoil R1.2/1.3'
_em_sample_support.method ?
_em_sample_support.film_material ?
_em_sample_support.citation_id ?
#
_em_vitrification.id 1
_em_vitrification.specimen_id 1
_em_vitrification.chamber_temperature ?
_em_vitrification.cryogen_name ETHANE
_em_vitrification.details ?
_em_vitrification.humidity 100
_em_vitrification.instrument 'FEI VITROBOT MARK IV'
_em_vitrification.entry_id 6OGE
_em_vitrification.citation_id ?
_em_vitrification.method ?
_em_vitrification.temp ?
_em_vitrification.time_resolved_state ?
#
_em_experiment.entry_id 6OGE
_em_experiment.id 1
_em_experiment.aggregation_state PARTICLE
_em_experiment.reconstruction_method 'SINGLE PARTICLE'
_em_experiment.entity_assembly_id 1
#
_em_single_particle_entity.entry_id 6OGE
_em_single_particle_entity.id 1
_em_single_particle_entity.image_processing_id 1
_em_single_particle_entity.point_symmetry C1
#
loop_
_pdbx_unobs_or_zero_occ_residues.id
_pdbx_unobs_or_zero_occ_residues.PDB_model_num
_pdbx_unobs_or_zero_occ_residues.polymer_flag
_pdbx_unobs_or_zero_occ_residues.occupancy_flag
_pdbx_unobs_or_zero_occ_residues.auth_asym_id
_pdbx_unobs_or_zero_occ_residues.auth_comp_id
_pdbx_unobs_or_zero_occ_residues.auth_seq_id
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code
_pdbx_unobs_or_zero_occ_residues.label_asym_id
_pdbx_unobs_or_zero_occ_residues.label_comp_id
_pdbx_unobs_or_zero_occ_residues.label_seq_id
1 1 Y 1 A THR 127 ? A THR 105
2 1 Y 1 A PRO 128 ? A PRO 106
3 1 Y 1 A VAL 129 ? A VAL 107
#
loop_
_chem_comp_atom.comp_id
_chem_comp_atom.atom_id
_chem_comp_atom.type_symbol
_chem_comp_atom.pdbx_aromatic_flag
_chem_comp_atom.pdbx_stereo_config
_chem_comp_atom.pdbx_ordinal
ALA N N N N 1
ALA CA C N S 2
ALA C C N N 3
ALA O O N N 4
ALA CB C N N 5
ALA OXT O N N 6
ALA H H N N 7
ALA H2 H N N 8
ALA HA H N N 9
ALA HB1 H N N 10
ALA HB2 H N N 11
ALA HB3 H N N 12
ALA HXT H N N 13
ARG N N N N 14
ARG CA C N S 15
ARG C C N N 16
ARG O O N N 17
ARG CB C N N 18
ARG CG C N N 19
ARG CD C N N 20
ARG NE N N N 21
ARG CZ C N N 22
ARG NH1 N N N 23
ARG NH2 N N N 24
ARG OXT O N N 25
ARG H H N N 26
ARG H2 H N N 27
ARG HA H N N 28
ARG HB2 H N N 29
ARG HB3 H N N 30
ARG HG2 H N N 31
ARG HG3 H N N 32
ARG HD2 H N N 33
ARG HD3 H N N 34
ARG HE H N N 35
ARG HH11 H N N 36
ARG HH12 H N N 37
ARG HH21 H N N 38
ARG HH22 H N N 39
ARG HXT H N N 40
ASN N N N N 41
ASN CA C N S 42
ASN C C N N 43
ASN O O N N 44
ASN CB C N N 45
ASN CG C N N 46
ASN OD1 O N N 47
ASN ND2 N N N 48
ASN OXT O N N 49
ASN H H N N 50
ASN H2 H N N 51
ASN HA H N N 52
ASN HB2 H N N 53
ASN HB3 H N N 54
ASN HD21 H N N 55
ASN HD22 H N N 56
ASN HXT H N N 57
ASP N N N N 58
ASP CA C N S 59
ASP C C N N 60
ASP O O N N 61
ASP CB C N N 62
ASP CG C N N 63
ASP OD1 O N N 64
ASP OD2 O N N 65
ASP OXT O N N 66
ASP H H N N 67
ASP H2 H N N 68
ASP HA H N N 69
ASP HB2 H N N 70
ASP HB3 H N N 71
ASP HD2 H N N 72
ASP HXT H N N 73
BMA C1 C N R 74
BMA C2 C N S 75
BMA C3 C N S 76
BMA C4 C N S 77
BMA C5 C N R 78
BMA C6 C N N 79
BMA O1 O N N 80
BMA O2 O N N 81
BMA O3 O N N 82
BMA O4 O N N 83
BMA O5 O N N 84
BMA O6 O N N 85
BMA H1 H N N 86
BMA H2 H N N 87
BMA H3 H N N 88
BMA H4 H N N 89
BMA H5 H N N 90
BMA H61 H N N 91
BMA H62 H N N 92
BMA HO1 H N N 93
BMA HO2 H N N 94
BMA HO3 H N N 95
BMA HO4 H N N 96
BMA HO6 H N N 97
CYS N N N N 98
CYS CA C N R 99
CYS C C N N 100
CYS O O N N 101
CYS CB C N N 102
CYS SG S N N 103
CYS OXT O N N 104
CYS H H N N 105
CYS H2 H N N 106
CYS HA H N N 107
CYS HB2 H N N 108
CYS HB3 H N N 109
CYS HG H N N 110
CYS HXT H N N 111
GLN N N N N 112
GLN CA C N S 113
GLN C C N N 114
GLN O O N N 115
GLN CB C N N 116
GLN CG C N N 117
GLN CD C N N 118
GLN OE1 O N N 119
GLN NE2 N N N 120
GLN OXT O N N 121
GLN H H N N 122
GLN H2 H N N 123
GLN HA H N N 124
GLN HB2 H N N 125
GLN HB3 H N N 126
GLN HG2 H N N 127
GLN HG3 H N N 128
GLN HE21 H N N 129
GLN HE22 H N N 130
GLN HXT H N N 131
GLU N N N N 132
GLU CA C N S 133
GLU C C N N 134
GLU O O N N 135
GLU CB C N N 136
GLU CG C N N 137
GLU CD C N N 138
GLU OE1 O N N 139
GLU OE2 O N N 140
GLU OXT O N N 141
GLU H H N N 142
GLU H2 H N N 143
GLU HA H N N 144
GLU HB2 H N N 145
GLU HB3 H N N 146
GLU HG2 H N N 147
GLU HG3 H N N 148
GLU HE2 H N N 149
GLU HXT H N N 150
GLY N N N N 151
GLY CA C N N 152
GLY C C N N 153
GLY O O N N 154
GLY OXT O N N 155
GLY H H N N 156
GLY H2 H N N 157
GLY HA2 H N N 158
GLY HA3 H N N 159
GLY HXT H N N 160
HIS N N N N 161
HIS CA C N S 162
HIS C C N N 163
HIS O O N N 164
HIS CB C N N 165
HIS CG C Y N 166
HIS ND1 N Y N 167
HIS CD2 C Y N 168
HIS CE1 C Y N 169
HIS NE2 N Y N 170
HIS OXT O N N 171
HIS H H N N 172
HIS H2 H N N 173
HIS HA H N N 174
HIS HB2 H N N 175
HIS HB3 H N N 176
HIS HD1 H N N 177
HIS HD2 H N N 178
HIS HE1 H N N 179
HIS HE2 H N N 180
HIS HXT H N N 181
ILE N N N N 182
ILE CA C N S 183
ILE C C N N 184
ILE O O N N 185
ILE CB C N S 186
ILE CG1 C N N 187
ILE CG2 C N N 188
ILE CD1 C N N 189
ILE OXT O N N 190
ILE H H N N 191
ILE H2 H N N 192
ILE HA H N N 193
ILE HB H N N 194
ILE HG12 H N N 195
ILE HG13 H N N 196
ILE HG21 H N N 197
ILE HG22 H N N 198
ILE HG23 H N N 199
ILE HD11 H N N 200
ILE HD12 H N N 201
ILE HD13 H N N 202
ILE HXT H N N 203
LEU N N N N 204
LEU CA C N S 205
LEU C C N N 206
LEU O O N N 207
LEU CB C N N 208
LEU CG C N N 209
LEU CD1 C N N 210
LEU CD2 C N N 211
LEU OXT O N N 212
LEU H H N N 213
LEU H2 H N N 214
LEU HA H N N 215
LEU HB2 H N N 216
LEU HB3 H N N 217
LEU HG H N N 218
LEU HD11 H N N 219
LEU HD12 H N N 220
LEU HD13 H N N 221
LEU HD21 H N N 222
LEU HD22 H N N 223
LEU HD23 H N N 224
LEU HXT H N N 225
LYS N N N N 226
LYS CA C N S 227
LYS C C N N 228
LYS O O N N 229
LYS CB C N N 230
LYS CG C N N 231
LYS CD C N N 232
LYS CE C N N 233
LYS NZ N N N 234
LYS OXT O N N 235
LYS H H N N 236
LYS H2 H N N 237
LYS HA H N N 238
LYS HB2 H N N 239
LYS HB3 H N N 240
LYS HG2 H N N 241
LYS HG3 H N N 242
LYS HD2 H N N 243
LYS HD3 H N N 244
LYS HE2 H N N 245
LYS HE3 H N N 246
LYS HZ1 H N N 247
LYS HZ2 H N N 248
LYS HZ3 H N N 249
LYS HXT H N N 250
MAN C1 C N S 251
MAN C2 C N S 252
MAN C3 C N S 253
MAN C4 C N S 254
MAN C5 C N R 255
MAN C6 C N N 256
MAN O1 O N N 257
MAN O2 O N N 258
MAN O3 O N N 259
MAN O4 O N N 260
MAN O5 O N N 261
MAN O6 O N N 262
MAN H1 H N N 263
MAN H2 H N N 264
MAN H3 H N N 265
MAN H4 H N N 266
MAN H5 H N N 267
MAN H61 H N N 268
MAN H62 H N N 269
MAN HO1 H N N 270
MAN HO2 H N N 271
MAN HO3 H N N 272
MAN HO4 H N N 273
MAN HO6 H N N 274
MET N N N N 275
MET CA C N S 276
MET C C N N 277
MET O O N N 278
MET CB C N N 279
MET CG C N N 280
MET SD S N N 281
MET CE C N N 282
MET OXT O N N 283
MET H H N N 284
MET H2 H N N 285
MET HA H N N 286
MET HB2 H N N 287
MET HB3 H N N 288
MET HG2 H N N 289
MET HG3 H N N 290
MET HE1 H N N 291
MET HE2 H N N 292
MET HE3 H N N 293
MET HXT H N N 294
NAG C1 C N R 295
NAG C2 C N R 296
NAG C3 C N R 297
NAG C4 C N S 298
NAG C5 C N R 299
NAG C6 C N N 300
NAG C7 C N N 301
NAG C8 C N N 302
NAG N2 N N N 303
NAG O1 O N N 304
NAG O3 O N N 305
NAG O4 O N N 306
NAG O5 O N N 307
NAG O6 O N N 308
NAG O7 O N N 309
NAG H1 H N N 310
NAG H2 H N N 311
NAG H3 H N N 312
NAG H4 H N N 313
NAG H5 H N N 314
NAG H61 H N N 315
NAG H62 H N N 316
NAG H81 H N N 317
NAG H82 H N N 318
NAG H83 H N N 319
NAG HN2 H N N 320
NAG HO1 H N N 321
NAG HO3 H N N 322
NAG HO4 H N N 323
NAG HO6 H N N 324
PHE N N N N 325
PHE CA C N S 326
PHE C C N N 327
PHE O O N N 328
PHE CB C N N 329
PHE CG C Y N 330
PHE CD1 C Y N 331
PHE CD2 C Y N 332
PHE CE1 C Y N 333
PHE CE2 C Y N 334
PHE CZ C Y N 335
PHE OXT O N N 336
PHE H H N N 337
PHE H2 H N N 338
PHE HA H N N 339
PHE HB2 H N N 340
PHE HB3 H N N 341
PHE HD1 H N N 342
PHE HD2 H N N 343
PHE HE1 H N N 344
PHE HE2 H N N 345
PHE HZ H N N 346
PHE HXT H N N 347
PRO N N N N 348
PRO CA C N S 349
PRO C C N N 350
PRO O O N N 351
PRO CB C N N 352
PRO CG C N N 353
PRO CD C N N 354
PRO OXT O N N 355
PRO H H N N 356
PRO HA H N N 357
PRO HB2 H N N 358
PRO HB3 H N N 359
PRO HG2 H N N 360
PRO HG3 H N N 361
PRO HD2 H N N 362
PRO HD3 H N N 363
PRO HXT H N N 364
SER N N N N 365
SER CA C N S 366
SER C C N N 367
SER O O N N 368
SER CB C N N 369
SER OG O N N 370
SER OXT O N N 371
SER H H N N 372
SER H2 H N N 373
SER HA H N N 374
SER HB2 H N N 375
SER HB3 H N N 376
SER HG H N N 377
SER HXT H N N 378
THR N N N N 379
THR CA C N S 380
THR C C N N 381
THR O O N N 382
THR CB C N R 383
THR OG1 O N N 384
THR CG2 C N N 385
THR OXT O N N 386
THR H H N N 387
THR H2 H N N 388
THR HA H N N 389
THR HB H N N 390
THR HG1 H N N 391
THR HG21 H N N 392
THR HG22 H N N 393
THR HG23 H N N 394
THR HXT H N N 395
TRP N N N N 396
TRP CA C N S 397
TRP C C N N 398
TRP O O N N 399
TRP CB C N N 400
TRP CG C Y N 401
TRP CD1 C Y N 402
TRP CD2 C Y N 403
TRP NE1 N Y N 404
TRP CE2 C Y N 405
TRP CE3 C Y N 406
TRP CZ2 C Y N 407
TRP CZ3 C Y N 408
TRP CH2 C Y N 409
TRP OXT O N N 410
TRP H H N N 411
TRP H2 H N N 412
TRP HA H N N 413
TRP HB2 H N N 414
TRP HB3 H N N 415
TRP HD1 H N N 416
TRP HE1 H N N 417
TRP HE3 H N N 418
TRP HZ2 H N N 419
TRP HZ3 H N N 420
TRP HH2 H N N 421
TRP HXT H N N 422
TYR N N N N 423
TYR CA C N S 424
TYR C C N N 425
TYR O O N N 426
TYR CB C N N 427
TYR CG C Y N 428
TYR CD1 C Y N 429
TYR CD2 C Y N 430
TYR CE1 C Y N 431
TYR CE2 C Y N 432
TYR CZ C Y N 433
TYR OH O N N 434
TYR OXT O N N 435
TYR H H N N 436
TYR H2 H N N 437
TYR HA H N N 438
TYR HB2 H N N 439
TYR HB3 H N N 440
TYR HD1 H N N 441
TYR HD2 H N N 442
TYR HE1 H N N 443
TYR HE2 H N N 444
TYR HH H N N 445
TYR HXT H N N 446
VAL N N N N 447
VAL CA C N S 448
VAL C C N N 449
VAL O O N N 450
VAL CB C N N 451
VAL CG1 C N N 452
VAL CG2 C N N 453
VAL OXT O N N 454
VAL H H N N 455
VAL H2 H N N 456
VAL HA H N N 457
VAL HB H N N 458
VAL HG11 H N N 459
VAL HG12 H N N 460
VAL HG13 H N N 461
VAL HG21 H N N 462
VAL HG22 H N N 463
VAL HG23 H N N 464
VAL HXT H N N 465
#
loop_
_chem_comp_bond.comp_id
_chem_comp_bond.atom_id_1
_chem_comp_bond.atom_id_2
_chem_comp_bond.value_order
_chem_comp_bond.pdbx_aromatic_flag
_chem_comp_bond.pdbx_stereo_config
_chem_comp_bond.pdbx_ordinal
ALA N CA sing N N 1
ALA N H sing N N 2
ALA N H2 sing N N 3
ALA CA C sing N N 4
ALA CA CB sing N N 5
ALA CA HA sing N N 6
ALA C O doub N N 7
ALA C OXT sing N N 8
ALA CB HB1 sing N N 9
ALA CB HB2 sing N N 10
ALA CB HB3 sing N N 11
ALA OXT HXT sing N N 12
ARG N CA sing N N 13
ARG N H sing N N 14
ARG N H2 sing N N 15
ARG CA C sing N N 16
ARG CA CB sing N N 17
ARG CA HA sing N N 18
ARG C O doub N N 19
ARG C OXT sing N N 20
ARG CB CG sing N N 21
ARG CB HB2 sing N N 22
ARG CB HB3 sing N N 23
ARG CG CD sing N N 24
ARG CG HG2 sing N N 25
ARG CG HG3 sing N N 26
ARG CD NE sing N N 27
ARG CD HD2 sing N N 28
ARG CD HD3 sing N N 29
ARG NE CZ sing N N 30
ARG NE HE sing N N 31
ARG CZ NH1 sing N N 32
ARG CZ NH2 doub N N 33
ARG NH1 HH11 sing N N 34
ARG NH1 HH12 sing N N 35
ARG NH2 HH21 sing N N 36
ARG NH2 HH22 sing N N 37
ARG OXT HXT sing N N 38
ASN N CA sing N N 39
ASN N H sing N N 40
ASN N H2 sing N N 41
ASN CA C sing N N 42
ASN CA CB sing N N 43
ASN CA HA sing N N 44
ASN C O doub N N 45
ASN C OXT sing N N 46
ASN CB CG sing N N 47
ASN CB HB2 sing N N 48
ASN CB HB3 sing N N 49
ASN CG OD1 doub N N 50
ASN CG ND2 sing N N 51
ASN ND2 HD21 sing N N 52
ASN ND2 HD22 sing N N 53
ASN OXT HXT sing N N 54
ASP N CA sing N N 55
ASP N H sing N N 56
ASP N H2 sing N N 57
ASP CA C sing N N 58
ASP CA CB sing N N 59
ASP CA HA sing N N 60
ASP C O doub N N 61
ASP C OXT sing N N 62
ASP CB CG sing N N 63
ASP CB HB2 sing N N 64
ASP CB HB3 sing N N 65
ASP CG OD1 doub N N 66
ASP CG OD2 sing N N 67
ASP OD2 HD2 sing N N 68
ASP OXT HXT sing N N 69
BMA C1 C2 sing N N 70
BMA C1 O1 sing N N 71
BMA C1 O5 sing N N 72
BMA C1 H1 sing N N 73
BMA C2 C3 sing N N 74
BMA C2 O2 sing N N 75
BMA C2 H2 sing N N 76
BMA C3 C4 sing N N 77
BMA C3 O3 sing N N 78
BMA C3 H3 sing N N 79
BMA C4 C5 sing N N 80
BMA C4 O4 sing N N 81
BMA C4 H4 sing N N 82
BMA C5 C6 sing N N 83
BMA C5 O5 sing N N 84
BMA C5 H5 sing N N 85
BMA C6 O6 sing N N 86
BMA C6 H61 sing N N 87
BMA C6 H62 sing N N 88
BMA O1 HO1 sing N N 89
BMA O2 HO2 sing N N 90
BMA O3 HO3 sing N N 91
BMA O4 HO4 sing N N 92
BMA O6 HO6 sing N N 93
CYS N CA sing N N 94
CYS N H sing N N 95
CYS N H2 sing N N 96
CYS CA C sing N N 97
CYS CA CB sing N N 98
CYS CA HA sing N N 99
CYS C O doub N N 100
CYS C OXT sing N N 101
CYS CB SG sing N N 102
CYS CB HB2 sing N N 103
CYS CB HB3 sing N N 104
CYS SG HG sing N N 105
CYS OXT HXT sing N N 106
GLN N CA sing N N 107
GLN N H sing N N 108
GLN N H2 sing N N 109
GLN CA C sing N N 110
GLN CA CB sing N N 111
GLN CA HA sing N N 112
GLN C O doub N N 113
GLN C OXT sing N N 114
GLN CB CG sing N N 115
GLN CB HB2 sing N N 116
GLN CB HB3 sing N N 117
GLN CG CD sing N N 118
GLN CG HG2 sing N N 119
GLN CG HG3 sing N N 120
GLN CD OE1 doub N N 121
GLN CD NE2 sing N N 122
GLN NE2 HE21 sing N N 123
GLN NE2 HE22 sing N N 124
GLN OXT HXT sing N N 125
GLU N CA sing N N 126
GLU N H sing N N 127
GLU N H2 sing N N 128
GLU CA C sing N N 129
GLU CA CB sing N N 130
GLU CA HA sing N N 131
GLU C O doub N N 132
GLU C OXT sing N N 133
GLU CB CG sing N N 134
GLU CB HB2 sing N N 135
GLU CB HB3 sing N N 136
GLU CG CD sing N N 137
GLU CG HG2 sing N N 138
GLU CG HG3 sing N N 139
GLU CD OE1 doub N N 140
GLU CD OE2 sing N N 141
GLU OE2 HE2 sing N N 142
GLU OXT HXT sing N N 143
GLY N CA sing N N 144
GLY N H sing N N 145
GLY N H2 sing N N 146
GLY CA C sing N N 147
GLY CA HA2 sing N N 148
GLY CA HA3 sing N N 149
GLY C O doub N N 150
GLY C OXT sing N N 151
GLY OXT HXT sing N N 152
HIS N CA sing N N 153
HIS N H sing N N 154
HIS N H2 sing N N 155
HIS CA C sing N N 156
HIS CA CB sing N N 157
HIS CA HA sing N N 158
HIS C O doub N N 159
HIS C OXT sing N N 160
HIS CB CG sing N N 161
HIS CB HB2 sing N N 162
HIS CB HB3 sing N N 163
HIS CG ND1 sing Y N 164
HIS CG CD2 doub Y N 165
HIS ND1 CE1 doub Y N 166
HIS ND1 HD1 sing N N 167
HIS CD2 NE2 sing Y N 168
HIS CD2 HD2 sing N N 169
HIS CE1 NE2 sing Y N 170
HIS CE1 HE1 sing N N 171
HIS NE2 HE2 sing N N 172
HIS OXT HXT sing N N 173
ILE N CA sing N N 174
ILE N H sing N N 175
ILE N H2 sing N N 176
ILE CA C sing N N 177
ILE CA CB sing N N 178
ILE CA HA sing N N 179
ILE C O doub N N 180
ILE C OXT sing N N 181
ILE CB CG1 sing N N 182
ILE CB CG2 sing N N 183
ILE CB HB sing N N 184
ILE CG1 CD1 sing N N 185
ILE CG1 HG12 sing N N 186
ILE CG1 HG13 sing N N 187
ILE CG2 HG21 sing N N 188
ILE CG2 HG22 sing N N 189
ILE CG2 HG23 sing N N 190
ILE CD1 HD11 sing N N 191
ILE CD1 HD12 sing N N 192
ILE CD1 HD13 sing N N 193
ILE OXT HXT sing N N 194
LEU N CA sing N N 195
LEU N H sing N N 196
LEU N H2 sing N N 197
LEU CA C sing N N 198
LEU CA CB sing N N 199
LEU CA HA sing N N 200
LEU C O doub N N 201
LEU C OXT sing N N 202
LEU CB CG sing N N 203
LEU CB HB2 sing N N 204
LEU CB HB3 sing N N 205
LEU CG CD1 sing N N 206
LEU CG CD2 sing N N 207
LEU CG HG sing N N 208
LEU CD1 HD11 sing N N 209
LEU CD1 HD12 sing N N 210
LEU CD1 HD13 sing N N 211
LEU CD2 HD21 sing N N 212
LEU CD2 HD22 sing N N 213
LEU CD2 HD23 sing N N 214
LEU OXT HXT sing N N 215
LYS N CA sing N N 216
LYS N H sing N N 217
LYS N H2 sing N N 218
LYS CA C sing N N 219
LYS CA CB sing N N 220
LYS CA HA sing N N 221
LYS C O doub N N 222
LYS C OXT sing N N 223
LYS CB CG sing N N 224
LYS CB HB2 sing N N 225
LYS CB HB3 sing N N 226
LYS CG CD sing N N 227
LYS CG HG2 sing N N 228
LYS CG HG3 sing N N 229
LYS CD CE sing N N 230
LYS CD HD2 sing N N 231
LYS CD HD3 sing N N 232
LYS CE NZ sing N N 233
LYS CE HE2 sing N N 234
LYS CE HE3 sing N N 235
LYS NZ HZ1 sing N N 236
LYS NZ HZ2 sing N N 237
LYS NZ HZ3 sing N N 238
LYS OXT HXT sing N N 239
MAN C1 C2 sing N N 240
MAN C1 O1 sing N N 241
MAN C1 O5 sing N N 242
MAN C1 H1 sing N N 243
MAN C2 C3 sing N N 244
MAN C2 O2 sing N N 245
MAN C2 H2 sing N N 246
MAN C3 C4 sing N N 247
MAN C3 O3 sing N N 248
MAN C3 H3 sing N N 249
MAN C4 C5 sing N N 250
MAN C4 O4 sing N N 251
MAN C4 H4 sing N N 252
MAN C5 C6 sing N N 253
MAN C5 O5 sing N N 254
MAN C5 H5 sing N N 255
MAN C6 O6 sing N N 256
MAN C6 H61 sing N N 257
MAN C6 H62 sing N N 258
MAN O1 HO1 sing N N 259
MAN O2 HO2 sing N N 260
MAN O3 HO3 sing N N 261
MAN O4 HO4 sing N N 262
MAN O6 HO6 sing N N 263
MET N CA sing N N 264
MET N H sing N N 265
MET N H2 sing N N 266
MET CA C sing N N 267
MET CA CB sing N N 268
MET CA HA sing N N 269
MET C O doub N N 270
MET C OXT sing N N 271
MET CB CG sing N N 272
MET CB HB2 sing N N 273
MET CB HB3 sing N N 274
MET CG SD sing N N 275
MET CG HG2 sing N N 276
MET CG HG3 sing N N 277
MET SD CE sing N N 278
MET CE HE1 sing N N 279
MET CE HE2 sing N N 280
MET CE HE3 sing N N 281
MET OXT HXT sing N N 282
NAG C1 C2 sing N N 283
NAG C1 O1 sing N N 284
NAG C1 O5 sing N N 285
NAG C1 H1 sing N N 286
NAG C2 C3 sing N N 287
NAG C2 N2 sing N N 288
NAG C2 H2 sing N N 289
NAG C3 C4 sing N N 290
NAG C3 O3 sing N N 291
NAG C3 H3 sing N N 292
NAG C4 C5 sing N N 293
NAG C4 O4 sing N N 294
NAG C4 H4 sing N N 295
NAG C5 C6 sing N N 296
NAG C5 O5 sing N N 297
NAG C5 H5 sing N N 298
NAG C6 O6 sing N N 299
NAG C6 H61 sing N N 300
NAG C6 H62 sing N N 301
NAG C7 C8 sing N N 302
NAG C7 N2 sing N N 303
NAG C7 O7 doub N N 304
NAG C8 H81 sing N N 305
NAG C8 H82 sing N N 306
NAG C8 H83 sing N N 307
NAG N2 HN2 sing N N 308
NAG O1 HO1 sing N N 309
NAG O3 HO3 sing N N 310
NAG O4 HO4 sing N N 311
NAG O6 HO6 sing N N 312
PHE N CA sing N N 313
PHE N H sing N N 314
PHE N H2 sing N N 315
PHE CA C sing N N 316
PHE CA CB sing N N 317
PHE CA HA sing N N 318
PHE C O doub N N 319
PHE C OXT sing N N 320
PHE CB CG sing N N 321
PHE CB HB2 sing N N 322
PHE CB HB3 sing N N 323
PHE CG CD1 doub Y N 324
PHE CG CD2 sing Y N 325
PHE CD1 CE1 sing Y N 326
PHE CD1 HD1 sing N N 327
PHE CD2 CE2 doub Y N 328
PHE CD2 HD2 sing N N 329
PHE CE1 CZ doub Y N 330
PHE CE1 HE1 sing N N 331
PHE CE2 CZ sing Y N 332
PHE CE2 HE2 sing N N 333
PHE CZ HZ sing N N 334
PHE OXT HXT sing N N 335
PRO N CA sing N N 336
PRO N CD sing N N 337
PRO N H sing N N 338
PRO CA C sing N N 339
PRO CA CB sing N N 340
PRO CA HA sing N N 341
PRO C O doub N N 342
PRO C OXT sing N N 343
PRO CB CG sing N N 344
PRO CB HB2 sing N N 345
PRO CB HB3 sing N N 346
PRO CG CD sing N N 347
PRO CG HG2 sing N N 348
PRO CG HG3 sing N N 349
PRO CD HD2 sing N N 350
PRO CD HD3 sing N N 351
PRO OXT HXT sing N N 352
SER N CA sing N N 353
SER N H sing N N 354
SER N H2 sing N N 355
SER CA C sing N N 356
SER CA CB sing N N 357
SER CA HA sing N N 358
SER C O doub N N 359
SER C OXT sing N N 360
SER CB OG sing N N 361
SER CB HB2 sing N N 362
SER CB HB3 sing N N 363
SER OG HG sing N N 364
SER OXT HXT sing N N 365
THR N CA sing N N 366
THR N H sing N N 367
THR N H2 sing N N 368
THR CA C sing N N 369
THR CA CB sing N N 370
THR CA HA sing N N 371
THR C O doub N N 372
THR C OXT sing N N 373
THR CB OG1 sing N N 374
THR CB CG2 sing N N 375
THR CB HB sing N N 376
THR OG1 HG1 sing N N 377
THR CG2 HG21 sing N N 378
THR CG2 HG22 sing N N 379
THR CG2 HG23 sing N N 380
THR OXT HXT sing N N 381
TRP N CA sing N N 382
TRP N H sing N N 383
TRP N H2 sing N N 384
TRP CA C sing N N 385
TRP CA CB sing N N 386
TRP CA HA sing N N 387
TRP C O doub N N 388
TRP C OXT sing N N 389
TRP CB CG sing N N 390
TRP CB HB2 sing N N 391
TRP CB HB3 sing N N 392
TRP CG CD1 doub Y N 393
TRP CG CD2 sing Y N 394
TRP CD1 NE1 sing Y N 395
TRP CD1 HD1 sing N N 396
TRP CD2 CE2 doub Y N 397
TRP CD2 CE3 sing Y N 398
TRP NE1 CE2 sing Y N 399
TRP NE1 HE1 sing N N 400
TRP CE2 CZ2 sing Y N 401
TRP CE3 CZ3 doub Y N 402
TRP CE3 HE3 sing N N 403
TRP CZ2 CH2 doub Y N 404
TRP CZ2 HZ2 sing N N 405
TRP CZ3 CH2 sing Y N 406
TRP CZ3 HZ3 sing N N 407
TRP CH2 HH2 sing N N 408
TRP OXT HXT sing N N 409
TYR N CA sing N N 410
TYR N H sing N N 411
TYR N H2 sing N N 412
TYR CA C sing N N 413
TYR CA CB sing N N 414
TYR CA HA sing N N 415
TYR C O doub N N 416
TYR C OXT sing N N 417
TYR CB CG sing N N 418
TYR CB HB2 sing N N 419
TYR CB HB3 sing N N 420
TYR CG CD1 doub Y N 421
TYR CG CD2 sing Y N 422
TYR CD1 CE1 sing Y N 423
TYR CD1 HD1 sing N N 424
TYR CD2 CE2 doub Y N 425
TYR CD2 HD2 sing N N 426
TYR CE1 CZ doub Y N 427
TYR CE1 HE1 sing N N 428
TYR CE2 CZ sing Y N 429
TYR CE2 HE2 sing N N 430
TYR CZ OH sing N N 431
TYR OH HH sing N N 432
TYR OXT HXT sing N N 433
VAL N CA sing N N 434
VAL N H sing N N 435
VAL N H2 sing N N 436
VAL CA C sing N N 437
VAL CA CB sing N N 438
VAL CA HA sing N N 439
VAL C O doub N N 440
VAL C OXT sing N N 441
VAL CB CG1 sing N N 442
VAL CB CG2 sing N N 443
VAL CB HB sing N N 444
VAL CG1 HG11 sing N N 445
VAL CG1 HG12 sing N N 446
VAL CG1 HG13 sing N N 447
VAL CG2 HG21 sing N N 448
VAL CG2 HG22 sing N N 449
VAL CG2 HG23 sing N N 450
VAL OXT HXT sing N N 451
#
_em_admin.entry_id 6OGE
_em_admin.current_status REL
_em_admin.deposition_date 2019-04-02
_em_admin.deposition_site RCSB
_em_admin.last_update 2024-11-20
_em_admin.map_release_date 2019-05-15
_em_admin.title 'Cryo-EM structure of Her2 extracellular domain-Trastuzumab Fab-Pertuzumab Fab complex'
#
loop_
_em_buffer_component.buffer_id
_em_buffer_component.id
_em_buffer_component.concentration
_em_buffer_component.concentration_units
_em_buffer_component.formula
_em_buffer_component.name
1 1 20 mM C8H18N2O4S HEPES
1 2 150 mM NaCl 'Sodium Chloride'
#
_em_ctf_correction.id 1
_em_ctf_correction.em_image_processing_id 1
_em_ctf_correction.type 'PHASE FLIPPING AND AMPLITUDE CORRECTION'
_em_ctf_correction.details ?
#
loop_
_em_entity_assembly_naturalsource.id
_em_entity_assembly_naturalsource.entity_assembly_id
_em_entity_assembly_naturalsource.cell
_em_entity_assembly_naturalsource.cellular_location
_em_entity_assembly_naturalsource.ncbi_tax_id
_em_entity_assembly_naturalsource.organ
_em_entity_assembly_naturalsource.organelle
_em_entity_assembly_naturalsource.organism
_em_entity_assembly_naturalsource.strain
_em_entity_assembly_naturalsource.tissue
1 1 ? ? 9606 ? ? 'Homo sapiens' ? ?
2 2 ? ? 9606 ? ? 'Homo sapiens' ? ?
3 3 ? ? 9606 ? ? 'Homo sapiens' ? ?
4 4 ? ? 9606 ? ? 'Homo sapiens' ? ?
#
loop_
_em_entity_assembly_recombinant.id
_em_entity_assembly_recombinant.entity_assembly_id
_em_entity_assembly_recombinant.cell
_em_entity_assembly_recombinant.ncbi_tax_id
_em_entity_assembly_recombinant.organism
_em_entity_assembly_recombinant.plasmid
_em_entity_assembly_recombinant.strain
1 1 ? 9606 'Homo sapiens' ? ?
2 2 ? 9606 'Homo sapiens' ? ?
3 3 ? 10029 'Cricetulus griseus' ? ?
4 4 ? 10029 'Cricetulus griseus' ? ?
#
_em_image_processing.id 1
_em_image_processing.image_recording_id 1
_em_image_processing.details ?
#
_em_image_recording.id 1
_em_image_recording.imaging_id 1
_em_image_recording.avg_electron_dose_per_image 45
_em_image_recording.average_exposure_time 6
_em_image_recording.details ?
_em_image_recording.detector_mode SUPER-RESOLUTION
_em_image_recording.film_or_detector_model 'GATAN K2 SUMMIT (4k x 4k)'
_em_image_recording.num_diffraction_images ?
_em_image_recording.num_grids_imaged ?
_em_image_recording.num_real_images ?
#
_em_imaging_optics.id 1
_em_imaging_optics.imaging_id 1
_em_imaging_optics.chr_aberration_corrector ?
_em_imaging_optics.energyfilter_lower ?
_em_imaging_optics.energyfilter_name ?
_em_imaging_optics.energyfilter_upper ?
_em_imaging_optics.energyfilter_slit_width ?
_em_imaging_optics.phase_plate ?
_em_imaging_optics.sph_aberration_corrector ?
#
_em_particle_selection.id 1
_em_particle_selection.image_processing_id 1
_em_particle_selection.details ?
_em_particle_selection.method ?
_em_particle_selection.num_particles_selected 1032611
_em_particle_selection.reference_model ?
#
loop_
_em_software.id
_em_software.category
_em_software.details
_em_software.name
_em_software.version
_em_software.image_processing_id
_em_software.fitting_id
_em_software.imaging_id
1 'PARTICLE SELECTION' ? cisTEM ? 1 ? ?
2 'IMAGE ACQUISITION' ? SerialEM ? ? ? 1
3 MASKING ? ? ? ? ? ?
4 'CTF CORRECTION' ? CTFFIND ? 1 ? ?
5 'LAYERLINE INDEXING' ? ? ? ? ? ?
6 'DIFFRACTION INDEXING' ? ? ? ? ? ?
7 'MODEL FITTING' ? ? ? ? 1 ?
8 OTHER ? ? ? ? ? ?
9 'INITIAL EULER ASSIGNMENT' ? cisTEM ? 1 ? ?
10 'FINAL EULER ASSIGNMENT' ? ? ? 1 ? ?
11 CLASSIFICATION ? ? ? 1 ? ?
12 RECONSTRUCTION ? cisTEM ? 1 ? ?
13 'MODEL REFINEMENT' ? PHENIX ? ? 1 ?
#
_em_specimen.id 1
_em_specimen.experiment_id 1
_em_specimen.concentration 2.4
_em_specimen.details ?
_em_specimen.embedding_applied NO
_em_specimen.shadowing_applied NO
_em_specimen.staining_applied NO
_em_specimen.vitrification_applied YES
#
loop_
_pdbx_entity_branch_list.entity_id
_pdbx_entity_branch_list.comp_id
_pdbx_entity_branch_list.num
_pdbx_entity_branch_list.hetero
6 NAG 1 n
6 NAG 2 n
6 BMA 3 n
6 MAN 4 n
#
_atom_sites.entry_id 6OGE
_atom_sites.fract_transf_matrix[1][1] 1.000000
_atom_sites.fract_transf_matrix[1][2] 0.000000
_atom_sites.fract_transf_matrix[1][3] 0.000000
_atom_sites.fract_transf_matrix[2][1] 0.000000
_atom_sites.fract_transf_matrix[2][2] 1.000000
_atom_sites.fract_transf_matrix[2][3] 0.000000
_atom_sites.fract_transf_matrix[3][1] 0.000000
_atom_sites.fract_transf_matrix[3][2] 0.000000
_atom_sites.fract_transf_matrix[3][3] 1.000000
_atom_sites.fract_transf_vector[1] 0.00000
_atom_sites.fract_transf_vector[2] 0.00000
_atom_sites.fract_transf_vector[3] 0.00000
#
loop_
_atom_type.symbol
C
N
O
S
#
loop_