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The Journey Newsletter (December 2024)
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Real-world evidence is at the center of OHDSI research, and it was a key topic in the community throughout November. One community call was focused on generating it through the OHDSI Evidence Network, while another looked at potential ways to improve the dissemination process. Evidence will be shared in Singapore this month during the 2024 APAC Symposium. We reflect on that and more in the latest edition of the OHDSI newsletter. #JoinTheJourney
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Podcast: Evidence Dissemination, Semaglutide Network Study, APAC Symposium
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In the latest On The Journey videocast, Patrick Ryan and Craig Sachson discuss a recent community call focused on evidence dissemination within the community, including the new Evidence Translation workgroup. They also discuss the recent Evidence Network study on semaglutide, and they look ahead to the 2024 APAC Symposium. (if video does not appear, please click view this email in your browser)
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Where Have We Been?
• Five posters/demos were honored as Best Community Contribution Award winners following the 2024 Global Symposium. You can see the posters here, and presentations about each are available at the bottom of this newsletter.
Observational Data Standards and Management: Gap Analysis of Static Automated Perimetry Concept Representation in OMOP CDM (Shahin Hallaj)
Methodological Research: Towards automated phenotype definition extraction using large language models (Ramya Tekumalla)
Open-Source Analytics Development: Bridging the Language Gap: Generative Models for Efficient Medical Concept Discovery (Alvaro Alvarez)
Clinical Applications: Health Trends Across Communities in Minnesota: a Statewide Dashboard Leveraging the OMOP CDM to Monitor the Prevalence of Health Conditions (Samuel Patnoe)
Community: Improving Team Science Through “Thons” Reflections on the April Olympians Community Event (Clair Blacketer)
• Jennifer Clark Nelson, Director of Biostatistics & Senior Investigator at Kaiser Permanente Washington Health Research Institute, presented a talk on Statistical methods for improving post-licensure vaccine safety surveillance during a Nov. 20 edition of the CBER BEST Seminar Series.
• The latest edition of “Our Journey: Where the OHDSI Community Has Been, and Where We Are Going” was distributed at the Global Symposium, and the online version is available on the OHDSI website.
Where Are We Now?
• The 2024 OHDSI Asia-Pacific (APAC) Symposium will be held December 4-8 in Singapore. Regional co-chairs Mengling ‘Mornin’ Feng and Ngial Kee Yuan will lead this event, which has a theme of “When OHDSI Meets with AI.”
• The CDM Survey subgroup invites colleagues who have or are going to design, develop, and/or implement research surveys and use them with the OMOP CDM to share information about those efforts by completing this survey by Dec. 31, 2024. If you are filling this out for more than one survey, please list all surveys you describe in section 1. You may also fill out one assessment per survey. Your completion of this 10-15 minute survey will provide information to the CDM workgroup about OMOP utilization among survey research teams. The CDM Survey subgroup is a collaborative effort, led by a team at the National Cancer Institute, to develop standardized approaches and best practices for helping research teams better integrate survey data elements into the OMOP common data model.
Where Are We Going?
• The #OHDSISocialShowcase will feature posters, software demos and lightning talks from the 2024 Global Symposiums this month. Please make sure you are following OHDSI’s LinkedIn, Twitter/X and Instagram feeds to receive daily updates on the research presented by our community.
• There were more than 25 workgroup activities held during the final day of the global symposium, and rooms were packed with excited collaborators ready to help move these missions forward. If you would like to join any of our groups as they plan 2025 objectives and key results, please fill out our workgroup interest form.
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Symposium Tutorials, Including Intro to OHDSI & Four Specialized Sessions, Are Now Available
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Leaders within the OHDSI community led a day of tutorials to open the 2024 Global Symposium, and each of those sessions are now available on the event homepage.
The first session was "An Introduction to the Journey from Data to Evidence Using OHDSI" tutorial, which focuses on the tools, practices, and open-science approach to evidence generation that the OHDSI community has developed and evolved over the past decade.
There were four specialized tutorials held during the first afternoon of the event that provided more in-depth education about different aspects of OHDSI research:
- Conducting 'Off-The-Shelf' Characterization Studies Using DARWIN EU® Tools and the OMOP CDM
- Developing and Evaluating Your Extract, Transform, Load (ETL) Process to the OMOP Common Data Model
- So, You Think You Want To Run an OHDSI Network Study?
- Using the OHDSI Standardized Vocabularies for Research
You can find all the tutorials, as well as the main conference talks and collaborator showcase submissions, via the event page below.
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Cindy X. Cai, M.D., is the Jonathan and Marcia Javitt Rising Professor of Ophthalmology at Johns Hopkins University and a retina specialist seeing patients at the Wilmer Eye Institute’s locations in the Baltimore, Maryland area. Her primary focuses are in medical and surgical retina treatments, including: diabetic retinopathy, diabetic macular edema, and age-related macular degeneration.
Cindy graduated summa cum laude with a major in biology at Columbia University and received her M.D. from the Columbia University College of Physicians and Surgeons in New York. She led one of the 2023 SOS Challenge studies, which highlighted every step of an OHDSI network study, including design, implementations, execution, and dissemination.
A co-lead of the Eyecare and Vision Research Workgroup, Cindy is currently leading another OHDSI network study focused on Semaglutide and Nonarteritic Anterior Ischemic Optic Neuropathy. The 2024 Titan Award for Clinical Applications honoree, she discusses her career journey, her experience running her first community network study, opportunities in vision research using real-world data, and plenty more in the latest collaborator spotlight.
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2024 Asia-Pacific Symposium Focuses On "When OHDSI Meets With AI"
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The 2024 OHDSI Asia-Pacific (APAC) Symposium will be held December 4-8 in Singapore. Regional co-chairs Mengling 'Mornin' Feng and Ngial Kee Yuan will lead this event, which has a theme of "When OHDSI Meets with AI."
The five-day event begins with a tutorial on Dec. 4 at the National University of Singapore (NUS), and it will include sessions on OMOP, the ETL process, and OHDSI analytics tools. The main conference will be held Dec. 5-6 at the Marina Bay Sands; the full agenda for both days is available on the event homepage below. There will be a two-day datathon on Dec. 7-8 at NUS.
All details about the event, including a link to register, is available on the APAC 2024 homepage.
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Tekumalla R, Banda JM. Towards automated phenotype definition extraction using large language models. Genomics Inform. 2024 Oct 31;22(1):21. doi: 10.1186/s44342-024-00023-2. PMID: 39482749; PMCID: PMC11529293.
Ferrandiz-Espadin R, Rabasa G, Gasman S, McGinley B, Stovall R, Jafarzadeh SR, Liew JW, Dubreuil M. Disparities in time to diagnosis of Radiographic Axial Spondyloarthritis. J Rheumatol. 2024 Nov 4:jrheum.2024-0574. doi: 10.3899/jrheum.2024-0574. Epub ahead of print. PMID: 39486857.
Tong J, Li L, Reps JM, Lorman V, Jing N, Edmondson M, Lou X, Jhaveri R, Kelleher KJ, Pajor NM, Forrest CB, Bian J, Chu H, Chen Y. Advancing Interpretable Regression Analysis for Binary Data: A Novel Distributed Algorithm Approach. Stat Med. 2024 Nov 3. doi: 10.1002/sim.10250. Epub ahead of print. PMID: 39489875.
Pyun JM, Lee I, Lee K, Kim MH, Park C, Yang HJ. Effect of Choline Alfoscerate on the Progression From Mild Cognitive Impairment to Dementia: Distributed Network Analysis of a Multicenter Korean Database Using a Common Data Model. Dement Neurocogn Disord. 2024 Oct;23(4):202-211. doi: 10.12779/dnd.2024.23.4.202. Epub 2024 Oct 7. PMID: 39512703; PMCID: PMC11538851.
Dernie F, Corby G, Robinson A, Bezer J, Mercade-Besora N, Griffier R, Verdy G, Leis A, Ramirez-Anguita JM, Mayer MA, Brash JT, Seager S, Parry R, Jodicke A, Duarte-Salles T, Rijnbeek PR, Verhamme K, Pacurariu A, Morales D, Pinheiro L, Prieto-Alhambra D, Prats-Uribe A. Standardised and Reproducible Phenotyping Using Distributed Analytics and Tools in the Data Analysis and Real World Interrogation Network (DARWIN EU). Pharmacoepidemiol Drug Saf. 2024 Nov;33(11):e70042. doi: 10.1002/pds.70042. PMID: 39532529.
Eisman AS, Chen ES, Wu WC, Crowley KM, Aluthge DP, Brown K, Sarkar IN. Learning health system linchpins: information exchange and a common data model. J Am Med Inform Assoc. 2024 Nov 13:ocae277. doi: 10.1093/jamia/ocae277. Epub ahead of print. PMID: 39538369.
Kimura E, Kawakami Y, Inoue S, Okajima A. Mapping Drug Terms via Integration of a Retrieval-Augmented Generation Algorithm with a Large Language Model. Healthc Inform Res. 2024 Oct;30(4):355-363. doi: 10.4258/hir.2024.30.4.355. Epub 2024 Oct 31. PMID: 39551922; PMCID: PMC11570653.
Xie J, López-Güell K, Dedman D, Duarte-Salles T, Kolde R, López-Blasco R, Martínez Á, Mercier G, Abellan A, Arinze JT, Cuccu Z, Delmestri A, Delseny D, Khalid S, Kim C, Kim JW, Kostka K, Loste C, Mateu L, Mayer MA, Meléndez-Cardiel J, Mercadé-Besora N, Mosseveld M, Nishimura A, Nordeng HME, Oyinlola JO, Pérez-Crespo L, Pineda-Moncusí M, Ramírez-Anguita JM, Trinh NTH, Uusküla A, Valdivieso B, Burkard T, Burn E, Català M, Prieto-Alhambra D, Paredes R, Jödicke AM. Incidence of post-acute COVID-19 symptoms across healthcare settings in seven countries: an international retrospective cohort study using routinely-collected data. EClinicalMedicine. 2024 Oct 30;77:102903. doi: 10.1016/j.eclinm.2024.102903. PMID: 39552716; PMCID: PMC11564986.
Quaye A, DiPalazzo J, Kostka K, Richard JM, Beers-Mulroy B, Peck M, Krulee R, Zhang Y. Identifying factors associated with persistent opioid use after total joint arthroplasty: A retrospective review. Pain Med. 2024 Nov 20:pnae120. doi: 10.1093/pm/pnae120. Epub ahead of print. PMID: 39565915.
Datseris G, Zelko JS. Physiological signal analysis and open science using the Julia language and associated software. Front Netw Physiol. 2024 Nov 6;4:1478280. doi: 10.3389/fnetp.2024.1478280. PMID: 39569020; PMCID: PMC11577965.
Kurtz M, Winter A, Löbe M. Suitability of the OMOP Common Data Model for Mapping Datasets of Medical Research Studies Using the Example of a Multicenter Registry. Stud Health Technol Inform. 2024 Nov 22;321:170-174. doi: 10.3233/SHTI241086. PMID: 39575802.
Lee H, Kim S, Moon HW, Lee HY, Kim K, Jung SY, Yoo S. Hospital Length of Stay Prediction for Planned Admissions Using Observational Medical Outcomes Partnership Common Data Model: Retrospective Study. J Med Internet Res. 2024 Nov 22;26:e59260. doi: 10.2196/59260. PMID: 39576284.
Hong SW, Kang JH. Antinuclear Positivity and Malignant Transformation Potential of Oral Potentially Malignant Disorder. Oral Dis. 2024 Nov 25. doi: 10.1111/odi.15208. Epub ahead of print. PMID: 39587821.
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Nov. 5: Meet the Titans
Full Presentation (Janetzki, Cai, Zhuk, Zhang, Adulyannukosol, Blacketer, Camprubi, Katzman, Lavallee)
Nov. 12: Next Steps in Evidence Dissemination
Full Presentation (Ryan, Schuemie, Pratt)
Nov. 19 Evidence Network in Action: The Semiglutide Study
Full Presentation (Cai, Zhang, Nagy, Sena, Westlund, Martin)
Nov. 26: OHDSI 2024 Best Community Contribution Honorees
Gap Analysis of Static Automated Perimetry Concept Representation in OMOP CDM (Hallaj)
Towards automated phenotype definition extraction using large language models (Tekumalla)
Bridging the Language Gap: Generative Models for Efficient Medical Concept Discovery (Alvarez)
Health Trends Across Communities in Minnesota: a Statewide Dashboard Leveraging the OMOP CDM to Monitor the Prevalence of Health Conditions (Patnoe)
Improving Team Science Through “Thons” Reflections on the April Olympians Community Event (Blacketer)
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