Abstract
We report in this communication a simple, facile surface modification strategy to transfer hydrophobic manganese oxide nanoparticles (MONPs) into water by using polyaspartic acid (PASP). We systematically investigated the effect of the size of PASP-MONPs on MRI of normal liver and found that the particles with a core size of 10 nm exhibited greater enhancement than those with larger core sizes.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, N.I.H., Intramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Coated Materials, Biocompatible* / chemistry
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Coated Materials, Biocompatible* / pharmacology
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Contrast Media* / chemistry
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Contrast Media* / pharmacology
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Liver / diagnostic imaging*
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Magnesium Oxide* / chemistry
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Magnesium Oxide* / pharmacology
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Magnetic Resonance Imaging / methods*
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Mice
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Nanoparticles / chemistry*
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Particle Size
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Peptides* / chemistry
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Peptides* / pharmacology
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Radiography
Substances
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Coated Materials, Biocompatible
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Contrast Media
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Peptides
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polyaspartate
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Magnesium Oxide